P08728

PR
Gene name
KRT19
Protein name
Keratin, type I cytoskeletal 19
Names
Cytokeratin-19, CK-19, Keratin-19, K19
Species
Bos taurus (Bovine)
KEGG Pathway
bta:514812
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-54 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P08728

Entry ID Method Resolution Chain Position Source
AF-P08728-F1 Predicted AlphaFoldDB

125 variants for P08728

Variant ID(s) Position Change Description Diseaes Association Provenance
rs463474408 7 R>G No EVA
rs454396963 12 T>S No EVA
rs440778573 15 F>C No EVA
rs452267031 18 M>R No EVA
rs476179901 21 G>D No EVA
rs457282042 22 S>C No EVA
rs437210982 23 M>K No EVA
rs468693644 24 R>P No EVA
rs446336118 30 A>P No EVA
rs477616051 33 A>P No EVA
rs463913778 33 A>V No EVA
rs481217131 36 I>M No EVA
rs461033166 37 H>Q No EVA
rs440820005 40 S>* No EVA
rs458691911 45 V>M No EVA
rs438619378 46 S>* No EVA
rs476216808 49 S>P No EVA
rs456221644 50 A>T No EVA
rs475144044 59 G>A No EVA
rs436183013 59 G>S No EVA
rs466134399 60 Y>C No EVA
rs434800289 60 Y>H No EVA
rs446371312 61 G>C No EVA
rs450346902 68 L>R No EVA
rs461022654 70 T>P No EVA
rs461022654 70 T>S No EVA
rs447298614 81 L>I No EVA
rs458328870 85 N>T No EVA
rs438356203 88 D>A No EVA
rs482765043 88 D>E No EVA
rs438356203 88 D>G No EVA
rs462669631 99 A>P No EVA
rs442621908 100 L>M No EVA
rs473997597 101 E>G No EVA
rs441259715 102 E>G No EVA
rs454961334 102 E>K No EVA
rs432329364 107 L>R No EVA
rs470503127 109 V>G No EVA
rs456788890 112 R>L No EVA
rs436593743 115 Y>S No EVA
rs467951139 116 Q>* No EVA
rs447298267 116 Q>R No EVA
rs478558028 118 Q>R No EVA
rs444834132 120 P>A No EVA
rs442677552 122 P>H No EVA
rs133275350 123 A>P No EVA
rs133275350 123 A>T No EVA
rs460308748 124 R>L No EVA
rs460308748 124 R>P No EVA
rs440192882 125 D>N No EVA
rs135396001 126 Y>D No EVA
rs135396001 126 Y>H No EVA
rs446138391 126 Y>S No EVA
rs452605225 128 H>N No EVA
rs476565750 128 H>Q No EVA
rs438842722 128 H>R No EVA
rs456784314 129 Y>N No EVA
rs436643113 129 Y>S No EVA
rs454349791 130 F>Y No EVA
rs434133664 132 T>P No EVA
rs464926948 134 E>G No EVA
rs444871108 135 D>A No EVA
rs482441256 137 R>G No EVA
rs468961700 137 R>Q No EVA
rs480598901 138 D>A No EVA
rs449091396 138 D>N No EVA
rs480598901 138 D>V No EVA
rs446660056 139 Q>E No EVA
rs477967742 139 Q>R No EVA
rs432597483 146 E>V No EVA
rs470359792 147 N>S No EVA
rs450194504 149 K>N No EVA
rs481197550 151 V>A No EVA
rs467424429 155 D>E No EVA
rs876278124 156 N>K No EVA
rs447229689 157 A>T No EVA
rs458690079 160 A>P No EVA
rs438619468 161 A>V No EVA
rs876215176 166 T>P No EVA
rs454217338 169 E>D No EVA
rs471340149 191 E>G No EVA
rs455626635 203 I>L No EVA
rs435530611 204 E>A No EVA
rs466849929 204 E>D No EVA
rs477967803 207 K>E No EVA
rs465488159 209 E>A No EVA
rs445250820 212 Y>H No EVA
rs483068367 213 L>P No EVA
rs462956397 214 K>* No EVA
rs442768239 216 N>T No EVA
rs460659444 219 E>V No EVA
rs461846377 224 L>P No EVA
rs441691042 228 V>A No EVA
rs459380375 234 V>G No EVA
rs439172046 236 V>G No EVA
rs470901214 243 D>A No EVA
rs457204031 257 V>A No EVA
rs451136278 277 L>R No EVA
rs482482273 278 N>K No EVA
rs462390332 280 E>G No EVA
rs448688259 282 A>G No EVA
rs479540728 283 G>A No EVA
rs459419095 287 Q>R No EVA
rs876477089 295 V>A No EVA
rs876324706 297 D>A No EVA
rs477005051 301 T>P No EVA
rs384651701 314 S>R No EVA
rs443468509 315 M>R No EVA
rs481144971 320 E>D No EVA
rs461062435 321 G>R No EVA
rs472160577 325 E>* No EVA
rs453348316 330 F>L No EVA
rs471071289 336 Q>P No EVA
rs437179741 340 L>P No EVA
rs468885395 341 I>V No EVA
rs466324804 349 S>R No EVA
rs446192277 351 V>A No EVA
rs477184799 353 A>T No EVA
rs449696918 354 D>G No EVA
rs469841518 354 D>Y No EVA
rs448578310 355 T>I No EVA
rs461087148 362 Y>* No EVA
rs478705452 366 M>I No EVA
rs447459544 366 M>L No EVA
rs438565641 368 I>L No EVA

No associated diseases with P08728

2 regional properties for P08728

Type Name Position InterPro Accession
conserved_site Intermediate filament protein, conserved site 376 - 384 IPR018039
domain Intermediate filament, rod domain 78 - 390 IPR039008

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
apicolateral plasma membrane The apical end of the lateral plasma membrane of epithelial cells.
costamere Regular periodic sub membranous arrays of vinculin in skeletal and cardiac muscle cells, these arrays link Z-discs to the sarcolemma and are associated with links to extracellular matrix.
cytoskeleton A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
intermediate filament A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins.
sarcolemma The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.
terminal web An actin-rich cytoskeletal network located beneath the microvilli of the apical plasma membrane of polarized epithelial cells. In addition to actin filaments, the terminal web may contain actin-binding proteins, myosin motor proteins, and intermediate filaments. The terminal web can function as a contractile structure that influences the spatial distribution of microvilli as well as the development and morphogenesis of tissues containing polarized epithelial cells.
Z disc Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.

1 GO annotations of molecular function

Name Definition
structural constituent of muscle The action of a molecule that contributes to the structural integrity of a muscle fiber.

6 GO annotations of biological process

Name Definition
cell differentiation involved in embryonic placenta development The process in which a relatively unspecialized cell acquires specialized features of the embryonic placenta.
epithelial cell differentiation The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.
intermediate filament organization Control of the spatial distribution of intermediate filaments; includes organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
Notch signaling pathway The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
response to estrogen Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics.
sarcomere organization The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P19001 Krt19 Keratin, type I cytoskeletal 19 Mus musculus (Mouse) PR
Q63279 Krt19 Keratin, type I cytoskeletal 19 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MTSYSYRQSS STSSFGGMGG GSMRFGAGGA FRAPSIHGGS GGRGVSVSSA RFVSSSSGGY
70 80 90 100 110 120
GGGYGGALAT SDGLLAGNEK LTMQNLNDRL ASYLEKVRAL EEANGDLEVK IRDWYQKQGP
130 140 150 160 170 180
GPARDYSHYF KTIEDLRDQI LGATIENSKI VLQIDNARLA ADDFRTKFET EQALRMSVEA
190 200 210 220 230 240
DINGLRRVLD ELTLARTDLE MQIEGLKEEL AYLKKNHEEE MSVLKGQVGG QVSVEVDSAP
250 260 270 280 290 300
GIDLAKILSD MRSQYEVIAE KNRKDAEAWF ISQTEELNRE VAGHTEQLQI SKTEVTDLRR
310 320 330 340 350 360
TLQGLEIELQ SQLSMKAALE GTLAETEARF GAQLAQIQAL ISGIEAQLSD VRADTERQNQ
370 380 390
EYQHLMDIKT RLEQEIATYR NLLEGQDAYF NDLSLAKAL