P0AA84

PR
Gene name
clsB
Protein name
Cardiolipin synthase B
Names
CL synthase
Species
Escherichia coli (strain K12)
KEGG Pathway
eco:b0789
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

364-413 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P0AA84

Entry ID Method Resolution Chain Position Source
AF-P0AA84-F1 Predicted AlphaFoldDB

No variants for P0AA84

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P0AA84

No associated diseases with P0AA84

4 regional properties for P0AA84

Type Name Position InterPro Accession
domain Phospholipase D/Transphosphatidylase 108 - 135 IPR001736-1
domain Phospholipase D/Transphosphatidylase 285 - 312 IPR001736-2
domain Phospholipase D-like domain 26 - 152 IPR025202-1
domain Phospholipase D-like domain 214 - 336 IPR025202-2

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
cardiolipin synthase activity Catalysis of the reaction: phosphatidylglycerol + phosphatidylglycerol = diphosphatidylglycerol (cardiolipin) + glycerol.
phospholipase D activity Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate.

1 GO annotations of biological process

Name Definition
cardiolipin biosynthetic process The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P0A6H8 clsA Cardiolipin synthase A Escherichia coli (strain K12) PR
10 20 30 40 50 60
MKCSWREGNK IQLLENGEQY YPAVFKAIGE AQERIILETF IWFEDDVGKQ LHAALLAAAQ
70 80 90 100 110 120
RGVKAEVLLD GYGSPDLSDE FVNELTAAGV VFRYYDPRPR LFGMRTNVFR RMHRKIVVID
130 140 150 160 170 180
ARIAFIGGLN YSAEHMSSYG PEAKQDYAVR LEGPIVEDIL QFELENLPGQ SAARRWWRRH
190 200 210 220 230 240
HKAEENRQPG EAQVLLVWRD NEEHRDDIER HYLKMLTQAR REVIIANAYF FPGYRFLHAL
250 260 270 280 290 300
RKAARRGVRI KLIIQGEPDM PIVRVGARLL YNYLVKGGVQ VFEYRRRPLH GKVALMDDHW
310 320 330 340 350 360
ATVGSSNLDP LSLSLNLEAN VIIHDRHFNQ TLRDNLNGII AADCQQVDET MLPKRTWWNL
370 380 390 400 410
TKSVLAFHFL RHFPALVGWL PAHTPRLAQV DPPAQPTMET QDRVETENTG VKP