P06467

PR
Gene name
Hbz (Hba-x, Hbz1)
Protein name
Hemoglobin subunit zeta
Names
Alpha-like embryonic globin chain x, Hemoglobin zeta chain, Zeta-globin
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:15126
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

17-86 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P06467

Entry ID Method Resolution Chain Position Source
AF-P06467-F1 Predicted AlphaFoldDB

12 variants for P06467

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389146750 16 E>D No EVA
rs13463378 27 T>S No EVA
rs252473648 28 E>D No EVA
rs3389159369 29 T>I No EVA
rs232347116 37 Y>F No EVA
rs3389148045 52 G>E No EVA
rs3389149458 52 G>R No EVA
rs3389120669 64 M>L No EVA
rs3389149776 74 I>N No EVA
rs3389145406 89 A>G No EVA
rs3389154592 105 C>* No EVA
rs3389149823 139 E>K No EVA

No associated diseases with P06467

1 regional properties for P06467

Type Name Position InterPro Accession
domain Globin 3 - 142 IPR000971

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
haptoglobin-hemoglobin complex A protein complex formed by the stable binding of a haptoglobin to hemoglobin.
hemoglobin complex An iron-containing, oxygen carrying complex. In vertebrates it is made up of two pairs of associated globin polypeptide chains, each chain carrying a noncovalently bound heme prosthetic group.

5 GO annotations of molecular function

Name Definition
heme binding Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
iron ion binding Binding to an iron (Fe) ion.
organic acid binding Binding to an organic acid, any acidic compound containing carbon in covalent linkage.
oxygen binding Binding to oxygen (O2).
oxygen carrier activity Binding to oxygen and delivering it to an acceptor molecule or a specific location.

7 GO annotations of biological process

Name Definition
carbon dioxide transport The directed movement of carbon dioxide (CO2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
cellular oxidant detoxification Any process carried out at the cellular level that reduces or removes the toxicity superoxide radicals or hydrogen peroxide.
erythrocyte maturation A developmental process, independent of morphogenetic (shape) change, that is required for an erythrocyte to attain its fully functional state.
hydrogen peroxide catabolic process The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2).
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
oxygen transport The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
positive regulation of cell death Any process that increases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P02197 MB Myoglobin Gallus gallus (Chicken) PR
10 20 30 40 50 60
MSLMKNERAI IMSMWEKMAA QAEPIGTETL ERLFCSYPQT KTYFPHFDLH HGSQQLRAHG
70 80 90 100 110 120
FKIMTAVGDA VKSIDNLSSA LTKLSELHAY ILRVDPVNFK LLSHCLLVTM AARFPADFTP
130 140
EVHEAWDKFM SILSSILTEK YR