P12687

PR
Gene name
MRP7 (MRPL2, YNL005C, N2007)
Protein name
54S ribosomal protein L2, mitochondrial
Names
Mitochondrial large ribosomal subunit protein bL27m, YMR6, YmL2
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YNL005C
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-85 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

5 structures for P12687

Entry ID Method Resolution Chain Position Source
3J6B EM 320 A R 1-371 PDB
5MRC EM 325 A R 35-371 PDB
5MRE EM 375 A R 35-371 PDB
5MRF EM 497 A R 35-371 PDB
AF-P12687-F1 Predicted AlphaFoldDB

4 variants for P12687

Variant ID(s) Position Change Description Diseaes Association Provenance
s14-621695 246 K>E No SGRP
s14-621629 268 Q>K No SGRP
s14-621530 301 I>V No SGRP
s14-621430 334 S>N No SGRP

No associated diseases with P12687

2 regional properties for P12687

Type Name Position InterPro Accession
conserved_site Ribosomal protein L27, conserved site 60 - 74 IPR018261
domain Ribosomal L27 protein, C-terminal 135 - 371 IPR041244

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion
  • Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial large ribosomal subunit The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site).
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

1 GO annotations of molecular function

Name Definition
structural constituent of ribosome The action of a molecule that contributes to the structural integrity of the ribosome.

1 GO annotations of biological process

Name Definition
mitochondrial translation The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O65037 RPL27 50S ribosomal protein L27, chloroplastic Oryza sativa subsp japonica (Rice) PR
Q9FLN4 RPL27 50S ribosomal protein L27, chloroplastic Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MWNPILLDTS SFSFQKHVSG VFLQVRNATK RAAGSRTSMK DSAGRRLGPK KYEGQDVSTG
70 80 90 100 110 120
EIIMRQRGTK FYPGENVGIG KDHSIFALEP GVVRYYLDPF HPKRKFIGVA LRRDLKLPSP
130 140 150 160 170 180
HFEPTVRRFG RFELTNKRAA YKEENSISRK DYLAKPNILK QLEVRESKRK ELQDKLSKVL
190 200 210 220 230 240
RDELKLDIKD IELATSYLIR VRASLKNGYP IEDARFNSRY YLKEEERLKA RRESWTNEKL
250 260 270 280 290 300
SESLSKIDEC SDLLNSSTSF NNKLELHQYI SEQEKQALKA KLLEDLEKSQ HLETKKDKNY
310 320 330 340 350 360
IKALFKDACN FLTLSEEVHL RRKYLKSVFP ETDSTVETKS GKKSIVSRRF DYTKNKVEVI
370
ARSRRAFLSK L