A4IH46
Gene name |
mfsd2b |
Protein name |
Sphingosine-1-phosphate transporter MFSD2B |
Names |
Major facilitator superfamily domain-containing protein 2B |
Species |
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
KEGG Pathway |
xtr:100124793 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A4IH46
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A4IH46-F1 | Predicted | AlphaFoldDB |
No variants for A4IH46
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A4IH46 | |||||
No associated diseases with A4IH46
No regional properties for A4IH46
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for A4IH46 | |||
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| sphingolipid transporter activity | Enables the directed movement of sphingolipids into, out of or within a cell, or between cells. Sphingolipids are a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). |
| symporter activity | Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| carbohydrate transport | The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. |
| lipid transport | The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. |
| organic substance transport | The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon. |
| positive regulation of platelet aggregation | Any process that activates or increases the frequency, rate or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules. |
| sphingosine-1-phosphate receptor signaling pathway | A G protein-coupled receptor signaling pathway initiated by sphingosine-1-phosphate binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P02921 | melB | Melibiose permease | Escherichia coli (strain K12) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAETSRELPL | STLTASTRRA | LRIRARQARE | AKLSVLSKVC | YAIGGAPNQV | SGSASAFFLQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IYLLDVALIS | PYQASLVLSL | GKTWGGITDP | IVGYCISKSK | WTRIGRLMPW | MLGCTPFLVV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SYFLLWFVPT | FETGRVLWYL | AFFSCFQALS | TAYHVPYTTL | TMFLSTDQME | RDSATAYRMT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VEVLGTLIGA | AVQGQIVASA | HTGSHCNVTN | MTGNLTADFL | YEPTEYITSA | RQVYMIAAGI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IGCLYLLCIS | VLFLGVKERD | DPYALVAGKV | IPFFKGFRET | MQFGPYLNLI | SSFLLISAAV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QIQQSNFVLF | CTHAADLQDH | FQNLVLTILI | AAVLSIPFWQ | WFLQKFGKKM | AAFGISLMIP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FSIMLVTISS | LVVAYVVAVA | SGLSIAASLL | LPWSMLPDVV | DNFRLTNPQG | KGLEAIFYSS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FVFFTKLSAG | IALGISTLSL | QFADYNTSLC | KQSYSVVLTL | KLLIGAAPAL | MIIIGLTILA |
| 490 | 500 | 510 | |||
| FYPITEDTRK | ETELALDVIR | MRTRRSTLIV | I |