P14180
Gene name |
CHS2 (YBR038W, YBR0407) |
Protein name |
Chitin synthase 2 |
Names |
Chitin-UDP acetyl-glucosaminyl transferase 2 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YBR038W |
EC number |
2.4.1.16: Hexosyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P14180
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P14180-F1 | Predicted | AlphaFoldDB |
4 variants for P14180
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s02-313152 | 419 | N>T | No | SGRP | |
| s02-313199 | 435 | T>A | No | SGRP | |
| s02-314072 | 726 | C>G | No | SGRP | |
| s02-314678 | 928 | F>V | No | SGRP |
No associated diseases with P14180
No regional properties for P14180
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P14180 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 2.4.1.16 | Hexosyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell periphery | The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures. |
| cell septum | A structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells. |
| cellular bud neck | The constriction between the mother cell and daughter cell (bud) in an organism that reproduces by budding. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| chitin synthase activity | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + [->4)-N-acetyl-beta-D-glucosaminyl-(1-](n) = UDP + [->4)-N-acetyl-beta-D-glucosaminyl-(1-](n+1). |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| cell wall chitin biosynthetic process | The chemical reactions and pathways resulting in the formation of cell wall chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in the walls of cells. |
| cell wall organization | A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. |
| chitin biosynthetic process | The chemical reactions and pathways resulting in the formation of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues. |
| mitotic actomyosin contractile ring maintenance | Any actomyosin contractile ring maintenance that is involved in mitotic cell cycle. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P08004 | CHS1 | Chitin synthase 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTRNPFMVEP | SNGSPNRRGA | SNLSKFYANA | NSNSRWANPS | EESLEDSYDQ | SNVFQGLPAS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PSRAALRYSP | DRRHRTQFYR | DSAHNSPVAP | NRYAANLQES | PKRAGEAVIH | LSEGSNLYPR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DNADLPVDPY | HLSPQQQPSN | NLFGSGRLYS | QSSKYTMSTT | STTAPSLAEA | DDEKEKYLTS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TTSYDDQSTI | FSADTFNETK | FELNHPTRQQ | YVRRANSESK | RRMVSDLPPP | SKKKALLKLD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NPIPKGLLDT | LPRRNSPEFT | EMRYTACTVE | PDDFLREGYT | LRFAEMNREC | QIAICITMYN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EDKYSLARTI | HSIMKNVAHL | CKREKSHVWG | PNGWKKVSVI | LISDGRAKVN | QGSLDYLAAL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GVYQEDMAKA | SVNGDPVKAH | IFELTTQVSI | NADLDYVSKD | IVPVQLVFCL | KEENKKKINS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| HRWLFNAFCP | VLQPTVVTLV | DVGTRLNNTA | IYRLWKVFDM | DSNVAGAAGQ | IKTMKGKWGL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KLFNPLVASQ | NFEYKISNIL | DKPLESVFGY | ISVLPGALSA | YRYRALKNHE | DGTGPLRSYF |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LGETQEGRDH | DVFTANMYLA | EDRILCWELV | AKRDAKWVLK | YVKEATGETD | VPEDVSEFIS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| QRRRWLNGAM | FAAIYAQLHF | YQIWKTKHSV | VRKFFLHVEF | LYQFIQMLFS | WFSIANFVLT |
| 670 | 680 | 690 | 700 | 710 | 720 |
| FYYLAGSMNL | VIKHGEALFI | FFKYLIFCDL | ASLFIISMGN | RPQGAKHLFI | TSMVILSICA |
| 730 | 740 | 750 | 760 | 770 | 780 |
| TYSLICGFVF | AFKSLASGTE | SHKIFVDIVI | SLLSTYGLYF | FSSLMYLDPW | HMFTSSIQYF |
| 790 | 800 | 810 | 820 | 830 | 840 |
| LTLPAFTCTL | QIFAFCNTHD | VSWGTKGSTQ | ESKQLSKAIV | VQGPDGKQIV | ETDWPQEVDK |
| 850 | 860 | 870 | 880 | 890 | 900 |
| KFLEIKSRLK | EPEFEESSGN | EKQSKNDYYR | DIRTRIVMIW | MLSNLILIMS | IIQVFTPQDT |
| 910 | 920 | 930 | 940 | 950 | 960 |
| DNGYLIFILW | SVAALAAFRV | VGSMAFLFMK | YLRIIVSYRN | KVEGSGSWEV | SKLDLPNVFH |
| KKG |