AiPD: Autoinhibited Protein Database

Gene name	CHS1 (YNL192W, N1404)
Protein name	Chitin synthase 1
Names	Chitin-UDP acetyl-glucosaminyl transferase 1
Species	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway	sce:YNL192W
EC number	2.4.1.16: Hexosyltransferases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

134-258 (Predicted disordered autoinhibitory region) PR

134-258 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
7XS6	EM	290 A	A/B	1-1131	PDB
7XS7	EM	320 A	A/B	1-1131	PDB
8K3P	EM	364 A	A/B	1-1131	PDB
8K3Q	EM	260 A	A/B	1-1131	PDB
8K3R	EM	351 A	A/B	1-1131	PDB
8K3T	EM	357 A	A/B	1-1131	PDB
8K3U	EM	306 A	A/B	1-1131	PDB
8K3V	EM	310 A	A/B	1-1131	PDB
8K3W	EM	291 A	A/B	1-1131	PDB
8K3X	EM	286 A	A/B	1-1131	PDB
AF-P08004-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
s14-276551	17	K>E	No	SGRP
s14-276738	79	D>G	No	SGRP
s14-276765	88	N>T	No	SGRP
s14-276800	100	H>Y	No	SGRP
s14-276825	108	T>I	No	SGRP
s14-277215	238	E>G	No	SGRP
s14-277313	271	L>I	No	SGRP
s14-277335	278	E>V	No	SGRP
s14-277360	286	D>E	No	SGRP
s14-277362	287	S>N	No	SGRP
s14-277363	287	S>R	No	SGRP
s14-277455	318	S>L	No	SGRP
s14-277529	343	S>T	No	SGRP
s14-277601	367	A>T	No	SGRP
s14-278141	547	T>A	No	SGRP
s14-278274	591	E>G	No	SGRP
s14-279747	1082	A>V	No	SGRP
s14-279866	1122	V>L	No	SGRP
s14-279881	1127	K>E	No	SGRP
s14-279882	1127	K>R	No	SGRP

Type	Name	Position	InterPro Accession
domain	Chitin synthase N-terminal	376 - 453	IPR013616

		Description
EC Number	2.4.1.16	Hexosyltransferases
Subcellular Localization	Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cell periphery	The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
cell septum	A structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells.
chitosome	An intracellular membrane-bounded particle found in fungi and containing chitin synthase; it synthesizes chitin microfibrils. Chitin synthase activity exists in chitosomes and they are proposed to act as a reservoir for regulated transport of chitin synthase enzymes to the division septum.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Name	Definition
chitin synthase activity	Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + [->4)-N-acetyl-beta-D-glucosaminyl-(1-](n) = UDP + [->4)-N-acetyl-beta-D-glucosaminyl-(1-](n+1).

Name	Definition
cell wall chitin biosynthetic process	The chemical reactions and pathways resulting in the formation of cell wall chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in the walls of cells.
cell wall organization	A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis.
septum digestion after cytokinesis	The process of physically separating the septal cell wall material by enzymatic digestion, that occurs after daughter cells are separated by cytokinesis.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P14180	CHS2	Chitin synthase 2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR