P12378

PR
Gene name
UGDH
Protein name
UDP-glucose 6-dehydrogenase
Names
UDP-Glc dehydrogenase, UDP-GlcDH, UDPGDH
Species
Bos taurus (Bovine)
KEGG Pathway
bta:281564
EC number
1.1.1.22: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

437-494 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P12378

Entry ID Method Resolution Chain Position Source
AF-P12378-F1 Predicted AlphaFoldDB

57 variants for P12378

Variant ID(s) Position Change Description Diseaes Association Provenance
rs449633032 31 R>S No EVA
rs478168875 57 L>R No EVA
rs458903256 58 K>E No EVA
rs438832498 59 E>K No EVA
rs207574221 74 N>S No EVA
rs463101717 82 A>P No EVA
rs458554420 106 L>R No EVA
rs722103354 115 R>C No EVA
rs468477965 122 G>R No EVA
rs449256428 143 I>V No EVA
rs435627736 148 T>A No EVA
rs451002705 160 P>S No EVA
rs462330329 169 I>M No EVA
rs473012521 171 D>Y No EVA
rs459366180 177 R>G No EVA
rs439259172 180 I>F No EVA
rs470687798 183 D>E No EVA
rs474895268 220 K>Q No EVA
rs463542334 224 N>K No EVA
rs134658326 251 V>G No EVA
rs136239800 253 T>P No EVA
rs475109105 257 M>R No EVA
rs434965665 260 R>G No EVA
rs472804907 262 G>A No EVA
rs472804907 262 G>V No EVA
rs452752545 263 N>H No EVA
rs432599011 269 S>R No EVA
rs466869325 275 S>G No EVA
rs446670669 275 S>N No EVA
rs433070791 278 Q>P No EVA
rs445264950 281 V>F No EVA
rs463058173 296 V>A No EVA
rs449442404 302 Q>L No EVA
rs473173539 348 S>* No EVA
rs433207573 350 S>G No EVA
rs470946921 350 S>N No EVA
rs457464746 351 I>L No EVA
rs437419800 351 I>R No EVA
rs468831787 361 G>S No EVA
rs448727522 363 H>L No EVA
rs435097055 374 E>G No EVA
rs445673822 377 V>G No EVA
rs465716418 377 V>I No EVA
rs477091825 379 D>A No EVA
rs463514774 380 L>P No EVA
rs481296919 389 D>G No EVA
rs453648090 391 V>G No EVA
rs433671441 396 T>S No EVA
rs437880538 414 C>F No EVA
rs469303734 417 W>G No EVA
rs3423224916 449 H>R No EVA
rs460711953 466 V>G No EVA
rs439948025 476 S>P No EVA
rs457766098 477 G>C No EVA
rs475554570 479 I>S No EVA
rs455441296 483 S>G No EVA
rs441889157 494 V>A No EVA

No associated diseases with P12378

3 regional properties for P12378

Type Name Position InterPro Accession
domain UDP-glucose/GDP-mannose dehydrogenase, N-terminal 6 - 190 IPR001732
domain UDP-glucose/GDP-mannose dehydrogenase, dimerisation 214 - 308 IPR014026
domain UDP-glucose/GDP-mannose dehydrogenase, C-terminal 332 - 447 IPR014027

Functions

Description
EC Number 1.1.1.22 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
identical protein binding Binding to an identical protein or proteins.
NAD binding Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.
UDP-glucose 6-dehydrogenase activity Catalysis of the reaction: H(2)O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate.

8 GO annotations of biological process

Name Definition
carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
chondroitin sulfate biosynthetic process The chemical reactions and pathways resulting in the formation of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate.
gastrulation with mouth forming second A gastrulation process in which the initial invagination becomes the anus and the mouth forms second.
glycosaminoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars.
heparan sulfate proteoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues.
neuron development The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
protein hexamerization The formation of a protein hexamer, a macromolecular structure consisting of six noncovalently associated identical or nonidentical subunits.
UDP-glucuronate biosynthetic process The chemical reactions and pathways resulting in the formation of UDP-glucuronate, a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5F3T9 UGDH UDP-glucose 6-dehydrogenase Gallus gallus (Chicken) PR
O60701 UGDH UDP-glucose 6-dehydrogenase Homo sapiens (Human) PR
O70475 Ugdh UDP-glucose 6-dehydrogenase Mus musculus (Mouse) PR
O70199 Ugdh UDP-glucose 6-dehydrogenase Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MFEIKKICCI GAGYVGGPTC SVIAHMCPEI RVTVVDINES RINAWNSPTL PIYEPGLKEV
70 80 90 100 110 120
VESCRGKNLF FSTNIDDAIK EADLVFISVN TPTKTYGMGK GRAADLKYIE ACARRIVQNS
130 140 150 160 170 180
HGYKIVTEKS TVPVRAAESI RRIFDANTKP NLNLQVLSNP EFLAEGTAIK DLKNPDRVLI
190 200 210 220 230 240
GGDETPEGQR AVQALCAVYE HWVPREKILT TNTWSSELSK LTANAFLAQR ISSINSISAL
250 260 270 280 290 300
CEATGADVEE VATAIGMDQR IGNKFLKASV GFGGSCFQKD VLNLVYLCEA LNLPEVARYW
310 320 330 340 350 360
QQVIDMNDYQ RRRFASRIID SLFNTVTDKK IAILGFAFKK DTGDTRESSS IYISKYLMDE
370 380 390 400 410 420
GAHLHIYDPK VPREQIVVDL SHPGVSKDDQ VARLVTISKD PYEACDGAHA VVICTEWDMF
430 440 450 460 470 480
KELDYERIHK KMLKPAFIFD GRRVLDGLHN ELQTIGFQIE TIGKKVSSKR IPYAPSGEIP
490
KFSLQDMPNK KPRV