P0C0K7
SS
Gene name |
Ephb6 |
Protein name |
Ephrin type-B receptor 6 |
Names |
Tyrosine-protein kinase-defective receptor EPH-6 |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:312275 |
EC number |
|
Protein Class |
|
Descriptions
Ephrin type-B receptor 2 is a membrane-associated protein that mediates axon guidance, cell migration and morphogenesis. The Eph receptor tyrosine kinase family is regulated by autophosphorylation within the juxtamembrane region and the kinase activation segment. The structure, supported by mutagenesis data, reveals that the juxtamembrane segment adopts a helical conformation that distorts the small lobe of the kinase domain, and blocks the activation segment from attaining an activated conformation. Phosphorylation of the conserved juxtamembrane tyrosines would relieve this autoinhibition by disturbing the association of the juxtamembrane segment with the kinase domain, while liberating phosphotyrosine sites for binding SH2 domains of target proteins.
Autoinhibitory domains (AIDs)
Target domain |
662-911 (Protein kinase domain) |
Relief mechanism |
PTM |
Assay |
|
Accessory elements
No accessory elements
References
Autoinhibited structure
Activated structure
1 structures for P0C0K7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P0C0K7-F1 | Predicted | AlphaFoldDB |
No variants for P0C0K7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P0C0K7 | |||||
No associated diseases with P0C0K7
41 regional properties for P0C0K7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 1464 - 1719 | IPR000719 |
| domain | Immunoglobulin subtype 2 | 45 - 113 | IPR003598-1 |
| domain | Immunoglobulin subtype 2 | 173 - 240 | IPR003598-2 |
| domain | Immunoglobulin subtype 2 | 426 - 494 | IPR003598-3 |
| domain | Immunoglobulin subtype 2 | 526 - 590 | IPR003598-4 |
| domain | Immunoglobulin subtype 2 | 635 - 702 | IPR003598-5 |
| domain | Immunoglobulin subtype 2 | 733 - 801 | IPR003598-6 |
| domain | Immunoglobulin subtype 2 | 1110 - 1177 | IPR003598-7 |
| domain | Immunoglobulin subtype 2 | 1250 - 1317 | IPR003598-8 |
| domain | Immunoglobulin subtype 2 | 1821 - 1889 | IPR003598-9 |
| domain | Immunoglobulin subtype | 39 - 124 | IPR003599-1 |
| domain | Immunoglobulin subtype | 167 - 251 | IPR003599-2 |
| domain | Immunoglobulin subtype | 420 - 505 | IPR003599-3 |
| domain | Immunoglobulin subtype | 520 - 601 | IPR003599-4 |
| domain | Immunoglobulin subtype | 629 - 713 | IPR003599-5 |
| domain | Immunoglobulin subtype | 727 - 812 | IPR003599-6 |
| domain | Immunoglobulin subtype | 1104 - 1188 | IPR003599-7 |
| domain | Immunoglobulin subtype | 1244 - 1328 | IPR003599-8 |
| domain | Immunoglobulin subtype | 1815 - 1900 | IPR003599-9 |
| domain | Fibronectin type III | 1331 - 1426 | IPR003961 |
| domain | Immunoglobulin-like domain | 33 - 122 | IPR007110-1 |
| domain | Immunoglobulin-like domain | 161 - 249 | IPR007110-2 |
| domain | Immunoglobulin-like domain | 414 - 503 | IPR007110-3 |
| domain | Immunoglobulin-like domain | 514 - 599 | IPR007110-4 |
| domain | Immunoglobulin-like domain | 620 - 711 | IPR007110-5 |
| domain | Immunoglobulin-like domain | 721 - 808 | IPR007110-6 |
| domain | Immunoglobulin-like domain | 1098 - 1186 | IPR007110-7 |
| domain | Immunoglobulin-like domain | 1238 - 1326 | IPR007110-8 |
| domain | Immunoglobulin-like domain | 1809 - 1898 | IPR007110-9 |
| active_site | Serine/threonine-protein kinase, active site | 1581 - 1593 | IPR008271 |
| domain | Immunoglobulin I-set | 33 - 123 | IPR013098-1 |
| domain | Immunoglobulin I-set | 161 - 250 | IPR013098-2 |
| domain | Immunoglobulin I-set | 414 - 504 | IPR013098-3 |
| domain | Immunoglobulin I-set | 514 - 600 | IPR013098-4 |
| domain | Immunoglobulin I-set | 624 - 712 | IPR013098-5 |
| domain | Immunoglobulin I-set | 722 - 809 | IPR013098-6 |
| domain | Immunoglobulin I-set | 1098 - 1187 | IPR013098-7 |
| domain | Immunoglobulin I-set | 1238 - 1327 | IPR013098-8 |
| domain | Immunoglobulin I-set | 1809 - 1899 | IPR013098-9 |
| domain | Myosin Light Chain Kinase 1, Kinase domain | 1461 - 1719 | IPR015725 |
| binding_site | Protein kinase, ATP binding site | 1470 - 1493 | IPR017441 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell surface | The external part of the cell wall and/or plasma membrane. |
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| transmembrane-ephrin receptor activity | Combining with a transmembrane ephrin to initiate a change in cell activity. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| activated T cell proliferation | The expansion of a T cell population following activation by an antigenic stimulus. |
| axon guidance | The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. |
| ephrin receptor signaling pathway | The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| positive regulation of T cell costimulation | Any process that activates or increases the frequency, rate or extent of T cell costimulation. |
| T cell mediated immunity | Any process involved in the carrying out of an immune response by a T cell. |
| type IV hypersensitivity | An inflammatory response driven by T cell recognition of processed soluble or cell-associated antigens leading to cytokine release and leukocyte activation. |
52 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P28693 | EPHB2 | Ephrin type-B receptor 2 | Gallus gallus (Chicken) | PR |
| Q07496 | EPHA4 | Ephrin type-A receptor 4 | Gallus gallus (Chicken) | SS |
| Q07494 | EPHB1 | Ephrin type-B receptor 1 | Gallus gallus (Chicken) | SS |
| Q07497 | EPHB5 | Ephrin type-B receptor 5 | Gallus gallus (Chicken) | PR |
| P29318 | EPHA3 | Ephrin type-A receptor 3 | Gallus gallus (Chicken) | SS |
| O42422 | EPHA7 | Ephrin type-A receptor 7 | Gallus gallus (Chicken) | SS |
| P54755 | EPHA5 | Ephrin type-A receptor 5 | Gallus gallus (Chicken) | SS |
| Q07498 | EPHB3 | Ephrin type-B receptor 3 | Gallus gallus (Chicken) | SS |
| P0C0K6 | EPHB6 | Ephrin type-B receptor 6 | Pan troglodytes (Chimpanzee) | SS |
| P29322 | EPHA8 | Ephrin type-A receptor 8 | Homo sapiens (Human) | SS |
| P21709 | EPHA1 | Ephrin type-A receptor 1 | Homo sapiens (Human) | SS |
| P54764 | EPHA4 | Ephrin type-A receptor 4 | Homo sapiens (Human) | SS |
| P54753 | EPHB3 | Ephrin type-B receptor 3 | Homo sapiens (Human) | SS |
| P29320 | EPHA3 | Ephrin type-A receptor 3 | Homo sapiens (Human) | PR |
| P54760 | EPHB4 | Ephrin type-B receptor 4 | Homo sapiens (Human) | SS |
| P29317 | EPHA2 | Ephrin type-A receptor 2 | Homo sapiens (Human) | SS |
| Q15375 | EPHA7 | Ephrin type-A receptor 7 | Homo sapiens (Human) | SS |
| Q5JZY3 | EPHA10 | Ephrin type-A receptor 10 | Homo sapiens (Human) | SS |
| P29323 | EPHB2 | Ephrin type-B receptor 2 | Homo sapiens (Human) | EV |
| Q9UF33 | EPHA6 | Ephrin type-A receptor 6 | Homo sapiens (Human) | SS |
| P54762 | EPHB1 | Ephrin type-B receptor 1 | Homo sapiens (Human) | SS |
| P54756 | EPHA5 | Ephrin type-A receptor 5 | Homo sapiens (Human) | SS |
| O15197 | EPHB6 | Ephrin type-B receptor 6 | Homo sapiens (Human) | SS |
| P54754 | Ephb3 | Ephrin type-B receptor 3 | Mus musculus (Mouse) | SS |
| Q03145 | Epha2 | Ephrin type-A receptor 2 | Mus musculus (Mouse) | PR |
| Q03137 | Epha4 | Ephrin type-A receptor 4 | Mus musculus (Mouse) | SS |
| Q61772 | Epha7 | Ephrin type-A receptor 7 | Mus musculus (Mouse) | SS |
| O09127 | Epha8 | Ephrin type-A receptor 8 | Mus musculus (Mouse) | SS |
| Q8CBF3 | Ephb1 | Ephrin type-B receptor 1 | Mus musculus (Mouse) | SS |
| Q8BYG9 | Epha10 | Ephrin type-A receptor 10 | Mus musculus (Mouse) | SS |
| Q60629 | Epha5 | Ephrin type-A receptor 5 | Mus musculus (Mouse) | SS |
| P29319 | Epha3 | Ephrin type-A receptor 3 | Mus musculus (Mouse) | SS |
| Q62413 | Epha6 | Ephrin type-A receptor 6 | Mus musculus (Mouse) | SS |
| Q60750 | Epha1 | Ephrin type-A receptor 1 | Mus musculus (Mouse) | SS |
| P54763 | Ephb2 | Ephrin type-B receptor 2 | Mus musculus (Mouse) | SS |
| P54761 | Ephb4 | Ephrin type-B receptor 4 | Mus musculus (Mouse) | PR |
| O08644 | Ephb6 | Ephrin type-B receptor 6 | Mus musculus (Mouse) | PR |
| P09759 | Ephb1 | Ephrin type-B receptor 1 | Rattus norvegicus (Rat) | SS |
| P54759 | Epha7 | Ephrin type-A receptor 7 | Rattus norvegicus (Rat) | SS |
| P54757 | Epha5 | Ephrin type-A receptor 5 | Rattus norvegicus (Rat) | SS |
| O08680 | Epha3 | Ephrin type-A receptor 3 | Rattus norvegicus (Rat) | SS |
| O61460 | vab-1 | Ephrin receptor 1 | Caenorhabditis elegans | SS |
| Q9LSV3 | WAKL16 | Putative wall-associated receptor kinase-like 16 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SCZ4 | FER | Receptor-like protein kinase FERONIA | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M345 | LECRK42 | L-type lectin-domain containing receptor kinase IV.2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M342 | WAKL15 | Wall-associated receptor kinase-like 15 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8VZJ9 | CRCK2 | Calmodulin-binding receptor-like cytoplasmic kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FLW0 | At5g24010 | Probable receptor-like protein kinase At5g24010 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q3E8W4 | ANX2 | Receptor-like protein kinase ANXUR2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O13147 | ephb3 | Ephrin type-B receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| O13146 | epha3 | Ephrin type-A receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| O73878 | ephb4b | Ephrin type-B receptor 4b | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MASENTAGSG | SRVAGMVYSL | WLLVLGPSVL | ALEEVLLDTT | GETSEIGWLT | YPPGGWDEVS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VLDDQRRLTR | TFEACHVAGL | PPGSGQDNWL | QTHFVERRGA | QRAHIRLHFS | VRACSSLGVS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GGTCRETFTL | YYRQADEPDS | PDSISAWHLK | RWTKVDTIAA | DESFPASSSS | SSWAVGPHRT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DQRVGLQLNV | KERSFGPLTQ | RGFYVAFQDT | GACLALVAVK | LFSYTCPSVL | RAFASFPETQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ASGAGGASLV | AAVGTCVAHA | EPEEDGVGGQ | AGGSPPRLHC | NGEGRWMVAV | GGCRCQPGHQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PARGDKLCQA | CPEGSYKALP | GNVPCSPCPA | RSHSPDPAAP | VCPCLQGFYR | ASSDPPEAPC |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TGPPSAPREL | WFEVQGSALM | LHWRLPQELG | GRGDLLFNVV | CKECGGHKEP | SSGGMCRRCR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DEVHFDPRQR | GLTESRVLVG | GLRAHVPYIL | EVQAVNGVSE | LSPDPPQAAA | INVSTSHEVP |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SAVPVMHQVS | RAANSITVSW | PQPEQTNGNI | LDYQLRYYDQ | AEDESHSFTM | TSETNTATVT |
| 550 | 560 | 570 | 580 | 590 | 600 |
| RLSPGHIYGF | QVRARTAAGH | GPYGGKVYFQ | TLPQGELSSQ | LPEKLSLVIG | SILGALAFLL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LAAITVLAVI | FQRKRRGTGY | TEQLQQYSSP | GLGVKYYIDP | STYDDPCQAI | RELAREVDPT |
| 670 | 680 | 690 | 700 | 710 | 720 |
| YIKIEEVIGA | GSFGEVRRGR | LQPRGRREQA | VAIQALWAGG | AESLKMTFLG | RAALLGQFQH |
| 730 | 740 | 750 | 760 | 770 | 780 |
| PNILRLEGVV | TRSRPVMVLT | ELMELGPLDS | FLRQREGQFS | SLQLVAMQRG | VAAAMQYLSS |
| 790 | 800 | 810 | 820 | 830 | 840 |
| FAFVHRALSA | RSVLVNSHLV | CKVARLGHSP | QGSSSLLRWA | APEVITHGKY | TTSSDVWSFG |
| 850 | 860 | 870 | 880 | 890 | 900 |
| ILMWEVMSYG | ERPYWDMSDQ | EVLNAIEQEF | RLPPPPGCPT | GLHLLMLDTW | QKDRARRPHF |
| 910 | 920 | 930 | 940 | 950 | 960 |
| DQLVAAFDKM | IRKPDTLQAE | GSSGDRPSQA | LLNPVALDFP | CLDSPQAWLS | AIGLECYQDN |
| 970 | 980 | 990 | 1000 | 1010 | |
| FSKFGLSTFS | DVAQLSLEDL | PGLGITLAGH | QKKLLHNIQL | LQQHLRQPGS | VEV |