P06907
Gene name |
Mpz (P0) |
Protein name |
Myelin protein P0 |
Names |
Myelin peripheral protein, MPP, Myelin protein zero |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:24564 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for P06907
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1NEU | X-ray | 190 A | A | 30-153 | PDB |
| AF-P06907-F1 | Predicted | AlphaFoldDB |
No variants for P06907
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P06907 | |||||
No associated diseases with P06907
6 regional properties for P06907
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Immunoglobulin subtype | 35 - 147 | IPR003599 |
| domain | Immunoglobulin-like domain | 26 - 143 | IPR007110 |
| domain | Immunoglobulin V-set domain | 34 - 146 | IPR013106 |
| domain | Myelin protein P0, C-terminal | 184 - 248 | IPR019566 |
| conserved_site | Myelin P0 protein, conserved site | 226 - 238 | IPR019738 |
| domain | Myelin P0 protein, Ig-like domain | 30 - 146 | IPR047014 |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| basolateral plasma membrane | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| lysosome | A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. |
| myelin sheath | An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| rough endoplasmic reticulum | The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| cell aggregation | The clustering together and adhesion of initially separate cells to form an aggregate. Examples include the clustering of unicellular organisms or blood cells in suspension and the condensation of mesenchymal cells during cartilage formation. |
| cell-cell adhesion via plasma-membrane adhesion molecules | The attachment of one cell to another cell via adhesion molecules that are at least partially embedded in the plasma membrane. |
| cell-cell junction maintenance | The maintenance of junctions between cells. |
| myelination | The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier. |
| negative regulation of apoptotic process | Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAPGAPSSSP | SPILAALLFS | SLVLSPTLAI | VVYTDREVYG | AVGSQVTLHC | SFWSSEWVSD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DISFTWRYQP | EGGRDAISIF | HYAKGQPYID | EVGTFKERIQ | WVGDPSWKDG | SIVIHNLDYS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DNGTFTCDVK | NPPDIVGKTS | QVTLYVFEKV | PTRYGVVLGA | VIGGILGVVL | LLLLLFYLIR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YCWLRRQAAL | QRRLSAMEKG | KFHKSSKDSS | KRGRQTPVLY | AMLDHSRSTK | AASEKKSKGL |
| GESRKDKK |