P02921
Gene name |
melB |
Protein name |
Melibiose permease |
Names |
Melibiose carrier, Melibiose transporter, Melibiose/cation symporter, Na+ (Li+)/melibiose symporter, Thiomethylgalactoside permease II |
Species |
Escherichia coli (strain K12) |
KEGG Pathway |
eco:b4120 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P02921
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P02921-F1 | Predicted | AlphaFoldDB |
No variants for P02921
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P02921 | |||||
No associated diseases with P02921
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| melibiose:cation symporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: melibiose(out) + monovalent cation(out) = melibiose(in) + monovalent cation(in). |
| melibiose:sodium symporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: melibiose(out) + Na+(out) = melibiose(in) + Na+(in). |
| methylgalactoside transmembrane transporter activity | Enables the transfer of methylgalactoside from one side of a membrane to the other. Methylgalactoside is a compound in which the H of the OH group on carbon-1 of galactose is replaced by a methyl group. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| melibiose transport | The directed movement of melibiose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Melibiose is the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose. |
| methylgalactoside transport | The directed movement of methylgalactoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Methylgalactoside is a compound in which the H of the OH group on carbon-1 of galactose is replaced by a methyl group. |
| organic substance transport | The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A4IH46 | mfsd2b | Sphingosine-1-phosphate transporter MFSD2B | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSISMTTKLS | YGFGAFGKDF | AIGIVYMYLM | YYYTDVVGLS | VGLVGTLFLV | ARIWDAINDP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IMGWIVNATR | SRWGKFKPWI | LIGTLANSVI | LFLLFSAHLF | EGTTQIVFVC | VTYILWGMTY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TIMDIPFWSL | VPTITLDKRE | REQLVPYPRF | FASLAGFVTA | GVTLPFVNYV | GGGDRGFGFQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| MFTLVLIAFF | IVSTIITLRN | VHEVFSSDNQ | PSAEGSHLTL | KAIVALIYKN | DQLSCLLGMA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LAYNVASNII | TGFAIYYFSY | VIGDADLFPY | YLSYAGAANL | VTLVFFPRLV | KSLSRRILWA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GASILPVLSC | GVLLLMALMS | YHNVVLIVIA | GILLNVGTAL | FWVLQVIMVA | DIVDYGEYKL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| HVRCESIAYS | VQTMVVKGGS | AFAAFFIAVV | LGMIGYVPNV | EQSTQALLGM | QFIMIALPTL |
| 430 | 440 | 450 | 460 | 470 | |
| FFMVTLILYF | RFYRLNGDTL | RRIQIHLLDK | YRKVPPEPVH | ADIPVGAVSD | VKA |