P15723

PR
Gene name
dgt
Protein name
Deoxyguanosinetriphosphate triphosphohydrolase
Names
dGTP triphosphohydrolase, dGTPase
Species
Escherichia coli (strain K12)
KEGG Pathway
eco:b0160
EC number
3.1.5.1: Triphosphoric monoester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-53 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

11 structures for P15723

Entry ID Method Resolution Chain Position Source
4X9E X-ray 310 A A/B/C/D/E/F 1-505 PDB
4XDS X-ray 335 A A/B/C/D/E/F 1-505 PDB
6OI7 X-ray 290 A A/B/C/D/E/F 1-505 PDB
6OIV X-ray 306 A A/B/C/D/E/F 1-505 PDB
6OIW X-ray 335 A A/B/C/D/E/F 1-505 PDB
6OIX X-ray 315 A A/B/C/D/E/F 1-505 PDB
6OIY X-ray 329 A A/B/C/D/E/F 1-505 PDB
7U65 EM 280 A A/B/C/D/E/F 1-505 PDB
7U66 EM 310 A A/B/C/D/E/F 1-505 PDB
7U67 EM 250 A A/B/C/D/E/F 1-505 PDB
AF-P15723-F1 Predicted AlphaFoldDB

No variants for P15723

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P15723

No associated diseases with P15723

3 regional properties for P15723

Type Name Position InterPro Accession
domain HD/PDEase domain 62 - 282 IPR003607
domain HD domain 66 - 273 IPR006674
domain Phosphohydrolase-associated domain 379 - 499 IPR026875

Functions

Description
EC Number 3.1.5.1 Triphosphoric monoester hydrolases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

7 GO annotations of molecular function

Name Definition
cobalt ion binding Binding to a cobalt ion (Co).
dGTPase activity Catalysis of the reaction: dGTP + H(2)O = 2'-deoxyguanosine + 2 H(+) + triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
identical protein binding Binding to an identical protein or proteins.
magnesium ion binding Binding to a magnesium (Mg) ion.
manganese ion binding Binding to a manganese ion (Mn).
single-stranded DNA binding Binding to single-stranded DNA.

2 GO annotations of biological process

Name Definition
dGTP catabolic process The chemical reactions and pathways resulting in the breakdown of dGTP, guanosine triphosphate.
nucleobase-containing small molecule interconversion The chemical reactions and pathways by which a nucleobase, nucleoside or nucleotide small molecule is synthesized from another nucleobase, nucleoside or nucleotide small molecule.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5ZJL9 SAMHD1 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Gallus gallus (Chicken) PR
Q9Y3Z3 SAMHD1 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Homo sapiens (Human) PR
Q60710 Samhd1 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Mus musculus (Mouse) PR
10 20 30 40 50 60
MAQIDFRKKI NWHRRYRSPQ GVKTEHEILR IFESDRGRII NSPAIRRLQQ KTQVFPLERN
70 80 90 100 110 120
AAVRTRLTHS MEVQQVGRYI AKEILSRLKE LKLLEAYGLD ELTGPFESIV EMSCLMHDIG
130 140 150 160 170 180
NPPFGHFGEA AINDWFRQRL HPEDAESQPL TDDRCSVAAL RLRDGEEPLN ELRRKIRQDL
190 200 210 220 230 240
CHFEGNAQGI RLVHTLMRMN LTWAQVGGIL KYTRPAWWRG ETPETHHYLM KKPGYYLSEE
250 260 270 280 290 300
AYIARLRKEL NLALYSRFPL TWIMEAADDI SYCVADLEDA VEKRIFTVEQ LYHHLHEAWG
310 320 330 340 350 360
QHEKGSLFSL VVENAWEKSR SNSLSRSTED QFFMYLRVNT LNKLVPYAAQ RFIDNLPAIF
370 380 390 400 410 420
AGTFNHALLE DASECSDLLK LYKNVAVKHV FSHPDVERLE LQGYRVISGL LEIYRPLLSL
430 440 450 460 470 480
SLSDFTELVE KERVKRFPIE SRLFHKLSTR HRLAYVEAVS KLPSDSPEFP LWEYYYRCRL
490 500
LQDYISGMTD LYAWDEYRRL MAVEQ