P22893

PR
Gene name
Zfp36
Protein name
mRNA decay activator protein ZFP36
Names
Growth factor-inducible nuclear protein NUP475, TPA-induced sequence 11, Tristetraprolin, Zinc finger protein 36, Zfp-36
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:22695
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

46-115 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for P22893

Entry ID Method Resolution Chain Position Source
1M9O NMR - A 91-163 PDB
AF-P22893-F1 Predicted AlphaFoldDB

16 variants for P22893

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388895461 31 W>L No EVA
rs3388895462 42 V>L No EVA
rs3388890507 83 P>H No EVA
rs3388867486 102 R>W No EVA
rs3388893600 108 G>W No EVA
rs3388892969 124 E>G No EVA
rs3388852688 127 Q>K No EVA
rs3388893522 160 P>L No EVA
rs3388898828 187 R>S No EVA
rs3388867458 188 S>G No EVA
rs3388890448 209 S>N No EVA
rs3388898850 236 D>Y No EVA
rs222007186 239 Q>P No EVA
rs3396929267 279 S>C No EVA
rs256701557 299 P>L No EVA
rs3388894016 304 A>V No EVA

No associated diseases with P22893

2 regional properties for P22893

Type Name Position InterPro Accession
domain Zinc finger, CCCH-type 95 - 123 IPR000571-1
domain Zinc finger, CCCH-type 133 - 161 IPR000571-2

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm
  • Cytoplasmic granule
  • Cytoplasm, P-body
  • Shuttles between nucleus and cytoplasm in a CRM1-dependent manner (PubMed:11796723, PubMed:11886850)
  • Localized predominantly in the cytoplasm in a p38 MAPK- and YWHAB-dependent manner (PubMed:11886850, PubMed:16508015)
  • Colocalizes with SH3KBP1 and MAP3K4 in the cytoplasm (By similarity)
  • Component of cytoplasmic stress granules (SGs) (PubMed:15967811)
  • Localizes to cytoplasmic stress granules upon energy starvation (PubMed:15014438)
  • Localizes in processing bodies (PBs) (By similarity)
  • Excluded from stress granules in a phosphorylation MAPKAPK2-dependent manner (PubMed:15014438)
  • Shuttles in and out of both cytoplasmic P-body and SGs (PubMed:15967811)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic stress granule A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
P-body A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.
ribonucleoprotein complex A macromolecular complex that contains both RNA and protein molecules.
RISC-loading complex A trimeric protein complex required for the formation of a mature RNA-induced silencing complex (RISC). In humans the complex is composed of the endonuclease Dicer (DICER1), TRBP (TARBP2) and the Argonaute protein Ago2 (EIF2C2/AGO2). Within the complex, Dicer and TRBP are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto Ago2. Ago2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from Dicer and TRBP. This complex has endoribonuclease activity.

12 GO annotations of molecular function

Name Definition
14-3-3 protein binding Binding to a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxy-terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins.
C-C chemokine binding Binding to a C-C chemokine; C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
enzyme binding Binding to an enzyme, a protein with catalytic activity.
heat shock protein binding Binding to a heat shock protein, a protein synthesized or activated in response to heat shock.
metal ion binding Binding to a metal ion.
mRNA 3'-UTR AU-rich region binding Binding to a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule or in pre-mRNA intron. The ARE-binding element consensus is UUAUUUAUU. ARE-binding proteins control the stability and/or translation of mRNAs.
mRNA 3'-UTR binding Binding to a 3' untranslated region of an mRNA molecule.
mRNA binding Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
protein kinase binding Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
protein-containing complex binding Binding to a macromolecular complex.
RNA polymerase binding Binding to an RNA polymerase molecule or complex.

43 GO annotations of biological process

Name Definition
3'-UTR-mediated mRNA destabilization An mRNA destabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA.
3'-UTR-mediated mRNA stabilization An mRNA stabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA.
cellular response to epidermal growth factor stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus.
cellular response to fibroblast growth factor stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an fibroblast growth factor stimulus.
cellular response to glucocorticoid stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
cellular response to granulocyte macrophage colony-stimulating factor stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte macrophage colony-stimulating factor stimulus.
cellular response to lipopolysaccharide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
cellular response to tumor necrosis factor Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
hematopoietic stem cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
MAPK cascade An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
miRNA-mediated gene silencing by inhibition of translation An RNA interference pathway in which microRNAs (miRNAs) block the translation of target mRNAs into proteins. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA will typically mediate repression of translation if the miRNA imperfectly base-pairs with the 3' untranslated regions of target mRNAs.
mRNA catabolic process The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.
mRNA transport The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
myeloid cell differentiation The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages.
negative regulation of erythrocyte differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of erythrocyte differentiation.
negative regulation of hematopoietic stem cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell differentiation.
negative regulation of inflammatory response Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.
negative regulation of interleukin-2 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production.
negative regulation of myeloid cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid cell differentiation.
negative regulation of polynucleotide adenylyltransferase activity Any process that stops, prevents or reduces the frequency, rate or extent of polynucleotide adenylyltransferase activity.
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
negative regulation of viral transcription Any process that stops, prevents, or reduces the frequency, rate or extent of viral transcription.
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability.
nuclear-transcribed mRNA catabolic process, deadenylation-independent decay A pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of steps that is independent of deadenylation, but requires decapping followed by transcript decay, and that can regulate mRNA stability.
nuclear-transcribed mRNA poly(A) tail shortening Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length.
p38MAPK cascade An intracellular protein kinase cascade containing at least a p38 MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA Any process that activates or increases the frequency, rate or extent of deadenylation-independent decapping of nuclear-transcribed mRNA.
positive regulation of fat cell differentiation Any process that activates or increases the frequency, rate or extent of adipocyte differentiation.
positive regulation of intracellular mRNA localization Any process that activates or increases the frequency, rate or extent of intracellular mRNA localization.
positive regulation of miRNA-mediated gene silencing A process that activates or increases the frequency, rate or extent of gene silencing by a microRNA (miRNA).
positive regulation of mRNA catabolic process Any process that increases the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Any process that activates or increases the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay.
positive regulation of nuclear-transcribed mRNA poly(A) tail shortening Any process that increases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length.
regulation of keratinocyte apoptotic process Any process that modulates the frequency, rate or extent of keratinocyte apoptotic process.
regulation of keratinocyte differentiation Any process that modulates the frequency, rate or extent of keratinocyte differentiation.
regulation of keratinocyte proliferation Any process that modulates the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population.
regulation of mRNA stability Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
regulation of tumor necrosis factor production Any process that modulates the frequency, rate or extent of tumor necrosis factor production.
response to starvation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment.
response to wounding Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
RNA destabilization Any process that decreases the stability of an RNA molecule, making it more vulnerable to degradative processes.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q84UQ3 Os08g0159800 Zinc finger CCCH domain-containing protein 56 Oryza sativa subsp japonica (Rice) PR
10 20 30 40 50 60
MDLSAIYESL QSMSHDLSSD HGGTESLGGL WNINSDSIPS GVTSRLTGRS TSLVEGRSCG
70 80 90 100 110 120
WVPPPPGFAP LAPRPGPELS PSPTSPTATP TTSSRYKTEL CRTYSESGRC RYGAKCQFAH
130 140 150 160 170 180
GLGELRQANR HPKYKTELCH KFYLQGRCPY GSRCHFIHNP TEDLALPGQP HVLRQSISFS
190 200 210 220 230 240
GLPSGRRSSP PPPGFSGPSL SSCSFSPSSS PPPPGDLPLS PSAFSAAPGT PVTRRDPNQA
250 260 270 280 290 300
CCPSCRRSTT PSTIWGPLGG LARSPSAHSL GSDPDDYASS GSSLGGSDSP VFEAGVFGPP
310
QTPAPPRRLP IFNRISVSE