P17426

PR
Gene name
Ap2a1 (Adtaa, Clapa1)
Protein name
AP-2 complex subunit alpha-1
Names
100 kDa coated vesicle protein A, Adaptor protein complex AP-2 subunit alpha-1, Adaptor-related protein complex 2 subunit alpha-1, Alpha-adaptin A, Alpha1-adaptin, Clathrin assembly protein complex 2 alpha-A large chain, Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:11771
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

593-695 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P17426

Entry ID Method Resolution Chain Position Source
AF-P17426-F1 Predicted AlphaFoldDB

33 variants for P17426

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388904887 127 F>S No EVA
rs3388908737 184 P>H No EVA
rs3388893795 195 L>M No EVA
rs3388908667 213 C>Y No EVA
rs3388908643 218 N>K No EVA
rs3388908677 255 P>A No EVA
rs3388907679 298 K>M No EVA
rs3397853069 299 K>E No EVA
rs3397871557 313 T>I No EVA
rs3411747147 358 S>N No EVA
rs3397707544 371 D>N No EVA
rs3388903323 401 N>S No EVA
rs3388911874 421 R>Q No EVA
rs3388904885 431 L>M No EVA
rs3388903308 434 K>R No EVA
rs3388911892 476 Q>K No EVA
rs3388908994 525 L>M No EVA
rs3388904966 597 T>K No EVA
rs3388904958 610 S>L No EVA
rs3388887006 617 K>E No EVA
rs3397707576 645 E>A No EVA
rs3411112006 645 E>D No EVA
rs3397841549 649 S>G No EVA
rs1132301862 676 V>I No EVA
rs3388889477 681 L>P No EVA
rs3388910376 697 P>S No EVA
rs3388908682 775 R>H No EVA
rs3388880534 806 A>T No EVA
rs3388866973 861 I>F No EVA
rs3388909796 920 D>E No EVA
rs3388910432 943 L>H No EVA
rs3388904893 947 P>T No EVA
rs3388898631 948 N>T No EVA

No associated diseases with P17426

No regional properties for P17426

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P17426

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane
  • Membrane, coated pit ; Peripheral membrane protein ; Cytoplasmic side
  • AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

10 GO annotations of cellular component

Name Definition
AP-2 adaptor complex A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle, and the cargo receptors during receptor/clathrin mediated endocytosis. Vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC).
apical plasma membrane The region of the plasma membrane located at the apical end of the cell.
basolateral plasma membrane The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
clathrin-coated vesicle A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes.
cytoplasmic side of plasma membrane The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
filopodium tip The end of a filopodium distal to the body of the cell.
membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules.
postsynapse The part of a synapse that is part of the post-synaptic cell.
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
secretory granule A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules.

6 GO annotations of molecular function

Name Definition
cargo adaptor activity Binding directly to the structural scaffolding elements of a vesicle coat (such as clathrin or COPII), and bridging the membrane, cargo receptor, and membrane deformation machinery.
clathrin adaptor activity Bringing together a cargo protein with clathrin, responsible for the formation of endocytic vesicles.
low-density lipoprotein particle receptor binding Binding to a low-density lipoprotein receptor.
protein C-terminus binding Binding to a protein C-terminus, the end of a peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
protein kinase binding Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
protein-containing complex binding Binding to a macromolecular complex.

8 GO annotations of biological process

Name Definition
clathrin-dependent endocytosis An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles.
intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
negative regulation of hyaluronan biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of hyaluronan biosynthetic process.
positive regulation of neuron projection development Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
positive regulation of receptor-mediated endocytosis Any process that activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport.
postsynaptic neurotransmitter receptor internalization A receptor-mediated endocytosis process that results in the internalization of a neurotransmitter receptor from the postsynaptic membrane endocytic zone into an endocytic vesicle.
receptor-mediated endocytosis An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.
vesicle-mediated transport A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O95782 AP2A1 AP-2 complex subunit alpha-1 Homo sapiens (Human) PR
P22892 Ap1g1 AP-1 complex subunit gamma-1 Mus musculus (Mouse) PR
10 20 30 40 50 60
MPAVSKGDGM RGLAVFISDI RNCKSKEAEI KRINKELANI RSKFKGDKAL DGYSKKKYVC
70 80 90 100 110 120
KLLFIFLLGH DIDFGHMEAV NLLSSNKYTE KQIGYLFISV LVNSNSELIR LINNAIKNDL
130 140 150 160 170 180
ASRNPTFMCL ALHCIANVGS REMGEAFAAD IPRILVAGDS MDSVKQSAAL CLLRLYKASP
190 200 210 220 230 240
DLVPMGEWTA RVVHLLNDQH MGVVTAAVSL ITCLCKKNPD DFKTCISLAV SRLSRIVSSA
250 260 270 280 290 300
STDLQDYTYY FVPAPWLSVK LLRLLQCYPP PEDAAVKGRL VECLETVLNK AQEPPKSKKV
310 320 330 340 350 360
QHSNAKNAIL FETISLIIHY DSEPNLLVRA CNQLGQFLQH RETNLRYLAL ESMCTLASSE
370 380 390 400 410 420
FSHEAVKTHI DTVINALKTE RDVSVRQRAA DLLYAMCDRS NAKQIVSEML RYLETADYAI
430 440 450 460 470 480
REEIVLKVAI LAEKYAVDYS WYVDTILNLI RIAGDYVSEE VWYRVLQIVT NRDDVQGYAA
490 500 510 520 530 540
KTVFEALQAP ACHENMVKVG GYILGEFGNL IAGDPRSSPP VQFSLLHSKF HLCSVATRAL
550 560 570 580 590 600
LLSTYIKFIN LFPETKATIQ GVLRAGSQLR NADVELQQRA VEYLTLSSVA STDVLATVLE
610 620 630 640 650 660
EMPPFPERES SILAKLKRKK GPGAASALDD SRRDTSSNDI NGGVEPTPST VSTPSPSADL
670 680 690 700 710 720
LGLRAAPPPA APPAPVGGNL LVDVFSDGPT AQPSLGPTPE EAFLSELEPP APESPMALLA
730 740 750 760 770 780
DPAPAADPGP EDIGPPIPEA DELLNKFVCK NSGVLFENQL LQIGVKSEFR QNLGRMYLFY
790 800 810 820 830 840
GNKTSVQFQN FLPTVVHPGD LQTQLAVQTK RVAAQVDGGA QVQQVLNIEC LRDFLTPPLL
850 860 870 880 890 900
SVRFRYGGTA QSLTLKLPVT INKFFQPTEM AAQDFFQRWK QLSLPLQEAQ KIFKANHPMD
910 920 930 940 950 960
AEVTKAKLLG FGSALLDNVD PNPENFVGAG IIQTKALQVG CLLRLEPNAQ AQMYRLTLRT
970
SKEPVSRHLC ELLAQQF