P16330

PR
Gene name
Cnp
Protein name
2',3'-cyclic-nucleotide 3'-phosphodiesterase
Names
CNP, CNPase
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:12799
EC number
3.1.4.37: Phosphoric diester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-64 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

34 structures for P16330

Entry ID Method Resolution Chain Position Source
2XMI X-ray 174 A A 179-398 PDB
2Y1P X-ray 182 A A 179-398 PDB
2Y3X X-ray 210 A A/B/E 179-398 PDB
2YDB X-ray 215 A A 179-398 PDB
2YDC X-ray 205 A A 179-398 PDB
2YDD X-ray 240 A A 179-398 PDB
2YOZ X-ray 210 A A 179-398 PDB
2YP0 X-ray 230 A A 179-398 PDB
2YPC X-ray 189 A A 179-398 PDB
2YPE X-ray 190 A A 179-398 PDB
2YPH X-ray 210 A A 179-398 PDB
2YQ9 X-ray 190 A A 179-398 PDB
3ZBR X-ray 230 A A/B 179-398 PDB
3ZBS X-ray 245 A A 179-398 PDB
3ZBZ X-ray 210 A A 179-398 PDB
4WBI X-ray 200 A A 179-398 PDB
4WBL X-ray 250 A A 179-398 PDB
4WC9 X-ray 200 A A 179-398 PDB
4WCA X-ray 185 A A 179-398 PDB
4WCB X-ray 157 A A 179-398 PDB
4WCC X-ray 270 A A 179-398 PDB
4WDA X-ray 185 A A 179-398 PDB
4WDB X-ray 160 A A 179-398 PDB
4WDD X-ray 210 A A 179-398 PDB
4WDE X-ray 240 A A/B 179-398 PDB
4WDF X-ray 200 A A 179-398 PDB
4WDG X-ray 205 A A 179-398 PDB
4WDH X-ray 190 A A 179-398 PDB
4WEX X-ray 210 A A 179-398 PDB
4WFR X-ray 200 A A 179-398 PDB
5AE0 X-ray 104 A A 179-398 PDB
7QZK X-ray 166 A A 179-398 PDB
7QZS X-ray 180 A A 179-398 PDB
AF-P16330-F1 Predicted AlphaFoldDB

23 variants for P16330

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389205713 7 R>H No EVA
rs3389197984 10 H>L No EVA
rs3389197039 37 L>H No EVA
rs3389205569 39 D>N No EVA
rs3389197098 44 A>D No EVA
rs3389205677 80 M>L No EVA
rs3389212543 107 L>P No EVA
rs3389136721 118 L>I No EVA
rs3389217826 120 L>H No EVA
rs3389136746 130 L>V No EVA
rs3389197970 143 Q>L No EVA
rs3389176474 154 R>Q No EVA
rs3389197895 166 W>R No EVA
rs3389205722 166 W>S No EVA
rs3389203316 184 F>I No EVA
rs3389205752 196 K>E No EVA
rs3389210544 203 K>N No EVA
rs3389212601 218 F>I No EVA
rs3389203334 219 K>M No EVA
rs3389205540 251 C>F No EVA
rs3389138179 293 K>N No EVA
rs225429568 303 D>G No EVA
rs3389210527 407 G>S No EVA

No associated diseases with P16330

1 regional properties for P16330

Type Name Position InterPro Accession
domain Cyclic nucleotide phosphodiesterase, catalytic domain 185 - 419 IPR047325

Functions

Description
EC Number 3.1.4.37 Phosphoric diester hydrolases
Subcellular Localization
  • Membrane ; Lipid-anchor
  • Melanosome
  • Firmly bound to membrane structures of brain white matter
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

15 GO annotations of cellular component

Name Definition
cell projection A prolongation or process extending from a cell, e.g. a flagellum or axon.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
melanosome A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
microvillus Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells.
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
myelin sheath An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.
myelin sheath abaxonal region The region of the myelin sheath furthest from the axon.
myelin sheath adaxonal region The region of the myelin sheath nearest to the axon.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
pseudopodium A temporary protrusion or retractile process of a cell, associated with flowing movements of the protoplasm, and serving for locomotion and feeding.

3 GO annotations of molecular function

Name Definition
2',3'-cyclic-nucleotide 3'-phosphodiesterase activity Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 2'-phosphate.
cyclic nucleotide binding Binding to a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue.
RNA binding Binding to an RNA molecule or a portion thereof.

10 GO annotations of biological process

Name Definition
adult locomotory behavior Locomotory behavior in a fully developed and mature organism.
aging A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
axonogenesis De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells.
cyclic nucleotide catabolic process The chemical reactions and pathways resulting in the breakdown of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue.
forebrain development The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).
microtubule cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
oligodendrocyte differentiation The process in which a relatively unspecialized cell acquires the specialized features of an oligodendrocyte. An oligodendrocyte is a type of glial cell involved in myelinating the axons of neurons in the central nervous system.
regulation of mitochondrial membrane permeability Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane.
response to lipopolysaccharide Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
response to toxic substance Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P06623 CNP 2',3'-cyclic-nucleotide 3'-phosphodiesterase Bos taurus (Bovine) PR
Q92802 N4BP2L2 NEDD4-binding protein 2-like 2 Homo sapiens (Human) PR
P09543 CNP 2',3'-cyclic-nucleotide 3'-phosphodiesterase Homo sapiens (Human) PR
P13233 Cnp 2',3'-cyclic-nucleotide 3'-phosphodiesterase Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MNTSFTRKSH TFLPKLFFRK MSSSGAKEKP ELQFPFLQDE DTVATLHECK TLFILRGLPG
70 80 90 100 110 120
SGKSTLARLI LEKYHDGTKM VSADAYKIIP GSRADFSEAY KRLDEDLAGY CRRDIRVLVL
130 140 150 160 170 180
DDTNHERERL DQLFEMADQY QYQVVLVEPK TAWRLDCAQL KEKNQWQLSA DDLKKLKPGL
190 200 210 220 230 240
EKDFLPLYFG WFLTKKSSET LRKAGQVFLE ELGNHKAFKK ELRHFISGDE PKEKLELVSY
250 260 270 280 290 300
FGKRPPGVLH CTTKFCDYGK AAGAEEYAQQ EVVKRSYGKA FKLSISALFV TPKTAGAQVV
310 320 330 340 350 360
LTDQELQLWP SDLDKPSASE GLPPGSRAHV TLGCAADVQP VQTGLDLLDI LQQVKGGSQG
370 380 390 400 410
EAVGELPRGK LYSLGKGRWM LSLTKKMEVK AIFTGYYGKG KPVPIHGSRK GGAMQICTII