AiPD: Autoinhibited Protein Database

O95297

Gene name	MPZL1 (PZR)
Protein name	Myelin protein zero-like protein 1
Names	Protein zero-related
Species	Homo sapiens (Human)
KEGG Pathway	hsa:9019
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

168-269 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

168-269 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

4 structures for O95297

Entry ID	Method	Resolution	Chain	Position	Source
6IGO	X-ray	275 A	A/B/C/D/E/F	36-162	PDB
6IGT	X-ray	240 A	A/B/C/D	36-162	PDB
6IGW	X-ray	198 A	A	36-162	PDB
AF-O95297-F1	Predicted				AlphaFoldDB

189 variants for O95297

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1454288172 CA343454417	3	A>G		No	ClinGen TOPMed gnomAD
CA31985180 rs1046095660	5	A>D		No	ClinGen TOPMed gnomAD
CA343454438 rs1046095660	5	A>V		No	ClinGen TOPMed gnomAD
rs937713615 CA31985191	11	I>T		No	ClinGen TOPMed
rs1398559913 CA343454533	13	A>V		No	ClinGen TOPMed
CA1226693 rs368926182	14	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA31985196 rs113319606	14	P>S		No	ClinGen Ensembl
rs562954825 CA1226694	16	S>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA343454573 rs1571124983	17	R>W		No	ClinGen Ensembl
rs1263976139 CA343454631	21	W>L		No	ClinGen gnomAD
CA1226695 rs763159564	22	S>W		No	ClinGen ExAC gnomAD
CA31985204 rs928717706	25	A>T		No	ClinGen TOPMed
rs1186290504 CA343454675	25	A>V		No	ClinGen TOPMed
CA31985206 rs1042731329	26	A>V		No	ClinGen TOPMed gnomAD
CA31985209 rs998617174	30	L>P		No	ClinGen TOPMed
CA343462108 rs1265133425	33	A>T		No	ClinGen gnomAD
rs1468010788 CA343462114	34	G>R		No	ClinGen gnomAD
TCGA novel	37	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1226714 rs761725756	38	L>V		No	ClinGen ExAC TOPMed gnomAD
rs200435022 CA1226715	39	E>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	41	Y>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1226716 rs767613384	42	T>A		No	ClinGen ExAC gnomAD
CA1226717 rs752650513	42	T>M		No	ClinGen ExAC TOPMed gnomAD
CA343462176 rs1558120628	44	K>E		No	ClinGen Ensembl
TCGA novel	45	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA343462187 rs1300307683	45	E>G		No	ClinGen TOPMed gnomAD
CA1226720 rs369822857	46	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA343462199 rs1440890527	47	F>V		No	ClinGen gnomAD
rs769743210 CA1226721	47	F>Y		No	ClinGen ExAC TOPMed gnomAD
rs1294344966 CA343462230	52	T>P		No	ClinGen gnomAD
rs749981310 CA1226723	53	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA31995472 rs886963894	54	G>R		No	ClinGen Ensembl
rs757868400 CA1226724	56	L>V		No	ClinGen ExAC gnomAD
CA1226725 rs375713174	57	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA343462301 rs1214322653	59	K>R		No	ClinGen gnomAD
CA343462300 rs1214322653	59	K>T		No	ClinGen gnomAD
rs770207236 CA1226727	61	K>E		No	ClinGen ExAC gnomAD
CA343462344 rs1184886464	62	S>A		No	ClinGen gnomAD
TCGA novel	62	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1226729 rs749557484	63	T>A		No	ClinGen ExAC gnomAD
rs771012047 CA1226730	64	S>G		No	ClinGen ExAC TOPMed gnomAD
rs774611276 CA1226731	65	T>M		No	ClinGen ExAC TOPMed gnomAD
CA343462401 rs1166209474	66	T>S		No	ClinGen gnomAD
rs1427995443 CA343462410	67	G>D		No	ClinGen gnomAD
CA1226734 CA343462416 COSM75457 rs146968580	68	G>R	ovary Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD NCI-TCGA
CA1226735 rs760634409	69	L>V		No	ClinGen ExAC gnomAD
rs1381411057 CA343462438	70	T>I		No	ClinGen Ensembl
rs1571160272 CA343462433	70	T>P		No	ClinGen Ensembl
TCGA novel	73	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA343462460 rs1477829095	74	W>*		No	ClinGen TOPMed
CA343462457 rs1571160309	74	W>G		No	ClinGen Ensembl
rs1571160321 CA343462466	75	S>G		No	ClinGen Ensembl
CA343462470 rs761643652	75	S>I		No	ClinGen ExAC gnomAD
rs761643652 CA1226738	75	S>N		No	ClinGen ExAC gnomAD
COSM207634 CA1226739 rs764835005	78	P>S	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA343462498 rs1571160339	79	E>G		No	ClinGen Ensembl
rs1213700735 CA343462505	80	G>E		No	ClinGen gnomAD
rs1340155364 CA343462504	80	G>R		No	ClinGen gnomAD
CA1226741 rs757960465	81	A>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA343462509 rs1486311901	81	A>P		No	ClinGen gnomAD
rs757960465 CA31995474	81	A>V		No	ClinGen ExAC TOPMed gnomAD
rs756537406 CA1226744	82	D>G		No	ClinGen ExAC gnomAD
CA1226743 rs753205839	82	D>N		No	ClinGen ExAC gnomAD
CA1226746 rs369996563	83	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs778224369 CA1226745	83	T>S		No	ClinGen ExAC gnomAD
CA343462525 rs1271492786	84	T>I		No	ClinGen TOPMed gnomAD
rs779345094 CA1226748	86	S>L		No	ClinGen ExAC TOPMed gnomAD
CA31400600 rs201193049	88	F>S		No	ClinGen 1000Genomes gnomAD
CA1226765 rs779365685	91	S>Y		No	ClinGen ExAC gnomAD
rs1474802929 CA343078900	95	V>A		No	ClinGen gnomAD
rs368816230 CA1226767	101	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA343079040 rs1299176972	105	D>E		No	ClinGen TOPMed
rs768163586 CA31400602	106	R>K		No	ClinGen Ensembl
rs975223626 CA31400603	108	S>I		No	ClinGen TOPMed
rs1459515451 CA343079068	109	W>C		No	ClinGen gnomAD
rs919666911 CA31400604	114	D>E		No	ClinGen gnomAD
rs1191189299 CA343079099	114	D>H		No	ClinGen gnomAD
CA1226769 rs747095862	115	K>E		No	ClinGen ExAC gnomAD
rs1175065354 CA343079121	115	K>R		No	ClinGen gnomAD
rs1416975919 CA343079177	118	A>T		No	ClinGen gnomAD
COSM3802726 rs776485240 CA1226771	119	S>*	breast [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
COSM245764 rs776485240 CA31400605	119	S>L	prostate [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs748059813 CA1226772	121	N>I		No	ClinGen ExAC gnomAD
rs748059813 CA343079239	121	N>S		No	ClinGen ExAC gnomAD
CA1226773 rs769581254	122	I>L		No	ClinGen ExAC gnomAD
TCGA novel	122	I>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA343079279 rs1315841327	123	E>D		No	ClinGen TOPMed
TCGA novel	124	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA343079316 rs1441757806	125	M>T		No	ClinGen gnomAD
rs371291585 CA1226774	128	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA343079457 rs1402673525	130	N>D		No	ClinGen TOPMed
CA343079493 rs1312139720	131	G>D		No	ClinGen TOPMed
TCGA novel	131	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA31400606 rs776105420	133	Y>C		No	ClinGen Ensembl
TCGA novel	133	Y>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA343079592 rs1558123237	134	I>S		No	ClinGen Ensembl
rs1432791249 CA343079575	134	I>V		No	ClinGen TOPMed
CA890771702 rs1392021564	135	C>*		No	ClinGen TOPMed
CA1226776 rs141242973	138	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA343079718 rs1571166040	139	N>T		No	ClinGen Ensembl
CA1226777 rs773963632	142	D>H		No	ClinGen ExAC TOPMed gnomAD
rs773963632 CA343079783	142	D>N		No	ClinGen ExAC TOPMed gnomAD
CA343079805 rs1320615133	143	I>T		No	ClinGen gnomAD
CA31400608 rs938557451	143	I>V		No	ClinGen Ensembl
rs767041612 CA1226779	144	V>I		No	ClinGen ExAC gnomAD
rs761520245 CA31400609	145	V>F		No	ClinGen gnomAD
rs761520245 CA343079830	145	V>I		No	ClinGen gnomAD
rs754317947 CA1226780	146	Q>R		No	ClinGen ExAC gnomAD
CA343079936 rs1405932686	149	H>Y		No	ClinGen gnomAD
TCGA novel	150	I>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA31400612 rs367767112	155	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA gnomAD
CA1226783 rs750771385	156	E>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
TCGA novel	158	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	158	E>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	160	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA343080429 rs1161083277	161	P>L		No	ClinGen TOPMed
rs1247714436 CA343080439	162	V>M		No	ClinGen gnomAD
CA343080509 rs1363125976	164	P>L		No	ClinGen TOPMed
CA1226800 rs762252939	166	W>*		No	ClinGen ExAC gnomAD
rs1349264719 CA343080534	166	W>G		No	ClinGen gnomAD
CA31400699 rs1003882584	169	V>M		No	ClinGen Ensembl
rs1156873021 CA343080629	171	I>V		No	ClinGen TOPMed
CA1226801 rs765882268	172	V>A		No	ClinGen ExAC gnomAD
rs1484511114 CA343080676	173	T>A		No	ClinGen gnomAD
CA1226802 rs750959095	176	V>F		No	ClinGen ExAC gnomAD
CA343080798 rs1258041456	178	G>S		No	ClinGen gnomAD
rs945103042 CA31400700	180	T>I		No	ClinGen TOPMed
CA1226804 rs368992613	182	L>P		No	ClinGen ESP ExAC gnomAD
CA1226803 rs375340075	182	L>V		No	ClinGen ESP ExAC gnomAD
rs1193169059 CA343080866	183	I>M		No	ClinGen TOPMed
CA1226805 rs751734544	183	I>V		No	ClinGen ExAC
CA343080876 rs1467307736	184	S>I		No	ClinGen TOPMed
CA343080913 rs1558123622	186	I>M		No	ClinGen Ensembl
COSM75458 rs1159371671 CA343080938	188	A>G	ovary [Cosmic]	No	ClinGen cosmic curated gnomAD
CA1226807 rs781152291	189	V>I		No	ClinGen ExAC gnomAD
rs758690840 CA1226808	191	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA1226809 rs756156098	192	R>G		No	ClinGen ExAC gnomAD
CA31400702 rs903640625	192	R>I		No	ClinGen TOPMed gnomAD
rs903640625 CA343080980	192	R>K		No	ClinGen TOPMed gnomAD
CA343080991 rs1335722851	193	R>K		No	ClinGen gnomAD
rs1259440402 CA343081039	195	N>Y		No	ClinGen TOPMed
CA343081053 rs1239106525	196	S>T		No	ClinGen gnomAD
rs749210015 CA1226811	198	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs979118953 CA31400703	198	R>W		No	ClinGen TOPMed gnomAD
CA343081148 rs1484081330	199	D>V		No	ClinGen gnomAD
rs770727398 CA1226812	202	G>S		No	ClinGen ExAC gnomAD
CA1226836 rs372694435	210	S>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1173390828 CA343082551	211	P>L		No	ClinGen gnomAD
CA343082567 rs1392954718	212	V>G		No	ClinGen gnomAD
CA343082598 rs1159103166	213	K>N		No	ClinGen gnomAD
rs1199092196 CA343082611	215	A>T		No	ClinGen TOPMed
CA1226839 rs779811233	216	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs150906954 CA1226841	217	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs561407422 CA1226840	217	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1381916466 CA343082681	218	K>N		No	ClinGen gnomAD
rs776240326 CA1226843	219	S>F		No	ClinGen ExAC gnomAD
rs1271154547 CA343082713	220	P>L		No	ClinGen gnomAD
CA31400957 rs1024099233	222	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs967018264 CA31400958	222	D>V		No	ClinGen Ensembl
CA343082780 rs1489588634	225	G>S		No	ClinGen TOPMed gnomAD
CA343082792 rs1398673524	225	G>V		No	ClinGen TOPMed
rs771515678 CA1226845	227	V>L		No	ClinGen ExAC gnomAD
rs201934009 CA1226846	232	S>F		No	ClinGen 1000Genomes ExAC gnomAD
rs201934009 CA31400960	232	S>Y		No	ClinGen 1000Genomes ExAC gnomAD
CA343082952 rs1478328701	233	G>V		No	ClinGen gnomAD
CA343082969 rs1169844613	234	S>F		No	ClinGen Ensembl
rs543649457 CA1226847	234	S>P		No	ClinGen 1000Genomes ExAC gnomAD
CA343083004 CA1226849 rs775702781	235	H>Q		No	ClinGen ExAC gnomAD
CA1226848 rs767761846	235	H>R		No	ClinGen ExAC gnomAD
CA343086189 rs1311927381	237	G>S		No	ClinGen gnomAD
CA343086194 rs1211301757	237	G>V		No	ClinGen gnomAD
rs1479973142 CA343086272	240	I>T		No	ClinGen gnomAD
CA343086308 rs1176113607	241	Y>H		No	ClinGen gnomAD
CA343086307 rs1176113607	241	Y>N		No	ClinGen gnomAD
rs746420060 CA1226881	242	A>V		No	ClinGen ExAC
CA31402453 rs146099511	244	L>*		No	ClinGen ESP
rs772413635 CA1226882	244	L>F		No	ClinGen ExAC gnomAD
rs528200726 CA1226884	248	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA343086534 rs1414789609	249	G>E		No	ClinGen gnomAD
rs146869026 CA1226885	249	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA31402463 rs1013741663	250	H>Y		No	ClinGen TOPMed
rs1024755264 CA31402467	256	N>S		No	ClinGen TOPMed
rs776847529 CA1226886	257	K>Q		No	ClinGen ExAC gnomAD
rs769945676 CA1226888	259	E>D		No	ClinGen ExAC gnomAD
CA1226889 rs773113947	263	Y>N		No	ClinGen ExAC gnomAD
CA1226890 rs375874838	264	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1367220091 CA343086789	267	R>*		No	ClinGen TOPMed gnomAD
rs190661858 CA1226893	267	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	268	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA

No associated diseases with O95297

3 regional properties for O95297

Type	Name	Position	InterPro Accession
domain	Immunoglobulin subtype	43 - 155	IPR003599
domain	Immunoglobulin-like domain	36 - 146	IPR007110
domain	Immunoglobulin V-set domain	42 - 155	IPR013106

Functions

		Description
EC Number
Subcellular Localization	Membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
cell surface	The external part of the cell wall and/or plasma membrane.
focal adhesion	A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ).
integral component of plasma membrane	The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name	Definition
structural molecule activity	The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell.

2 GO annotations of biological process

Name	Definition
cell-cell signaling	Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
transmembrane receptor protein tyrosine kinase signaling pathway	The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P06907	Mpz	Myelin protein P0	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MAASAGAGAV	IAAPDSRRWL	WSVLAAALGL	LTAGVSALEV	YTPKEIFVAN	GTQGKLTCKF
70	80	90	100	110	120
KSTSTTGGLT	SVSWSFQPEG	ADTTVSFFHY	SQGQVYLGNY	PPFKDRISWA	GDLDKKDASI
130	140	150	160	170	180
NIENMQFIHN	GTYICDVKNP	PDIVVQPGHI	RLYVVEKENL	PVFPVWVVVG	IVTAVVLGLT
190	200	210	220	230	240
LLISMILAVL	YRRKNSKRDY	TGCSTSESLS	PVKQAPRKSP	SDTEGLVKSL	PSGSHQGPVI
250	260
YAQLDHSGGH	HSDKINKSES	VVYADIRKN