P06623
PR
Gene name |
CNP |
Protein name |
2',3'-cyclic-nucleotide 3'-phosphodiesterase |
Names |
CNP, CNPase, Elastase 2',3'-cyclic-nucleotide 3'-phosphodiesterase |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:280752 |
EC number |
3.1.4.37: Phosphoric diester hydrolases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P06623
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P06623-F1 | Predicted | AlphaFoldDB |
129 variants for P06623
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs436584272 | 2 | S>A | No | EVA | |
| rs456769566 | 3 | S>A | No | EVA | |
| rs476664095 | 4 | S>A | No | EVA | |
| rs438926253 | 16 | F>Y | No | EVA | |
| rs458852924 | 17 | L>R | No | EVA | |
| rs876163906 | 21 | E>G | No | EVA | |
| rs472648952 | 21 | E>Q | No | EVA | |
| rs876394141 | 22 | T>P | No | EVA | |
| rs876454362 | 23 | V>G | No | EVA | |
| rs441224095 | 25 | T>P | No | EVA | |
| rs480365492 | 28 | E>D | No | EVA | |
| rs448985271 | 36 | R>G | No | EVA | |
| rs462591773 | 40 | G>R | No | EVA | |
| rs444945721 | 42 | G>A | No | EVA | |
| rs482498595 | 42 | G>R | No | EVA | |
| rs465061358 | 46 | L>Q | No | EVA | |
| rs465061358 | 46 | L>R | No | EVA | |
| rs447244693 | 48 | R>W | No | EVA | |
| rs436698912 | 50 | I>F | No | EVA | |
| rs456683429 | 51 | V>M | No | EVA | |
| rs476820140 | 54 | Y>H | No | EVA | |
| rs432440129 | 54 | Y>S | No | EVA | |
| rs441191988 | 58 | T>A | No | EVA | |
| rs441191988 | 58 | T>P | No | EVA | |
| rs461345810 | 58 | T>S | No | EVA | |
| rs473862230 | 60 | M>T | No | EVA | |
| rs442700888 | 61 | V>A | No | EVA | |
| rs462551154 | 63 | A>P | No | EVA | |
| rs482611683 | 64 | D>G | No | EVA | |
| rs458645949 | 65 | S>C | No | EVA | |
| rs478789788 | 66 | Y>H | No | EVA | |
| rs447196087 | 68 | I>L | No | EVA | |
| rs481686404 | 69 | T>I | No | EVA | |
| rs467371743 | 69 | T>P | No | EVA | |
| rs470515810 | 76 | F>Y | No | EVA | |
| rs466272966 | 84 | D>A | No | EVA | |
| rs452667563 | 84 | D>Y | No | EVA | |
| rs454728615 | 85 | E>K | No | EVA | |
| rs474828075 | 87 | L>R | No | EVA | |
| rs443625435 | 94 | D>H | No | EVA | |
| rs438575377 | 100 | L>R | No | EVA | |
| rs458689563 | 108 | E>K | No | EVA | |
| rs440916423 | 111 | E>G | No | EVA | |
| rs478707941 | 111 | E>Q | No | EVA | |
| rs460907599 | 112 | Q>E | No | EVA | |
| rs480997894 | 113 | L>V | No | EVA | |
| rs449732315 | 115 | E>* | No | EVA | |
| rs477794721 | 116 | L>V | No | EVA | |
| rs466325343 | 117 | A>G | No | EVA | |
| rs446182844 | 117 | A>T | No | EVA | |
| rs468538793 | 118 | D>A | No | EVA | |
| rs468538793 | 118 | D>G | No | EVA | |
| rs454862988 | 118 | D>Y | No | EVA | |
| rs437158025 | 119 | Q>P | No | EVA | |
| rs452256301 | 120 | Y>* | No | EVA | |
| rs476504386 | 120 | Y>D | No | EVA | |
| rs438690474 | 120 | Y>S | No | EVA | |
| rs472394583 | 121 | Q>H | No | EVA | |
| rs441076396 | 122 | Y>D | No | EVA | |
| rs441076396 | 122 | Y>H | No | EVA | |
| rs461021843 | 123 | Q>P | No | EVA | |
| rs461021843 | 123 | Q>R | No | EVA | |
| rs481159647 | 124 | V>G | No | EVA | |
| rs443234563 | 125 | V>A | No | EVA | |
| rs443234563 | 125 | V>G | No | EVA | |
| rs463359377 | 126 | L>V | No | EVA | |
| rs477692756 | 127 | V>G | No | EVA | |
| rs446328163 | 128 | E>A | No | EVA | |
| rs446328163 | 128 | E>G | No | EVA | |
| rs460087569 | 129 | P>A | No | EVA | |
| rs480049490 | 130 | K>Q | No | EVA | |
| rs437272050 | 133 | W>G | No | EVA | |
| rs437272050 | 133 | W>R | No | EVA | |
| rs450754668 | 133 | W>S | No | EVA | |
| rs464548286 | 136 | D>G | No | EVA | |
| rs472560894 | 145 | Q>R | No | EVA | |
| rs434560780 | 146 | W>G | No | EVA | |
| rs454760130 | 147 | Q>* | No | EVA | |
| rs443347083 | 147 | Q>H | No | EVA | |
| rs474658168 | 147 | Q>R | No | EVA | |
| rs463335862 | 149 | S>T | No | EVA | |
| rs459995108 | 158 | P>A | No | EVA | |
| rs479960369 | 161 | E>V | No | EVA | |
| rs448554819 | 167 | L>F | No | EVA | |
| rs471481287 | 168 | Y>* | No | EVA | |
| rs462188559 | 172 | F>L | No | EVA | |
| rs482098385 | 173 | L>R | No | EVA | |
| rs464698970 | 175 | K>N | No | EVA | |
| rs446884664 | 181 | L>V | No | EVA | |
| rs466013946 | 190 | E>D | No | EVA | |
| rs381796648 | 196 | K>R | No | EVA | |
| rs454676061 | 201 | E>G | No | EVA | |
| rs472102371 | 207 | S>F | No | EVA | |
| rs477195657 | 213 | E>A | No | EVA | |
| rs454332554 | 230 | H>Q | No | EVA | |
| rs474248656 | 240 | K>N | No | EVA | |
| rs445335651 | 247 | Y>N | No | EVA | |
| rs442967094 | 248 | A>G | No | EVA | |
| rs462921826 | 249 | Q>H | No | EVA | |
| rs476629043 | 251 | D>G | No | EVA | |
| rs448242108 | 252 | V>A | No | EVA | |
| rs448242108 | 252 | V>G | No | EVA | |
| rs468419059 | 253 | V>M | No | EVA | |
| rs437014798 | 257 | Y>C | No | EVA | |
| rs450543344 | 264 | T>P | No | EVA | |
| rs464272380 | 265 | I>T | No | EVA | |
| rs452800721 | 269 | F>S | No | EVA | |
| rs435875566 | 274 | T>R | No | EVA | |
| rs476031666 | 286 | L>R | No | EVA | |
| rs458240288 | 291 | N>K | No | EVA | |
| rs440392353 | 295 | K>M | No | EVA | |
| rs479679595 | 300 | D>E | No | EVA | |
| rs462048579 | 306 | S>R | No | EVA | |
| rs482066595 | 311 | T>A | No | EVA | |
| rs482066595 | 311 | T>P | No | EVA | |
| rs450640491 | 314 | C>G | No | EVA | |
| rs464052878 | 315 | A>E | No | EVA | |
| rs135658705 | 321 | V>G | No | EVA | |
| rs432851321 | 343 | V>G | No | EVA | |
| rs446376216 | 344 | G>A | No | EVA | |
| rs435187305 | 345 | E>D | No | EVA | |
| rs476150056 | 361 | L>R | No | EVA | |
| rs438176636 | 364 | A>D | No | EVA | |
| rs432588206 | 389 | R>H | No | EVA | |
| rs440563025 | 389 | R>S | No | EVA | |
| rs462048043 | 394 | F>L | No | EVA | |
| rs442842828 | 394 | F>S | No | EVA | |
| rs450621237 | 398 | T>P | No | EVA | |
| rs457803450 | 399 | I>N | No | EVA |
No associated diseases with P06623
1 regional properties for P06623
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Cyclic nucleotide phosphodiesterase, catalytic domain | 165 - 399 | IPR047325 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.4.37 | Phosphoric diester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| extracellular space | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
| melanosome | A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells. |
| myelin sheath | An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity | Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 2'-phosphate. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| adult locomotory behavior | Locomotory behavior in a fully developed and mature organism. |
| axonogenesis | De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells. |
| cyclic nucleotide catabolic process | The chemical reactions and pathways resulting in the breakdown of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue. |
| oligodendrocyte differentiation | The process in which a relatively unspecialized cell acquires the specialized features of an oligodendrocyte. An oligodendrocyte is a type of glial cell involved in myelinating the axons of neurons in the central nervous system. |
| response to toxic substance | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q92802 | N4BP2L2 | NEDD4-binding protein 2-like 2 | Homo sapiens (Human) | PR |
| P09543 | CNP | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | Homo sapiens (Human) | PR |
| P16330 | Cnp | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | Mus musculus (Mouse) | PR |
| P13233 | Cnp | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSSGAKDKP | ELQFPFLQDE | ETVATLQECK | TLFILRGLPG | SGKSTLARFI | VDKYRDGTKM |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VSADSYKITP | GARGSFSEEY | KQLDEDLAAC | CRRDFRVLVL | DDTNHERERL | EQLFELADQY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QYQVVLVEPK | TAWRLDCAQL | KEKNQWQLSA | DDLKKLKPGL | EKDFLPLYFG | WFLTKKSSAA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LWKTGQTFLE | ELGNHKAFKK | ELRHFVSGDE | PREKIELVTY | FGKRPPGVLH | CTTKFCDYGK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AAGAEEYAQQ | DVVKKSYCKA | FTLTISALFV | TPKTTGARVE | LSEQQLALWP | NDVDKLSPSD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NLPRGSRAHI | TLGCAGDVEA | VQTGIDLLEI | VRQEKGGSRG | EEVGELSRGK | LYSLGSGRWM |
| 370 | 380 | 390 | |||
| LSLAKKMEVR | AIFTGYYGKG | KAVPIRSGRK | GGSFQSCTII |