P0A6H8
Gene name |
clsA |
Protein name |
Cardiolipin synthase A |
Names |
CL synthase |
Species |
Escherichia coli (strain K12) |
KEGG Pathway |
eco:b1249 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P0A6H8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P0A6H8-F1 | Predicted | AlphaFoldDB |
4 variants for P0A6H8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| 113 | I>S | strain: ECOR 60 [UniProt] | No | ||
| 283 | E>G | strain: ECOR 50 [UniProt] | No | ||
| 378 | G>S | strain: ECOR 16 [UniProt] | No | ||
| 426 | S>R | strain: ECOR 46 [UniProt] | No |
No associated diseases with P0A6H8
5 regional properties for P0A6H8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Phospholipase D/Transphosphatidylase | 219 - 246 | IPR001736-1 |
| domain | Phospholipase D/Transphosphatidylase | 399 - 426 | IPR001736-2 |
| domain | Phospholipase D-like domain | 134 - 242 | IPR025202-1 |
| domain | Phospholipase D-like domain | 331 - 445 | IPR025202-2 |
| domain | Cardiolipin synthase N-terminal | 23 - 59 | IPR027379 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| cardiolipin synthase activity | Catalysis of the reaction: phosphatidylglycerol + phosphatidylglycerol = diphosphatidylglycerol (cardiolipin) + glycerol. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| cardiolipin biosynthetic process | The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P0AA84 | clsB | Cardiolipin synthase B | Escherichia coli (strain K12) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTTVYTLVSW | LAILGYWLLI | AGVTLRILMK | RRAVPSAMAW | LLIIYILPLV | GIIAYLAVGE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LHLGKRRAER | ARAMWPSTAK | WLNDLKACKH | IFAEENSSVA | APLFKLCERR | QGIAGVKGNQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LQLMTESDDV | MQALIRDIQL | ARHNIEMVFY | IWQPGGMADQ | VAESLMAAAR | RGIHCRLMLD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SAGSVAFFRS | PWPELMRNAG | IEVVEALKVN | LMRVFLRRMD | LRQHRKMIMI | DNYIAYTGSM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NMVDPRYFKQ | DAGVGQWIDL | MARMEGPIAT | AMGIIYSCDW | EIETGKRILP | PPPDVNIMPF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EQASGHTIHT | IASGPGFPED | LIHQALLTAA | YSAREYLIMT | TPYFVPSDDL | LHAICTAAQR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GVDVSIILPR | KNDSMLVGWA | SRAFFTELLA | AGVKIYQFEG | GLLHTKSVLV | DGELSLVGTV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NLDMRSLWLN | FEITLAIDDK | GFGADLAAVQ | DDYISRSRLL | DARLWLKRPL | WQRVAERLFY |
| FFSPLL |