AiPD: Autoinhibited Protein Database

P14625

Gene name	HSP90B1
Protein name	Endoplasmin
Names	94 kDa glucose-regulated protein, GRP-94, Heat shock protein 90 kDa beta member 1, Tumor rejection antigen 1, gp96 homolog
Species	Homo sapiens (Human)
KEGG Pathway	hsa:7184
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

4-82 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

4-82 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

3 structures for P14625

Entry ID	Method	Resolution	Chain	Position	Source
4NH9	X-ray	277 A	A	69-337	PDB
7ULL	X-ray	231 A	A/B	69-337	PDB
AF-P14625-F1	Predicted				AlphaFoldDB

504 variants for P14625

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs200731731 CA6753280	2	R>K		No	ClinGen 1000Genomes ExAC gnomAD
rs367697851 CA6753282	2	R>S		No	ClinGen ESP ExAC gnomAD
CA6753284 rs149528402	6	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs746813568 CA6753285	8	G>D		No	ClinGen ExAC gnomAD
rs560306771 CA386316198	9	L>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs560306771 CA6753286	9	L>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs866639231 CA242548158	10	C>*		No	ClinGen Ensembl
rs1201598114 CA386316227	10	C>S		No	ClinGen TOPMed
CA386316273 rs761866435	12	V>F		No	ClinGen ExAC TOPMed gnomAD
CA6753288 rs761866435	12	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1414682155 CA386316520	19	V>L		No	ClinGen gnomAD
rs747864450 CA6753305	21	A>T		No	ClinGen ExAC TOPMed gnomAD
CA6753306 rs769897961	21	A>V		No	ClinGen ExAC gnomAD
rs773231799 CA6753307	22	D>E		No	ClinGen ExAC gnomAD
rs775421580 CA6753310	23	D>G		No	ClinGen ExAC gnomAD
rs759717800 CA6753308	23	D>N		No	ClinGen ExAC gnomAD
rs759717800 CA6753309	23	D>Y		No	ClinGen ExAC gnomAD
rs761026206 CA6753311	25	V>A		No	ClinGen ExAC TOPMed gnomAD
CA6753312 rs764191996	27	V>M		No	ClinGen ExAC gnomAD
CA6753313 rs777102409	28	D>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	30	T>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1320691429 CA386316670	31	V>I		No	ClinGen gnomAD
rs1593486635 CA386316694	34	D>G		No	ClinGen Ensembl
CA6753316 rs201068970	34	D>N		No	ClinGen ExAC gnomAD
CA242548506 rs201068970	34	D>Y		No	ClinGen ExAC gnomAD
TCGA novel	35	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	36	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1262949989 CA386316712	37	K>R		No	ClinGen gnomAD
CA6753317 rs757919459	38	S>N		No	ClinGen ExAC gnomAD
rs765969582 CA6753318	39	R>K		No	ClinGen ExAC gnomAD
rs1593486657 CA386316734	40	E>G		No	ClinGen Ensembl
CA386316750 rs1593486671	41	G>E		No	ClinGen Ensembl
rs1238298711 CA386316822	46	D>V		No	ClinGen gnomAD
CA386316835 rs1475171241	47	E>Q		No	ClinGen gnomAD
rs1425862457 CA386316854	48	V>A		No	ClinGen gnomAD
CA386316846 rs148706377	48	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA6753319 CA6753320 rs148706377	48	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA386316869 rs1171262903	49	V>G		No	ClinGen gnomAD
rs780682319 CA6753321	49	V>I		No	ClinGen ExAC gnomAD
rs1412568996 CA386316875	50	Q>K		No	ClinGen gnomAD
rs1387949086 CA386317936	52	E>K		No	ClinGen gnomAD
rs576057501 CA6753355	59	D>G		No	ClinGen 1000Genomes ExAC gnomAD
CA386318089 rs1482744806	60	G>E		No	ClinGen TOPMed
CA6753358 rs377222712	63	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1277061078 CA386318132	63	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA386318154 rs1245513133	65	Q>H		No	ClinGen gnomAD
rs1273085634 CA386318169	66	I>M		No	ClinGen TOPMed
CA386318174 rs1263799075	67	R>K		No	ClinGen gnomAD
rs763817003 CA6753359	69	L>F		No	ClinGen ExAC gnomAD
rs762196975	71	E>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA6753363 rs372981677	73	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA6753362 rs372981677	73	S>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs865844557 CA386318315	77	A>D		No	ClinGen gnomAD
CA386318316 rs865844557	77	A>G		No	ClinGen gnomAD
CA242548678 rs865844557	77	A>V		No	ClinGen gnomAD
rs781314286 CA6753366	81	E>K		No	ClinGen ExAC TOPMed gnomAD
rs201119782 CA242548683	83	N>H		No	ClinGen 1000Genomes
TCGA novel	84	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs571691885 CA6753367	84	R>K		No	ClinGen 1000Genomes ExAC gnomAD
CA6753368 rs770047423	85	M>I		No	ClinGen ExAC TOPMed gnomAD
CA6753369 rs777918443	88	L>F		No	ClinGen ExAC TOPMed gnomAD
rs771132893 CA6753371	89	I>V		No	ClinGen ExAC gnomAD
CA6753372 rs774934129	90	I>V		No	ClinGen ExAC gnomAD
CA6753373 rs760017425	91	N>S		No	ClinGen ExAC gnomAD
CA386318640 rs1310873260	93	L>F		No	ClinGen gnomAD
CA6753375 rs775190500	94	Y>H		No	ClinGen ExAC gnomAD
TCGA novel	100	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1253969163 CA386318945	101	L>P		No	ClinGen gnomAD
CA6753393 rs776100889	104	L>M		No	ClinGen ExAC TOPMed gnomAD
rs1362809151 CA386319051	105	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs746522202 CA6753394	105	I>V		No	ClinGen ExAC gnomAD
TCGA novel	107	N>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs768227408 CA6753395	109	S>F		No	ClinGen ExAC gnomAD
CA242548827 rs1022987363	112	L>S		No	ClinGen Ensembl
CA386319175 rs1418208869	113	D>G		No	ClinGen gnomAD
CA6753396 rs776271094	114	K>E		No	ClinGen ExAC gnomAD
rs761441712 CA6753397	115	I>R		No	ClinGen ExAC gnomAD
rs368880453 CA242548839	126	L>F		No	ClinGen ESP TOPMed
CA6753400 rs772925950	128	G>R		No	ClinGen ExAC
CA6753402 rs766330879	130	E>*		No	ClinGen ExAC gnomAD
rs751430839 CA6753403	131	E>K		No	ClinGen ExAC
rs1158190787 CA386319452	134	V>I		No	ClinGen gnomAD
rs747580924 CA6753414	138	C>Y		No	ClinGen ExAC gnomAD
rs769283715 CA6753415	139	D>G		No	ClinGen ExAC gnomAD
CA386319714 rs1421696359	142	K>E		No	ClinGen TOPMed gnomAD
CA242549073 rs202077306	147	V>A		No	ClinGen 1000Genomes
TCGA novel	154	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6753417 rs747669144	160	V>L		No	ClinGen ExAC gnomAD
CA6753418 rs769352271	165	T>N		No	ClinGen ExAC gnomAD
CA6753420 rs762737984	166	I>M		No	ClinGen ExAC gnomAD
rs1308186605 CA386320188	166	I>V		No	ClinGen gnomAD
CA386320290 rs774118680	172	S>R		No	ClinGen ExAC gnomAD
TCGA novel	173	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1320570659 CA386320296	173	E>Q		No	ClinGen gnomAD
CA386320351 rs1218681745	176	N>K		No	ClinGen gnomAD
rs1285595205 CA386320347	176	N>S		No	ClinGen TOPMed gnomAD
rs544086568 CA242549077	178	M>I		No	ClinGen 1000Genomes
CA386320372 rs1267789106	178	M>V		No	ClinGen gnomAD
rs1489055240 CA386320397	179	T>I		No	ClinGen gnomAD
CA386320398 rs1490573630	180	E>K		No	ClinGen gnomAD
rs939432213 CA242549079	181	A>V		No	ClinGen TOPMed gnomAD
CA242549080 rs988217942	182	Q>K		No	ClinGen TOPMed gnomAD
rs1441852694 CA386320450	183	E>A		No	ClinGen TOPMed gnomAD
CA386320508 rs1179464633	187	S>T		No	ClinGen gnomAD
rs913069286 CA242549085	192	I>V		No	ClinGen TOPMed
rs201423886 CA242549088	199	F>L		No	ClinGen 1000Genomes
COSM1358304 CA6753429 rs368251601	202	A>T	Variant assessed as Somatic; 9.24e-05 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	204	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs200565749 CA242549094	204	L>P		No	ClinGen 1000Genomes
rs1309564146 CA386320846	205	V>I		No	ClinGen gnomAD
CA386320875 rs1377941211	207	D>N		No	ClinGen gnomAD
CA386320902 rs1177184303	208	K>E		No	ClinGen TOPMed
rs1018491944 CA242549096	209	V>L		No	ClinGen Ensembl
rs1226121528 CA386320955	210	I>N		No	ClinGen gnomAD
CA6753430 rs780636706	211	V>I		No	ClinGen ExAC gnomAD
CA386321008 rs1322917989	215	H>Y		No	ClinGen gnomAD
CA6753431 rs371098260	217	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA6753433 rs781687324	218	D>N		No	ClinGen ExAC TOPMed gnomAD
CA6753436 rs777303569	221	H>Q		No	ClinGen ExAC TOPMed gnomAD
CA242549118 rs1027315286	221	H>Y		No	ClinGen Ensembl
TCGA novel	223	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs543216677 CA242549123	226	D>A		No	ClinGen 1000Genomes
rs567564451 CA6753437	228	N>S		No	ClinGen ExAC TOPMed gnomAD
CA6753438 rs770564119	229	E>A		No	ClinGen ExAC gnomAD
CA6753439 rs770564119	229	E>V		No	ClinGen ExAC gnomAD
CA242549140 rs950510474	230	F>Y		No	ClinGen Ensembl
rs1348464856 CA386321263	232	V>I		No	ClinGen TOPMed
CA242549146 rs199621152	233	I>T		No	ClinGen 1000Genomes TOPMed gnomAD
CA6753441 rs771936228	234	A>V		No	ClinGen ExAC gnomAD
rs775431470 CA6753442	236	P>S		No	ClinGen ExAC gnomAD
CA386321303 rs1358232704	238	G>E		No	ClinGen gnomAD
TCGA novel	239	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386321321 rs372511163	241	L>V		No	ClinGen gnomAD
CA6753445 rs750530495	243	R>Q		No	ClinGen ExAC gnomAD
CA386321332 rs1355509772	243	R>W		No	ClinGen gnomAD
rs971274341 CA242549163	245	T>M		No	ClinGen gnomAD
CA386321351 rs1278344637	246	T>K		No	ClinGen gnomAD
CA6753448 rs751992055	248	T>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA386321896 rs1193775773	250	V>I		No	ClinGen gnomAD
rs751759985 CA6753465	252	K>N		No	ClinGen ExAC TOPMed gnomAD
rs1329706753 CA386321980	254	E>A		No	ClinGen TOPMed
CA6753466 rs759828460	254	E>K		No	ClinGen ExAC TOPMed gnomAD
CA386321999 rs1566166115	255	A>S		No	ClinGen Ensembl
CA6753467 rs767982403	255	A>V		No	ClinGen ExAC gnomAD
rs201596968 CA6753468	256	S>F		No	ClinGen 1000Genomes ExAC gnomAD
CA386322030 rs1357381212	257	D>N		No	ClinGen TOPMed gnomAD
TCGA novel	257	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1361861386 CA386322078	258	Y>C		No	ClinGen gnomAD
CA6753470 rs764484359	259	L>R		No	ClinGen ExAC gnomAD
CA386322153 rs1323504068	262	D>G		No	ClinGen gnomAD
rs946752566 CA386322170	263	T>I		No	ClinGen TOPMed gnomAD
rs946752566 CA242550046	263	T>K		No	ClinGen TOPMed gnomAD
rs145871780 CA6753471	264	I>M		No	ClinGen ESP ExAC TOPMed
rs935214769 CA242550050	264	I>V		No	ClinGen TOPMed gnomAD
CA6753472 rs375719261	268	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	270	K>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs778550399 CA6753473	270	K>R		No	ClinGen ExAC gnomAD
CA386322353 rs1311612957	273	Q>L		No	ClinGen gnomAD
rs747605736 COSM691526 CA242550089	274	F>L	lung [Cosmic]	No	ClinGen cosmic curated Ensembl
rs779943844 CA242550095	275	I>L		No	ClinGen ExAC TOPMed gnomAD
CA6753476 rs779943844	275	I>V		No	ClinGen ExAC TOPMed gnomAD
CA6753477 rs746760626	280	Y>S		No	ClinGen ExAC TOPMed gnomAD
CA6753479 rs776666589	281	V>I		No	ClinGen ExAC gnomAD
CA6753480 rs749380659	282	W>*		No	ClinGen ExAC gnomAD
CA242550354 rs967955765	286	T>I		No	ClinGen TOPMed
rs1186299039 CA386322798	288	T>A		No	ClinGen gnomAD
rs1366197850 CA386322843	290	E>A		No	ClinGen gnomAD
CA386322875 rs956521013	291	E>D		No	ClinGen TOPMed
rs1474084119 CA386322886	292	P>H		No	ClinGen gnomAD
CA386322910 rs1464422980	293	M>I		No	ClinGen gnomAD
rs144242572 CA6753493	293	M>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA386322950 rs754659333	296	E>K		No	ClinGen ExAC TOPMed gnomAD
rs754659333 CA6753496	296	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs781283473 CA6753497	297	E>A		No	ClinGen ExAC TOPMed gnomAD
rs1275208080 CA386322970	298	A>T		No	ClinGen TOPMed
rs1235232144 CA386322991	300	K>E		No	ClinGen TOPMed
rs368915159 CA6753498	300	K>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA386322997 rs1293862440	301	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA386323020 rs769849088	302	E>*		No	ClinGen ExAC gnomAD
CA386323024 rs922226216	302	E>G		No	ClinGen TOPMed gnomAD
CA6753500 rs769849088	302	E>K		No	ClinGen ExAC gnomAD
CA242550375 rs922226216	302	E>V		No	ClinGen TOPMed gnomAD
CA6753502 rs745913051	303	K>E		No	ClinGen ExAC TOPMed gnomAD
rs1361931233 CA386323056	305	E>K		No	ClinGen TOPMed
rs1445926074 CA386323085	307	D>N		No	ClinGen TOPMed gnomAD
CA6753504 rs200904772	313	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6753505 rs200904772	313	E>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs540321497 CA242550390	315	E>K		No	ClinGen 1000Genomes ExAC gnomAD
rs540321497 CA6753508	315	E>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs1445475737 CA386323258	316	E>G		No	ClinGen TOPMed gnomAD
TCGA novel	318	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1263111731 CA386323305	319	K>E		No	ClinGen gnomAD
CA242550393 rs953501914	319	K>T		No	ClinGen Ensembl
CA6753509 rs116891695	321	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	322	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA242550404 rs941504253	322	K>Q		No	ClinGen TOPMed gnomAD
rs762350787 CA386323432	325	K>N		No	ClinGen ExAC gnomAD
rs762534225 CA6753536	326	V>I		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	326	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1298850817 CA386323476	327	E>G		No	ClinGen TOPMed gnomAD
rs1372804988 CA386323491	329	T>S		No	ClinGen gnomAD
CA386323513 rs1444317491	332	D>E		No	ClinGen TOPMed
CA6753537 rs765860662	332	D>G		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	334	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs751073447 CA6753538	336	M>T		No	ClinGen ExAC gnomAD
rs759301090 CA6753539	338	D>G		No	ClinGen ExAC gnomAD
CA386323554 rs1350887733	338	D>N		No	ClinGen gnomAD
rs1261827213 CA386323566	339	I>T		No	ClinGen gnomAD
rs1381329965 CA386323581	341	P>L		No	ClinGen TOPMed
CA386323583 rs1177091776	342	I>V		No	ClinGen gnomAD
rs879150773 CA242550866	343	W>S		No	ClinGen Ensembl
CA6753540 rs767254008	344	Q>L		No	ClinGen ExAC gnomAD
CA6753541 rs752562529	346	P>L		No	ClinGen ExAC gnomAD
rs1178235071 CA386323650	351	E>D		No	ClinGen gnomAD
rs1454903094	352	E>missing	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	352	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1378649747 CA386323659	352	E>D		No	ClinGen gnomAD
CA386323652 rs1436578733	352	E>K		No	ClinGen TOPMed
rs375594636 CA6753543	353	D>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA386323665 rs1364328926	353	D>E		No	ClinGen TOPMed gnomAD
CA6753542 rs755932488	353	D>N		No	ClinGen ExAC gnomAD
rs753778542 CA6753544	354	E>A		No	ClinGen ExAC gnomAD
TCGA novel	355	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1289815497 CA386323685	356	K>R		No	ClinGen TOPMed
CA386323693 rs1340161527	357	A>G		No	ClinGen gnomAD
CA386323697 rs1396378121	358	F>V		No	ClinGen gnomAD
rs1400817670 CA386323706	359	Y>C		No	ClinGen TOPMed gnomAD
rs1354079125 CA386323704	359	Y>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA386323715 rs1023202465	360	K>I		No	ClinGen gnomAD
rs1023202465 CA242550885	360	K>R		No	ClinGen gnomAD
CA386323741 rs1374110784	364	K>T		No	ClinGen gnomAD
rs1417090011 CA386324282	366	S>G		No	ClinGen gnomAD
CA6753566 rs765175597	367	D>H		No	ClinGen ExAC TOPMed gnomAD
CA386324334 rs1170738721	373	I>V		No	ClinGen gnomAD
CA386324346 rs1385298900	374	H>Q		No	ClinGen TOPMed
rs913376058 CA242551646	374	H>Y		No	ClinGen Ensembl
rs751672357 CA6753567	377	A>G		No	ClinGen ExAC gnomAD
rs781410380 CA6753569	383	F>L		No	ClinGen ExAC gnomAD
CA386324450 rs1399931391	385	S>T		No	ClinGen gnomAD
rs1566167114 CA386324457	386	I>T		No	ClinGen Ensembl
CA6753570 rs748423891	386	I>V		No	ClinGen ExAC gnomAD
CA386324468 rs1364548094	388	F>L		No	ClinGen gnomAD
CA6753571 rs756351032	389	V>I		No	ClinGen ExAC gnomAD
TCGA novel	391	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs749641452 CA6753573	391	T>S		No	ClinGen ExAC gnomAD
TCGA novel	393	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs141254870 CA6753575	395	R>H		No	ClinGen ESP ExAC gnomAD
rs1215782880 CA386324547	397	L>P		No	ClinGen gnomAD
CA386324562 rs1319810115	398	F>L		No	ClinGen TOPMed
CA6753577 rs768456646	399	D>N		No	ClinGen ExAC TOPMed gnomAD
CA6753580 rs374437641	400	E>K		No	ClinGen ESP ExAC gnomAD
CA6753579 rs374437641	400	E>Q		No	ClinGen ESP ExAC gnomAD
TCGA novel	405	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1375491950 CA386324671	407	D>N		No	ClinGen gnomAD
CA6753583 rs377747819	409	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1219171564 CA386324807	412	Y>C		No	ClinGen TOPMed gnomAD
rs1283442344 CA386324819	413	V>M		No	ClinGen gnomAD
CA6753601 rs368374645 COSM1358305	414	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA6753602 rs535356548	414	R>H		No	ClinGen ExAC TOPMed gnomAD
rs769691480 CA6753603	415	R>C		No	ClinGen ExAC gnomAD
CA386324853 rs1443504979	415	R>H		No	ClinGen TOPMed gnomAD
TCGA novel	416	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA242551764 rs564418201	420	D>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6753605 rs762914379	420	D>N		No	ClinGen ExAC TOPMed gnomAD
CA386324981 rs752793223	421	D>H		No	ClinGen ExAC TOPMed gnomAD
rs752793223 CA6753607 COSM1746692	421	D>N	urinary_tract [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs760767560 CA6753608	423	H>Y		No	ClinGen ExAC gnomAD
CA6753610 rs754033382	425	M>T		No	ClinGen ExAC gnomAD
rs1380790566 CA386325172	430	L>V		No	ClinGen gnomAD
CA242551785 rs866621254	431	N>K		No	ClinGen Ensembl
TCGA novel	431	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs779460770 CA6753612	435	G>D		No	ClinGen ExAC gnomAD
TCGA novel	444	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	448	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1423322869 CA386325443	450	T>A		No	ClinGen gnomAD
CA386325533 rs1169896225	457	L>R		No	ClinGen gnomAD
CA6753657 rs755552464	463	K>R		No	ClinGen ExAC TOPMed gnomAD
rs748998107 CA6753659	466	R>C		No	ClinGen ExAC gnomAD
CA242552281 rs938232098	466	R>H		No	ClinGen TOPMed
CA242552284 rs772910819	468	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA6753661 rs778817387	471	M>V		No	ClinGen ExAC TOPMed gnomAD
CA6753662 rs146962447	473	K>T		No	ClinGen ESP ExAC TOPMed
TCGA novel	477	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs772079656 CA6753663	478	D>N		No	ClinGen ExAC gnomAD
rs1468251983 CA386326741	479	K>E		No	ClinGen gnomAD
CA6753665 rs748255104	481	N>S		No	ClinGen ExAC gnomAD
CA6753666 rs770060582	482	D>Y		No	ClinGen ExAC TOPMed gnomAD
rs148024900 CA6753667	483	T>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA242552307 rs749624178	486	K>E		No	ClinGen Ensembl
CA6753668 rs763311324	486	K>R		No	ClinGen ExAC TOPMed gnomAD
rs1434063039 CA386326878	488	F>L		No	ClinGen TOPMed
CA386326908 rs1318897721	490	T>I		No	ClinGen TOPMed
rs1008206764 CA242552313	494	L>F		No	ClinGen Ensembl
CA6753670 rs774797218	497	I>T		No	ClinGen ExAC TOPMed gnomAD
CA6753669 rs766483420	497	I>V		No	ClinGen ExAC gnomAD
rs1323479949 CA386327010	499	D>N		No	ClinGen gnomAD
CA6753671 rs759775976	500	H>P		No	ClinGen ExAC gnomAD
CA386327052 rs1441073648	501	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA386327054 rs1441073648	501	S>W		No	ClinGen gnomAD
CA6753673 COSM934196 rs753142679	503	R>Q	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA242552329 rs1020103855	505	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs964195316 CA242552333	505	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1426851082 CA386327102	506	L>V		No	ClinGen TOPMed
rs374505761 CA6753674	508	K>E		No	ClinGen ESP ExAC gnomAD
CA242552340 rs997420214	508	K>T		No	ClinGen Ensembl
rs1193244585 CA386327154	509	L>F		No	ClinGen TOPMed
TCGA novel	514	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386327235 rs1593491570	518	P>S		No	ClinGen Ensembl
rs548726780 CA242552365	522	T>A		No	ClinGen 1000Genomes TOPMed gnomAD
CA386327318 rs1165775955	523	S>G		No	ClinGen TOPMed gnomAD
rs372371380 CA386327391	526	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs1162506371 CA386327427	528	V>A		No	ClinGen gnomAD
rs983044082 CA242552372	528	V>M		No	ClinGen gnomAD
CA386327509 rs1441179893	532	K>Q		No	ClinGen gnomAD
CA6753679 rs559401907	533	E>D		No	ClinGen 1000Genomes ExAC gnomAD
rs34482425 CA242552384	534	K>N		No	ClinGen Ensembl
rs758073589 CA6753680	534	K>R		No	ClinGen ExAC gnomAD
CA386327597 rs1392559370	537	K>E		No	ClinGen gnomAD
rs1355328251 CA386327607	537	K>N		No	ClinGen gnomAD
rs1308375520 CA386327603	537	K>R		No	ClinGen gnomAD
CA6753681 rs528169940	538	I>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs765949732 CA6753683	541	M>I		No	ClinGen ExAC TOPMed gnomAD
CA6753686 rs771213027	547	K>R		No	ClinGen ExAC gnomAD
CA242552409 rs113326059	548	E>G		No	ClinGen Ensembl
rs1485338698 CA386327825	549	A>T		No	ClinGen gnomAD
CA242552515 rs1041090731	550	E>Q		No	ClinGen Ensembl
rs899875096 CA242552519	553	P>T		No	ClinGen Ensembl
TCGA novel	554	F>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386327880 rs1323473420	557	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs373394058 CA6753700	557	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs996947731 CA386327889	558	L>F		No	ClinGen gnomAD
CA242552523 rs996947731	558	L>I		No	ClinGen gnomAD
CA242552527 rs945371051	560	K>R		No	ClinGen TOPMed
rs754983817 CA6753701	561	K>T		No	ClinGen ExAC TOPMed gnomAD
rs781232223 CA6753702	563	Y>C		No	ClinGen ExAC TOPMed
TCGA novel	565	V>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	567	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6753704 rs770860797	568	L>F		No	ClinGen ExAC gnomAD
rs779039753 CA6753705	569	T>I		No	ClinGen ExAC TOPMed gnomAD
CA386328200 rs1458843568	577	I>F		No	ClinGen TOPMed
rs952874243 CA242552543	579	A>V		No	ClinGen Ensembl
rs772306767 COSM1706178 CA6753707	581	P>L	skin [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA242552546 rs903938928	581	P>S		No	ClinGen TOPMed
CA6753710 COSM1210055 rs769155096	582	E>K	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA242552562 rs763298993	588	F>L		No	ClinGen gnomAD
rs1319483638 CA386328402	591	V>L		No	ClinGen gnomAD
rs762366467 CA6753712	592	A>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA386328437 rs1229397712	593	K>E		No	ClinGen gnomAD
CA6753714 rs749915295	597	K>N		No	ClinGen ExAC gnomAD
CA6753715 rs762557855	598	F>V		No	ClinGen ExAC gnomAD
CA6753717 rs751434474	600	E>D		No	ClinGen ExAC gnomAD
CA242552581 COSM109200 rs143727498	601	S>N	skin [Cosmic]	No	ClinGen cosmic curated gnomAD
CA6753718 rs754755916	603	K>E		No	ClinGen ExAC gnomAD
rs1188817127 CA386328656	606	E>D		No	ClinGen gnomAD
CA6753719 rs141744749	606	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6753720 rs752636677	608	R>C		No	ClinGen ExAC TOPMed gnomAD
rs756076475 CA6753721	608	R>H		No	ClinGen ExAC TOPMed gnomAD
CA386328755 rs1566167719	611	V>A		No	ClinGen Ensembl
CA242552597 rs567003190	611	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen 1000Genomes NCI-TCGA
rs778900551 CA6753722	614	E>D		No	ClinGen ExAC TOPMed gnomAD
CA6753723 rs757332238	616	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs1347335308 CA386328902	620	N>S		No	ClinGen gnomAD
rs1325518885 CA386328933	621	W>L		No	ClinGen gnomAD
CA6753725 rs780183351	622	M>T		No	ClinGen ExAC gnomAD
rs1289744291 CA386328957	622	M>V		No	ClinGen TOPMed
CA386329040 rs1226190814	624	D>A		No	ClinGen TOPMed
CA6753727 rs747385288	627	L>F		No	ClinGen ExAC
CA6753728 rs114330942	629	D>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1387737442 CA386329191	630	K>*		No	ClinGen TOPMed
CA386329397 rs1343337431	633	K>N		No	ClinGen TOPMed
rs1463205499 CA386329411	634	A>T		No	ClinGen gnomAD
CA6753736 rs759251898	634	A>V		No	ClinGen ExAC gnomAD
CA6753738 rs752506564	636	V>A		No	ClinGen ExAC gnomAD
rs377323380 CA6753737	636	V>M		No	ClinGen ESP ExAC gnomAD
TCGA novel	637	S>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1277290411 CA386329479	637	S>F		No	ClinGen TOPMed
CA242552810 rs562235742	639	R>C		No	ClinGen ExAC gnomAD
rs1021322098 CA242552814	639	R>H		No	ClinGen gnomAD
CA6753739 rs562235742	639	R>S		No	ClinGen ExAC gnomAD
rs1332303824 CA386329568	641	T>I		No	ClinGen gnomAD
rs141949667 CA242552833	642	E>D		No	ClinGen ESP TOPMed gnomAD
rs754939231 CA6753743	644	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA6753745 rs200619766	649	A>P		No	ClinGen ExAC gnomAD
rs770239470 CA6753749	653	G>A		No	ClinGen ExAC gnomAD
CA6753748 rs748492752	653	G>R		No	ClinGen ExAC gnomAD
CA6753750 rs773705690	655	S>A		No	ClinGen ExAC gnomAD
rs1566167847 CA386329752	655	S>C		No	ClinGen Ensembl
CA242552870 rs3209749	657	N>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs748763994 CA6753751	657	N>S		No	ClinGen ExAC gnomAD
CA6753752 rs770625043	658	M>T		No	ClinGen ExAC gnomAD
rs1593492108 CA386329815	659	E>G		No	ClinGen Ensembl
rs924455319 CA242552884	661	I>L		No	ClinGen Ensembl
rs1593492114 CA386329872	662	M>K		No	ClinGen Ensembl
rs767257687 CA6753755	669	T>M		No	ClinGen ExAC TOPMed gnomAD
CA386330053 rs1284448868	672	D>N		No	ClinGen gnomAD
CA6753757 rs760451741	673	I>V		No	ClinGen ExAC gnomAD
CA386330123 rs1193613717	675	T>I		No	ClinGen gnomAD
CA386330133 rs1305995754	676	N>T		No	ClinGen TOPMed
rs373656293 CA242557329	679	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA TOPMed gnomAD
CA386331685 rs367709041	680	S>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs367709041 CA6753784	680	S>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	681	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs778242700 CA6753785	681	Q>P		No	ClinGen ExAC gnomAD
rs144295543 CA6753786	684	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs577690613 CA6753787	689	P>S		No	ClinGen ExAC gnomAD
CA386331804 rs1365409333	690	R>K		No	ClinGen gnomAD
CA6753789 rs372636341	692	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs768168995 CA6753793	694	I>T		No	ClinGen ExAC gnomAD
rs980541195 CA242557350	695	R>K		No	ClinGen Ensembl
CA6753795 rs776430209	695	R>S		No	ClinGen ExAC TOPMed gnomAD
CA6753796 rs553845953	696	D>E		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	699	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM934198 rs769723826 CA6753797	699	R>Q	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA386331906 rs773080167	700	R>L		No	ClinGen ExAC TOPMed gnomAD
rs773080167 CA6753798	700	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs374724193 CA242557357	701	I>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs374724193 CA6753799	701	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs962400260 CA386331930	702	K>N		No	ClinGen TOPMed
CA242557391 rs956056573	705	E>A		No	ClinGen TOPMed
CA242557389 rs200307600	705	E>K		No	ClinGen 1000Genomes
rs780752923 CA6753816	706	D>H		No	ClinGen ExAC TOPMed gnomAD
CA242557396 rs780752923	706	D>N		No	ClinGen ExAC TOPMed gnomAD
CA6753817 rs747953980	708	K>I		No	ClinGen ExAC gnomAD
CA6753818 rs769638805	709	T>A		No	ClinGen ExAC gnomAD
CA386332053 rs1375463361	709	T>I		No	ClinGen TOPMed
TCGA novel	709	T>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386332079 rs1434244856	712	D>N		No	ClinGen gnomAD
rs943439192 CA242557400	713	L>P		No	ClinGen Ensembl
TCGA novel	714	A>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6753819 rs555733986	716	V>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6753820 rs749290700	718	F>S		No	ClinGen ExAC gnomAD
rs1289464030 CA386332202	719	E>Q		No	ClinGen gnomAD
rs1355227279 CA386332246	722	T>A		No	ClinGen gnomAD
CA242557405 rs576372064	722	T>M		No	ClinGen 1000Genomes gnomAD
rs760632547 CA386332267	724	R>L		No	ClinGen ExAC TOPMed gnomAD
CA6753823 rs760632547	724	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs770752783 CA6753821 COSM1746693	724	R>W	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA386332287 rs1298442971	726	G>W		No	ClinGen gnomAD
CA6753824 rs764417541	729	L>F		No	ClinGen ExAC gnomAD
rs765735543 CA6753827	734	A>S		No	ClinGen ExAC TOPMed gnomAD
rs369072974 CA6753828	735	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs766753059 CA6753830	737	D>Y		No	ClinGen ExAC gnomAD
CA386332581 rs1424025856	741	R>S		No	ClinGen gnomAD
rs751081426 CA6753831	744	R>C		No	ClinGen ExAC TOPMed gnomAD
rs754385043 CA6753832	744	R>H		No	ClinGen ExAC TOPMed gnomAD
CA6753834 rs188648559	747	L>F		No	ClinGen 1000Genomes ExAC
CA6753835 rs142406645	748	N>K		No	ClinGen ESP ExAC gnomAD
CA386332775 rs1375321125	750	D>E		No	ClinGen gnomAD
rs748988664 CA6753837	752	D>V		No	ClinGen ExAC gnomAD
CA386332816 rs1380248702	753	A>S		No	ClinGen gnomAD
rs1381846115 CA386332820	753	A>V		No	ClinGen gnomAD
CA386332835 rs1220841786	754	K>M		No	ClinGen TOPMed gnomAD
CA386332825 rs1566168803	754	K>Q		No	ClinGen Ensembl
rs1302766405 CA386332858	755	V>L		No	ClinGen gnomAD
rs767056897 CA6753853	756	E>K		No	ClinGen ExAC TOPMed gnomAD
rs767056897 CA386332862	756	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA6753855 rs755787354	758	E>G		No	ClinGen ExAC gnomAD
CA6753857 rs753671495	760	E>K		No	ClinGen ExAC TOPMed gnomAD
CA242557546 rs140225827	761	E>G		No	ClinGen ESP TOPMed
CA386332910 rs1593493780	762	E>D		No	ClinGen Ensembl
rs376271632 CA6753858	763	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1238823762 CA386332925	765	E>K		No	ClinGen TOPMed
rs1371151116 CA386332938	766	T>I		No	ClinGen TOPMed
rs200650067 CA242557550	767	A>E		No	ClinGen Ensembl
rs370313687 CA6753860	767	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed
rs1476720153 CA386332946	768	E>G		No	ClinGen gnomAD
rs745833035 CA6753861	768	E>K		No	ClinGen ExAC gnomAD
CA6753862 rs776861206	769	D>G		No	ClinGen ExAC TOPMed gnomAD
CA386332961 rs1420772924	770	T>I		No	ClinGen TOPMed
rs1426437528 CA386332958	770	T>P		No	ClinGen gnomAD
CA242557561 rs569291244	771	T>A		No	ClinGen 1000Genomes TOPMed
rs781442255 CA6753863	771	T>I		No	ClinGen ExAC
rs1036233143 CA242557563	772	E>A		No	ClinGen TOPMed
CA6753864 rs748195956	773	D>N		No	ClinGen ExAC gnomAD
CA6753865 rs770142573	774	T>A		No	ClinGen ExAC gnomAD
CA386332983 rs535057154	774	T>I		No	ClinGen 1000Genomes ExAC gnomAD
rs535057154 CA6753866	774	T>K		No	ClinGen 1000Genomes ExAC gnomAD
rs1348210757 CA386332991	775	E>D		No	ClinGen TOPMed gnomAD
TCGA novel	775	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs760087578 COSM934200 CA6753870	778	E>K	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA6753871 rs767966985	780	E>*		No	ClinGen ExAC gnomAD
rs1245850445 CA386333032	780	E>D		No	ClinGen TOPMed
TCGA novel	782	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs144178041 CA6753872	782	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1286221590 CA386333051	783	D>H		No	ClinGen TOPMed gnomAD
rs760113921 CA6753873	785	G>E		No	ClinGen ExAC TOPMed gnomAD
rs1272069908	787	D>missing	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA386333090 CA386333089 rs1223103257	788	E>D		No	ClinGen gnomAD
TCGA novel	788	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA242557586 rs910493716	790	E>K		No	ClinGen gnomAD
rs910493716 CA242557588	790	E>Q		No	ClinGen gnomAD
rs763820579 CA6753875	791	E>A		No	ClinGen ExAC TOPMed gnomAD
CA242557591 rs199613394	791	E>K		No	ClinGen Ensembl
rs199613394 CA242557593	791	E>Q		No	ClinGen Ensembl
rs753493088 CA6753876	794	K>Q		No	ClinGen ExAC TOPMed gnomAD
CA242557654 rs372146745	795	E>A		No	ClinGen gnomAD
rs1356183173 CA386333145	795	E>D		No	ClinGen TOPMed gnomAD
rs1333261091 CA386333158	797	T>I		No	ClinGen gnomAD
CA6753904 rs751610640	798	A>P		No	ClinGen ExAC TOPMed gnomAD
rs751610640 CA386333159	798	A>T		No	ClinGen ExAC TOPMed gnomAD
CA386333164 rs1472159708	799	E>K		No	ClinGen TOPMed
rs777767051 CA6753906	801	D>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA386333189 rs1340884541	802	E>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	803	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA

No associated diseases with P14625

3 regional properties for P14625

Type	Name	Position	InterPro Accession
domain	Histidine kinase/HSP90-like ATPase	96 - 255	IPR003594
conserved_site	Heat shock protein Hsp90, conserved site	94 - 103	IPR019805
domain	Heat shock protein Hsp90, N-terminal	74 - 279	IPR020575

Functions

		Description
EC Number
Subcellular Localization	Endoplasmic reticulum lumen Sarcoplasmic reticulum lumen Melanosome	Identified by mass spectrometry in melanosome fractions from stage I to stage IV
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

18 GO annotations of cellular component

Name	Definition
collagen-containing extracellular matrix	An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endocytic vesicle lumen	The volume enclosed by the membrane of an endocytic vesicle.
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum chaperone complex	A protein complex that is located in the endoplasmic reticulum and is composed of chaperone proteins, including BiP, GRP94; CaBP1, protein disulfide isomerase (PDI), ERdj3, cyclophilin B, ERp72, GRP170, UDP-glucosyltransferase, and SDF2-L1.
endoplasmic reticulum lumen	The volume enclosed by the membranes of the endoplasmic reticulum.
endoplasmic reticulum membrane	The lipid bilayer surrounding the endoplasmic reticulum.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
extracellular region	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
focal adhesion	A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ).
melanosome	A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
midbody	A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
perinuclear region of cytoplasm	Cytoplasm situated near, or occurring around, the nucleus.
protein-containing complex	A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
sarcoplasmic reticulum lumen	The volume enclosed by the membranes of the sarcoplasmic reticulum.
sperm plasma membrane	A plasma membrane that is part of a sperm cell.

8 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity	Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
ATP-dependent protein folding chaperone	Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis.
calcium ion binding	Binding to a calcium ion (Ca2+).
low-density lipoprotein particle receptor binding	Binding to a low-density lipoprotein receptor.
protein phosphatase binding	Binding to a protein phosphatase.
RNA binding	Binding to an RNA molecule or a portion thereof.
unfolded protein binding	Binding to an unfolded protein.

12 GO annotations of biological process

Name	Definition
actin rod assembly	The assembly of actin rods, a cellular structure consisting of parallel, hexagonally arranged actin tubules.
cellular response to ATP	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus.
negative regulation of apoptotic process	Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
protein folding	The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
protein folding in endoplasmic reticulum	A protein folding process that takes place in the endoplasmic reticulum (ER). Secreted, plasma membrane and organelle proteins are folded in the ER, assisted by chaperones and foldases (protein disulphide isomerases), and additional factors required for optimal folding (ATP, Ca2+ and an oxidizing environment to allow disulfide bond formation).
protein transport	The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
regulation of phosphoprotein phosphatase activity	Any process that modulates the frequency, rate or extent of phosphoprotein phosphatase activity, the catalysis of the hydrolysis of phosphate from a phosphoprotein.
response to endoplasmic reticulum stress	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.
response to hypoxia	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
retrograde protein transport, ER to cytosol	The directed movement of unfolded or misfolded proteins from the endoplasmic reticulum to the cytosol through the translocon.
sequestering of calcium ion	The process of binding or confining calcium ions such that they are separated from other components of a biological system.
ubiquitin-dependent ERAD pathway	The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P08113	Hsp90b1	Endoplasmin	Mus musculus (Mouse)	PR
Q66HD0	Hsp90b1	Endoplasmin	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MRALWVLGLC	CVLLTFGSVR	ADDEVDVDGT	VEEDLGKSRE	GSRTDDEVVQ	REEEAIQLDG
70	80	90	100	110	120
LNASQIRELR	EKSEKFAFQA	EVNRMMKLII	NSLYKNKEIF	LRELISNASD	ALDKIRLISL
130	140	150	160	170	180
TDENALSGNE	ELTVKIKCDK	EKNLLHVTDT	GVGMTREELV	KNLGTIAKSG	TSEFLNKMTE
190	200	210	220	230	240
AQEDGQSTSE	LIGQFGVGFY	SAFLVADKVI	VTSKHNNDTQ	HIWESDSNEF	SVIADPRGNT
250	260	270	280	290	300
LGRGTTITLV	LKEEASDYLE	LDTIKNLVKK	YSQFINFPIY	VWSSKTETVE	EPMEEEEAAK
310	320	330	340	350	360
EEKEESDDEA	AVEEEEEEKK	PKTKKVEKTV	WDWELMNDIK	PIWQRPSKEV	EEDEYKAFYK
370	380	390	400	410	420
SFSKESDDPM	AYIHFTAEGE	VTFKSILFVP	TSAPRGLFDE	YGSKKSDYIK	LYVRRVFITD
430	440	450	460	470	480
DFHDMMPKYL	NFVKGVVDSD	DLPLNVSRET	LQQHKLLKVI	RKKLVRKTLD	MIKKIADDKY
490	500	510	520	530	540
NDTFWKEFGT	NIKLGVIEDH	SNRTRLAKLL	RFQSSHHPTD	ITSLDQYVER	MKEKQDKIYF
550	560	570	580	590	600
MAGSSRKEAE	SSPFVERLLK	KGYEVIYLTE	PVDEYCIQAL	PEFDGKRFQN	VAKEGVKFDE
610	620	630	640	650	660
SEKTKESREA	VEKEFEPLLN	WMKDKALKDK	IEKAVVSQRL	TESPCALVAS	QYGWSGNMER
670	680	690	700	710	720
IMKAQAYQTG	KDISTNYYAS	QKKTFEINPR	HPLIRDMLRR	IKEDEDDKTV	LDLAVVLFET
730	740	750	760	770	780
ATLRSGYLLP	DTKAYGDRIE	RMLRLSLNID	PDAKVEEEPE	EEPEETAEDT	TEDTEQDEDE
790	800
EMDVGTDEEE	ETAKESTAEK	DEL