P02992

PR
Gene name
TUF1 (TUFM, YOR187W)
Protein name
Elongation factor Tu, mitochondrial
Names
tufM
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YOR187W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-70 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P02992

Entry ID Method Resolution Chain Position Source
AF-P02992-F1 Predicted AlphaFoldDB

3 variants for P02992

Variant ID(s) Position Change Description Diseaes Association Provenance
s15-684079 17 S>P No SGRP
s15-684106 26 V>I No SGRP
s15-684133 35 T>A No SGRP

No associated diseases with P02992

3 regional properties for P02992

Type Name Position InterPro Accession
domain Tubby, C-terminal 113 - 403 IPR000007
domain F-box domain 52 - 100 IPR001810
conserved_site Tubby, C-terminal, conserved site 333 - 346 IPR018066

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

3 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
translation elongation factor activity Functions in chain elongation during polypeptide synthesis at the ribosome.

3 GO annotations of biological process

Name Definition
mitochondrial translation The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code.
mitochondrial translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in a mitochondrion.
translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P17745 TUFA Elongation factor Tu, chloroplastic Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MSALLPRLLT RTAFKASGKL LRLSSVISRT FSQTTTSYAA AFDRSKPHVN IGTIGHVDHG
70 80 90 100 110 120
KTTLTAAITK TLAAKGGANF LDYAAIDKAP EERARGITIS TAHVEYETAK RHYSHVDCPG
130 140 150 160 170 180
HADYIKNMIT GAAQMDGAII VVAATDGQMP QTREHLLLAR QVGVQHIVVF VNKVDTIDDP
190 200 210 220 230 240
EMLELVEMEM RELLNEYGFD GDNAPIIMGS ALCALEGRQP EIGEQAIMKL LDAVDEYIPT
250 260 270 280 290 300
PERDLNKPFL MPVEDIFSIS GRGTVVTGRV ERGNLKKGEE LEIVGHNSTP LKTTVTGIEM
310 320 330 340 350 360
FRKELDSAMA GDNAGVLLRG IRRDQLKRGM VLAKPGTVKA HTKILASLYI LSKEEGGRHS
370 380 390 400 410 420
GFGENYRPQM FIRTADVTVV MRFPKEVEDH SMQVMPGDNV EMECDLIHPT PLEVGQRFNI
430
REGGRTVGTG LITRIIE