O70475
PR
Gene name |
Ugdh |
Protein name |
UDP-glucose 6-dehydrogenase |
Names |
UDP-Glc dehydrogenase, UDP-GlcDH, UDPGDH |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:22235 |
EC number |
1.1.1.22: With NAD(+) or NADP(+) as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O70475
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O70475-F1 | Predicted | AlphaFoldDB |
19 variants for O70475
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388764021 | 62 | E>D | No | EVA | |
| rs3388758474 | 74 | N>Y | No | EVA | |
| rs3388763433 | 133 | P>H | No | EVA | |
| rs3388744353 | 204 | P>L | No | EVA | |
| rs3388755971 | 241 | C>Y | No | EVA | |
| rs3388755972 | 251 | V>M | No | EVA | |
| rs3388759898 | 263 | N>D | No | EVA | |
| rs3388748587 | 264 | K>R | No | EVA | |
| rs3388755933 | 275 | S>G | No | EVA | |
| rs3388763607 | 281 | V>G | No | EVA | |
| rs3388766074 | 296 | V>A | No | EVA | |
| rs3388751563 | 296 | V>L | No | EVA | |
| rs3388759893 | 354 | S>G | No | EVA | |
| rs3412986286 | 370 | K>R | No | EVA | |
| rs3395630191 | 381 | S>A | No | EVA | |
| rs3388758468 | 383 | P>Q | No | EVA | |
| rs3388756324 | 415 | T>I | No | EVA | |
| rs3388748612 | 480 | K>N | No | EVA | |
| rs3388764003 | 489 | K>N | No | EVA |
No associated diseases with O70475
3 regional properties for O70475
Functions
| Description | ||
|---|---|---|
| EC Number | 1.1.1.22 | With NAD(+) or NADP(+) as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| identical protein binding | Binding to an identical protein or proteins. |
| NAD binding | Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. |
| UDP-glucose 6-dehydrogenase activity | Catalysis of the reaction: H(2)O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| carbohydrate metabolic process | The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. |
| chondroitin sulfate biosynthetic process | The chemical reactions and pathways resulting in the formation of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. |
| gastrulation with mouth forming second | A gastrulation process in which the initial invagination becomes the anus and the mouth forms second. |
| glycosaminoglycan biosynthetic process | The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars. |
| heparan sulfate proteoglycan biosynthetic process | The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues. |
| neuron development | The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. |
| protein hexamerization | The formation of a protein hexamer, a macromolecular structure consisting of six noncovalently associated identical or nonidentical subunits. |
| UDP-glucuronate biosynthetic process | The chemical reactions and pathways resulting in the formation of UDP-glucuronate, a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P12378 | UGDH | UDP-glucose 6-dehydrogenase | Bos taurus (Bovine) | PR |
| Q5F3T9 | UGDH | UDP-glucose 6-dehydrogenase | Gallus gallus (Chicken) | PR |
| O60701 | UGDH | UDP-glucose 6-dehydrogenase | Homo sapiens (Human) | PR |
| O70199 | Ugdh | UDP-glucose 6-dehydrogenase | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVEIKKICCI | GAGYVGGPTC | SVIAHMCPEI | RVTVVDVNEA | RINAWNSPTL | PIYEPGLKEV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VESCRGKNLF | FSTNIDDAIR | EADLVFISVN | TPTKTYGMGK | GRAADLKYIE | ACARRIVQNS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NGYKIVTEKS | TVPVRAAESI | RRIFDANTKP | NLNLQVLSNP | EFLAEGTAIK | DLKNPDRVLI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GGDETPEGQK | AVRALCAVYE | HWVPKEKILT | TNTWSSELSK | LAANAFLAQR | ISSINSISAL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| CEATGADVEE | VATAIGMDQR | IGNKFLKASV | GFGGSCFQKD | VLNLVYLCEA | LNLPEVARYW |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QQVIDMNDYQ | RRRFASRIID | SLFNTVTDKK | IAILGFAFKK | DTGDTRESSS | IYISKYLMDE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GAHLHIYDPK | VPREQIVVDL | SHPGVSADDQ | VSRLVTISKD | PYEACDGAHA | LVICTEWDMF |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KELDYERIHK | KMLKPAFIFD | GRRVLDGLHS | ELQTIGFQIE | TIGKKVSSKR | IPYTPGEIPK |
| 490 | |||||
| FSLQDPPNKK | PKV |