A9QM73
PR
Gene name |
SMG7 |
Protein name |
Nonsense-mediated mRNA decay factor SMG7 |
Names |
Protein SMG7, SMG7 homolog |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G19400 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A9QM73
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A9QM73-F1 | Predicted | AlphaFoldDB |
77 variants for A9QM73
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_5_6540899_G_T | 34 | K>N | No | 1000Genomes | |
| ENSVATH00632176 | 77 | K>R | No | 1000Genomes | |
| tmp_5_6541053_A_G | 86 | I>V | No | 1000Genomes | |
| tmp_5_6541080_T_A | 95 | S>T | No | 1000Genomes | |
| tmp_5_6541231_C_T | 145 | S>F | No | 1000Genomes | |
| tmp_5_6541364_G_A | 189 | M>I | No | 1000Genomes | |
| ENSVATH00632178 | 296 | L>S | No | 1000Genomes | |
| tmp_5_6541964_T_C | 320 | F>S | No | 1000Genomes | |
| ENSVATH00632179 | 346 | S>F | No | 1000Genomes | |
| tmp_5_6542173_C_T | 364 | T>I | No | 1000Genomes | |
| tmp_5_6542244_C_G | 388 | H>D | No | 1000Genomes | |
| tmp_5_6542281_C_T | 400 | A>V | No | 1000Genomes | |
| ENSVATH06995769 | 409 | A>V | No | 1000Genomes | |
| ENSVATH06995771 | 440 | P>S | No | 1000Genomes | |
| ENSVATH14095173 | 441 | G>A | No | 1000Genomes | |
| tmp_5_6542440_C_T | 453 | P>L | No | 1000Genomes | |
| ENSVATH06995772 | 456 | A>P | No | 1000Genomes | |
| ENSVATH06995772 | 456 | A>T | No | 1000Genomes | |
| ENSVATH06995775 | 509 | R>I | No | 1000Genomes | |
| tmp_5_6542719_C_T | 546 | T>I | No | 1000Genomes | |
| ENSVATH10861115 | 554 | A>V | No | 1000Genomes | |
| tmp_5_6542766_G_T | 562 | A>S | No | 1000Genomes | |
| tmp_5_6542833_A_C | 584 | K>T | No | 1000Genomes | |
| ENSVATH03080960 | 603 | P>L | No | 1000Genomes | |
| ENSVATH03080960 | 603 | P>R | No | 1000Genomes | |
| ENSVATH10861118 | 607 | C>Y | No | 1000Genomes | |
| ENSVATH10861119 | 608 | N>D | No | 1000Genomes | |
| ENSVATH10861120 | 619 | H>Q | No | 1000Genomes | |
| ENSVATH14095174 | 620 | N>S | No | 1000Genomes | |
| tmp_5_6542949_A_C | 623 | I>L | No | 1000Genomes | |
| ENSVATH06995776 | 630 | I>N | No | 1000Genomes | |
| ENSVATH06995777 | 654 | E>Q | No | 1000Genomes | |
| ENSVATH10861121 | 666 | F>C | No | 1000Genomes | |
| tmp_5_6543120_G_C | 680 | A>P | No | 1000Genomes | |
| ENSVATH06995778 | 689 | H>Q | No | 1000Genomes | |
| ENSVATH03080961 | 691 | N>I | No | 1000Genomes | |
| ENSVATH00632182 | 700 | A>V | No | 1000Genomes | |
| tmp_5_6543193_T_C | 704 | V>A | No | 1000Genomes | |
| tmp_5_6543199_C_T | 706 | A>V | No | 1000Genomes | |
| ENSVATH10861122 | 709 | G>V | No | 1000Genomes | |
| tmp_5_6543214_A_T | 711 | N>I | No | 1000Genomes | |
| ENSVATH10861123 | 721 | Q>L | No | 1000Genomes | |
| tmp_5_6543334_C_T | 751 | S>L | No | 1000Genomes | |
| tmp_5_6543333_T_A | 751 | S>T | No | 1000Genomes | |
| tmp_5_6543359_G_A | 759 | M>I | No | 1000Genomes | |
| tmp_5_6543358_T_C | 759 | M>T | No | 1000Genomes | |
| tmp_5_6543367_T_C | 762 | V>A | No | 1000Genomes | |
| tmp_5_6543418_G_T | 779 | R>L | No | 1000Genomes | |
| ENSVATH06995781 | 790 | P>S | No | 1000Genomes | |
| ENSVATH10861135 | 810 | P>L | No | 1000Genomes | |
| tmp_5_6543513_G_T | 811 | A>S | No | 1000Genomes | |
| ENSVATH00632183 | 816 | T>N | No | 1000Genomes | |
| tmp_5_6543553_G_T | 824 | W>L | No | 1000Genomes | |
| tmp_5_6543640_A_T | 853 | Q>L | No | 1000Genomes | |
| ENSVATH00632185 | 861 | Y>N | No | 1000Genomes | |
| tmp_5_6543684_G_A | 868 | V>I | No | 1000Genomes | |
| tmp_5_6543697_A_T | 872 | Y>F | No | 1000Genomes | |
| tmp_5_6543730_C_G | 883 | S>C | No | 1000Genomes | |
| tmp_5_6543741_A_G | 887 | T>A | No | 1000Genomes | |
| ENSVATH10861138 | 894 | P>H | No | 1000Genomes | |
| tmp_5_6543768_A_G | 896 | I>V | No | 1000Genomes | |
| tmp_5_6543786_T_A | 902 | S>T | No | 1000Genomes | |
| ENSVATH03080963 | 917 | K>R | No | 1000Genomes | |
| ENSVATH06995784 | 920 | P>T | No | 1000Genomes | |
| tmp_5_6543916_C_T | 945 | P>L | No | 1000Genomes | |
| tmp_5_6543928_C_T | 949 | S>L | No | 1000Genomes | |
| ENSVATH06995785 | 959 | V>I | No | 1000Genomes | |
| ENSVATH06995786 | 970 | A>G | No | 1000Genomes | |
| ENSVATH14095228 | 971 | Q>H | No | 1000Genomes | |
| ENSVATH00632188 | 974 | R>L | No | 1000Genomes | |
| tmp_5_6544005_G_A | 975 | G>S | No | 1000Genomes | |
| tmp_5_6544063_G_A | 994 | G>D | No | 1000Genomes | |
| ENSVATH06995788 | 1007 | P>L | No | 1000Genomes | |
| ENSVATH06995789 | 1012 | Q>E | No | 1000Genomes | |
| ENSVATH06995790 | 1029 | Q>H | No | 1000Genomes | |
| ENSVATH10861140 | 1050 | Q>L | No | 1000Genomes | |
| ENSVATH10861140 | 1050 | Q>P | No | 1000Genomes |
No associated diseases with A9QM73
1 regional properties for A9QM73
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | B0AT3, solute-binding domain | 16 - 591 | IPR042701 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| P-body | A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing. |
| telomerase holoenzyme complex | Telomerase is a ribonucleoprotein enzyme complex, with a minimal catalytic core composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition. In vivo, the holoenzyme complex often contains additional subunits. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| telomerase RNA binding | Binding to the telomerase RNA template. |
| telomeric DNA binding | Binding to a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| defense response | Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. |
| meiotic cell cycle | Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions. |
| meiotic spindle assembly | The aggregation, arrangement and bonding together of a set of components to form the spindle that contributes to the process of meiosis. |
| negative regulation of cell death | Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death. |
| nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins. |
| programmed cell death | A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell. |
| regulation of defense response | Any process that modulates the frequency, rate or extent of a defense response. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MMTLQMDKTT | ASSSWERAKS | IYDEIAELAN | KRQKAGNPPD | PNLLQLLREK | YEAIILESHT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FSEQHNIEIP | LWQLHYKRIE | YFRLHINRVL | ASSTSTAAQN | VKGPSKAEQI | AQLKLQFRTF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LSEATGFYHD | MILKIRSKYG | LPLGSFSEDQ | QSQNLSDKDG | KELAEVQKAL | KSCHRCLIYL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GDLARYKGMY | AEGDSRSRQY | ASASSYYLQA | ASLWPASGNP | HHQLAIVASY | SRDEFVTTYR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YFRSLAVEYP | FPTARDNLIV | AFDKNRQSYE | KLFVPSKDSS | KRLTGKGRGK | GADISLKDAT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LVAGPEKDKV | TIANEMLKAF | SIRFVHLNGI | LFTRTSLETF | FDVLASTSSS | LREVISLGSA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KELTLGIDTS | DSALFIVRVV | TMLIFSVHNS | KKETEGQSYA | EIVQRVEPAR | NSLTASFELL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GLVIEKCVQL | GDPSSSYFLP | GVLVFVEWLA | CCPDIALGSD | PDDRQTAVRN | SFWNQFVVFF |
| 490 | 500 | 510 | 520 | 530 | 540 |
| NQVLSLGPTF | IDDVEDETCF | SNMSLYDERE | TENRLALWED | YELRGFLPLL | PAQTILNFSR |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KHSFGTEGPK | EKKARIKRIF | AAGKALTSVI | KVDQNHVYFD | SKKKKFLVGV | KPADDFLDSH |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SSPPKACNAL | QDNQVMIDHN | SPIMQLDQQI | YMGEEDDDDE | VIVFKPLVTE | KRKEASDQIY |
| 670 | 680 | 690 | 700 | 710 | 720 |
| VPSGGFRKSD | QVTTMGDFKA | LSGSDVAFHE | NQILQARGNA | SIQVPASVGA | NLLGPLQPST |
| 730 | 740 | 750 | 760 | 770 | 780 |
| QSQAMHMQQV | QTQVQVPASV | GANLLGLLLT | STQSQAMHMQ | QVQTQAVNPQ | PAQSLAASRL |
| 790 | 800 | 810 | 820 | 830 | 840 |
| QPIQSQVAQP | LPSRVVHFQQ | TQAQVSHVSP | AHSQSTSFGG | GSKWSPEEAA | SLASSLSGFA |
| 850 | 860 | 870 | 880 | 890 | 900 |
| QLGNGHVMRN | EMQGNHGVSY | YPAHSLPVHQ | SYNGNGMGGM | PYSQSRTPEA | VFPPKIDPVL |
| 910 | 920 | 930 | 940 | 950 | 960 |
| SSGVVADGLG | VQSSLAKKNP | ISRAFRHLGP | PPGFNSVPAK | LQKEPAPGSE | LSGNNHLPVD |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| DYSWLDGYQA | QSSRGVGLNS | SLNYATSGKP | EHLGSTGNGL | NGPANFPFPG | KQVPTSQVQA |
| 1030 | 1040 | 1050 | |||
| DFPYFQNPQK | DNFVDKNHQS | TQLPEQYQGQ | STWSSRHFV |