P17214
PR
Gene name |
EST1 (YLR233C, L8083.15) |
Protein name |
Telomere elongation protein EST1 |
Names |
Ever shorter telomeres protein 1 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YLR233C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P17214
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P17214-F1 | Predicted | AlphaFoldDB |
32 variants for P17214
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s12-609490 | 13 | L>I | No | SGRP | |
| s12-609485 | 14 | F>L | No | SGRP | |
| s12-609403 | 42 | C>S | No | SGRP | |
| s12-609382 | 49 | R>C | No | SGRP | |
| s12-609369 | 53 | R>K | No | SGRP | |
| s12-609310 | 73 | R>C | No | SGRP | |
| s12-609301 | 76 | D>Y | No | SGRP | |
| s12-609232 | 99 | E>K | No | SGRP | |
| s12-609167 | 120 | F>L | No | SGRP | |
| s12-609080 | 149 | N>K | No | SGRP | |
| s12-609054 | 158 | A>V | No | SGRP | |
| s12-608887 | 214 | K>E | No | SGRP | |
| s12-608879 | 216 | K>N | No | SGRP | |
| s12-608785 | 248 | I>V | No | SGRP | |
| s12-608697 | 277 | N>T | No | SGRP | |
| s12-608668 | 287 | D>N | No | SGRP | |
| s12-608529 | 333 | S>L | No | SGRP | |
| s12-608474 | 351 | M>I | No | SGRP | |
| s12-608157 | 457 | R>K | No | SGRP | |
| s12-608095 | 478 | S>P | No | SGRP | |
| s12-607923 | 535 | V>A | No | SGRP | |
| s12-607924 | 535 | V>M | No | SGRP | |
| s12-607914 | 538 | P>Q | No | SGRP | |
| s12-607816 | 571 | Y>H | No | SGRP | |
| s12-607811 | 572 | K>N | No | SGRP | |
| s12-607792 | 579 | N>D | No | SGRP | |
| s12-607781 | 582 | I>M | No | SGRP | |
| s12-607711 | 606 | S>T | No | SGRP | |
| s12-607657 | 624 | K>E | No | SGRP | |
| s12-607533 | 665 | R>K | No | SGRP | |
| s12-607459 | 690 | I>V | No | SGRP | |
| s12-607453 | 692 | V>I | No | SGRP |
No associated diseases with P17214
4 regional properties for P17214
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | RNA recognition motif domain | 51 - 129 | IPR000504-1 |
| domain | RNA recognition motif domain | 137 - 217 | IPR000504-2 |
| domain | RNA recognition motif domain | 302 - 380 | IPR000504-3 |
| domain | HuD, RNA recognition motif 3 | 299 - 384 | IPR034918 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromosome, telomeric region | The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres). |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| telomerase holoenzyme complex | Telomerase is a ribonucleoprotein enzyme complex, with a minimal catalytic core composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition. In vivo, the holoenzyme complex often contains additional subunits. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| single-stranded DNA binding | Binding to single-stranded DNA. |
| telomeric DNA binding | Binding to a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| G-quadruplex DNA formation | A DNA metabolic process that results in the formation of G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad or G-quartet. The stacking of several layers of G-quartets forms G-quadruplexes, in which one or more DNA single strands are assembled in parallel and/or antiparallel, with interactions that can be either intra- or intermolecular in nature. |
| regulation of telomere maintenance via telomerase | Any process that modulates the frequency, rate or extent of the addition of telomeric repeats by telomerase. |
| telomere maintenance | Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences. |
| telomere maintenance via telomerase | The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDNEEVNEEC | MRLFFKNARA | HLDKHLTSRL | TCDENAYITF | RCFLDGIHRK | STRFLEELLL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KQENMYHNNN | YERINDSVIP | LVLKLLWLQI | HEPTLQWFEH | WFHDIMRLSN | RRKFRVFRIF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QKKMIQFFKI | THRYYYDIIE | HLCAKYDMNS | VISNALFAKL | NLMQYTDGLS | THEKIILNTS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NPLTFSIVIS | LQRCVINLGS | THFYKTLLNK | PSNKPKSVEG | FEKSIRYLNI | ASLYLPAVGD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TYFQRAKIYL | ITGKFSLYFF | ELVRGALVRI | PSKCALNNLK | DFILTPDFPE | RRRLMKKLAI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LVSKDLKGEK | SFFEGQIVLQ | FLSIVEHTLV | PQSWNASRAS | NCWLLKEHLQ | MAALKYHSGN |
| 370 | 380 | 390 | 400 | 410 | 420 |
| INVILENLAA | TMGSFDLMFT | TRKSKEQKNK | LKYADLSERQ | VFFLDLSFDF | IANIIDVVIK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PSWQKNMEDF | RYLAIIRLLM | CWIKSYRSIL | QYTHRHRKFC | TSFALLLNDL | INSPLNCSGN |
| 490 | 500 | 510 | 520 | 530 | 540 |
| IYSHRPKRSY | LFREDIIFRE | FSCINFALTD | FNDDYVYDSP | DMINNIIGCP | TLTKVLSPKE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ECVLRIRSII | FSGMKFLEKN | DTGVIWNASK | YKFDLISPNI | KIKRQIALSE | ISSKINVKTQ |
| 610 | 620 | 630 | 640 | 650 | 660 |
| QERVVSSRKV | EAKRDEQQRK | RAGKIAVTEL | EKQFANVRRT | KKLSPLPEKD | GVSSELVKHA |
| 670 | 680 | 690 | |||
| ASRGRKTITG | PLSSDFLSYP | DEAIDADEDI | TVQVPDTPT |