P12637

PR
Gene name
CASQ2
Protein name
Calsequestrin-2
Names
Calsequestrin, cardiac muscle isoform
Species
Canis lupus familiaris (Dog) (Canis familiaris)
KEGG Pathway
cfa:483134
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

361-410 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for P12637

Entry ID Method Resolution Chain Position Source
1SJI X-ray 240 A A/B 22-371 PDB
AF-P12637-F1 Predicted AlphaFoldDB

No variants for P12637

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P12637

No associated diseases with P12637

5 regional properties for P12637

Type Name Position InterPro Accession
conserved_site Calsequestrin, conserved site 20 - 34 IPR018233-1
conserved_site Calsequestrin, conserved site 357 - 376 IPR018233-2
domain Calsequestrin, middle TRX-fold domain 145 - 246 IPR041858
domain Calsequestrin, N-terminal TRX-fold domain 24 - 143 IPR041859
domain Calsequestrin, C-terminal TRX-fold domain 247 - 366 IPR041860

Functions

Description
EC Number
Subcellular Localization
  • Sarcoplasmic reticulum lumen
  • This isoform of calsequestrin occurs in the sarcoplasmic reticulum's terminal cisternae luminal spaces of cardiac and slow skeletal muscle cells
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
sarcoplasmic reticulum A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage.
sarcoplasmic reticulum lumen The volume enclosed by the membranes of the sarcoplasmic reticulum.
Z disc Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.

1 GO annotations of molecular function

Name Definition
calcium ion binding Binding to a calcium ion (Ca2+).

4 GO annotations of biological process

Name Definition
negative regulation of ryanodine-sensitive calcium-release channel activity Any process that decreases the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts.
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion Any process that modulates the frequency, rate or extent of cardiac muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction.
regulation of release of sequestered calcium ion into cytosol Any process that modulates the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria.
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Any process that modulates the rate, frequency or extent of release of sequestered calcium ion into cytosol by the sarcoplasmic reticulum, the process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O14958 CASQ2 Calsequestrin-2 Homo sapiens (Human) PR
O09161 Casq2 Calsequestrin-2 Mus musculus (Mouse) PR
P51868 Casq2 Calsequestrin-2 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MKRTHLFIAG LYLLASCRAE EGLNFPTYDG KDRVVSLTEK NFKQVLKKYD VLCLYYHESV
70 80 90 100 110 120
SSDKVAQKQF QLKEIVLELV AQVLEHKDIG FVMVDAKKEA KLAKKLGFDE EGSLYVLKGD
130 140 150 160 170 180
RTIEFDGEFA ADVLVEFLLD LIEDPVEIIN SKLEVQAFER IEDQIKLIGF FKSEESEYYK
190 200 210 220 230 240
AFEEAAEHFQ PYIKFFATFD KGVAKKLSLK MNEVDFYEPF MDEPIAIPDK PYTEEELVEF
250 260 270 280 290 300
VKEHQRPTLR RLRPEDMFET WEDDLNGIHI VAFAERSDPD GYEFLEILKQ VARDNTDNPD
310 320 330 340 350 360
LSIVWIDPDD FPLLVAYWEK TFKIDLFKPQ IGVVNVTDAD SVWMEIPDDD DLPTAEELED
370 380 390 400
WIEDVLSGKI NTEDDDNEEG DDGDDDEDDD DDDGNNSDEE SNDDSDDDDE