P06199

PR
Gene name
CHRM2
Protein name
Muscarinic acetylcholine receptor M2
Names
Species
Sus scrofa (Pig)
KEGG Pathway
ssc:397498
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

200-307 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P06199

Entry ID Method Resolution Chain Position Source
AF-P06199-F1 Predicted AlphaFoldDB

No variants for P06199

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P06199

No associated diseases with P06199

1 regional properties for P06199

Type Name Position InterPro Accession
active_site Lipase, GDSL, active site 31 - 42 IPR008265

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
  • Postsynaptic cell membrane ; Multi-pass membrane protein
  • Phosphorylation in response to agonist binding promotes receptor internalization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
anchoring junction A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
postsynaptic membrane A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.

1 GO annotations of molecular function

Name Definition
G protein-coupled acetylcholine receptor activity Combining with acetylcholine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.

2 GO annotations of biological process

Name Definition
G protein-coupled acetylcholine receptor signaling pathway A G protein-coupled receptor signaling pathway initiated by a ligand binding to an acetylcholine receptor on the surface of a target cell, and ends with regulation of a downstream cellular process, e.g. transcription.
regulation of heart contraction Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P41985 CHRM2 Muscarinic acetylcholine receptor M2 Bos taurus (Bovine) PR
P30372 CHRM2 Muscarinic acetylcholine receptor M2 Gallus gallus (Chicken) PR
P08172 CHRM2 Muscarinic acetylcholine receptor M2 Homo sapiens (Human) PR
Q9ERZ4 Chrm2 Muscarinic acetylcholine receptor M2 Mus musculus (Mouse) PR
P04761 CHRM1 Muscarinic acetylcholine receptor M1 Sus scrofa (Pig) PR
P11483 CHRM3 Muscarinic acetylcholine receptor M3 Sus scrofa (Pig) PR
Q9U7D5 gar-3 Muscarinic acetylcholine receptor gar-3 Caenorhabditis elegans PR
10 20 30 40 50 60
MNNSTNSSNS GLALTSPYKT FEVVFIVLVA GSLSLVTIIG NILVMVSIKV NRHLQTVNNY
70 80 90 100 110 120
FLFSLACADL IIGVFSMNLY TLYTVIGYWP LGPVVCDLWL ALDYVVSNAS VMNLLIISFD
130 140 150 160 170 180
RYFCVTKPLT YPVKRTTKMA GMMIAAAWVL SFILWAPAIL FWQFIVGVRT VEDGECYIQF
190 200 210 220 230 240
FSNAAVTFGT AIAAFYLPVI IMTVLYWHIS RASKSRIKKD KKEPVANQEP VSPSLVQGRI
250 260 270 280 290 300
VKPNNNNMPG SDEALEHNKI QNGKAPRDAV TENCVQGEEK ESSNDSTSVS AVASNMRDDE
310 320 330 340 350 360
ITQDENTVST SLGHSKDENS KQTCIKIVTK TQKSDSCTPA NTTVELVGSS GQNGDEKQNI
370 380 390 400 410 420
VARKIVKMTK QPAKKKPPPS REKKVTRTIL AILLAFIITW APYNVMVLIN TFCAPCIPNT
430 440 450 460
VWTIGYWLCY INSTINPACY ALCNATFKKT FKHLLMCHYK NIGATR