P0A9F9

PR
Gene name
metR (b3828, JW3804)
Protein name
HTH-type transcriptional regulator MetR
Names
Species
Escherichia coli (strain K12)
KEGG Pathway
eco:b3828
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

48-118 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for P0A9F9

Entry ID Method Resolution Chain Position Source
5FO5 X-ray 216 A A 1-92 PDB
AF-P0A9F9-F1 Predicted AlphaFoldDB

No variants for P0A9F9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P0A9F9

No associated diseases with P0A9F9

3 regional properties for P0A9F9

Type Name Position InterPro Accession
domain Transcription regulator HTH, LysR 2 - 63 IPR000847
domain LysR, substrate-binding 86 - 288 IPR005119
domain HTH-type transcriptional regulator MetR, PBP2 domain 90 - 285 IPR037406

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
amino acid binding Binding to an amino acid, organic acids containing one or more amino substituents.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-binding transcription factor activity A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
transcription cis-regulatory region binding Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.

2 GO annotations of biological process

Name Definition
methionine biosynthetic process The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
regulation of DNA-templated transcription Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P77744 abgR HTH-type transcriptional regulator AbgR Escherichia coli (strain K12) PR
10 20 30 40 50 60
MIEVKHLKTL QALRNCGSLA AAAATLHQTQ SALSHQFSDL EQRLGFRLFV RKSQPLRFTP
70 80 90 100 110 120
QGEILLQLAN QVLPQISQAL QACNEPQQTR LRIAIECHSC IQWLTPALEN FHKNWPQVEM
130 140 150 160 170 180
DFKSGVTFDP QPALQQGELD LVMTSDILPR SGLHYSPMFD YEVRLVLAPD HPLAAKTRIT
190 200 210 220 230 240
PEDLASETLL IYPVQRSRLD VWRHFLQPAG VSPSLKSVDN TLLLIQMVAA RMGIAALPHW
250 260 270 280 290 300
VVESFERQGL VVTKTLGEGL WSRLYAAVRD GEQRQPVTEA FIRSARNHAC DHLPFVKSAE
310
RPTYDAPTVR PGSPARL