P01348

PR
Gene name
RLN
Protein name
Prorelaxin
Names
Species
Sus scrofa (Pig)
KEGG Pathway
ssc:396891
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

71-151 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P01348

Entry ID Method Resolution Chain Position Source
AF-P01348-F1 Predicted AlphaFoldDB

No variants for P01348

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P01348

No associated diseases with P01348

2 regional properties for P01348

Type Name Position InterPro Accession
domain Insulin-like 31 - 182 IPR016179
conserved_site Insulin, conserved site 168 - 182 IPR022353

Functions

Description
EC Number
Subcellular Localization
  • Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

1 GO annotations of molecular function

Name Definition
hormone activity The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process.

6 GO annotations of biological process

Name Definition
blastocyst growth An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation.
flagellated sperm motility The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm.
oocyte maturation A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization.
positive regulation of acrosome reaction Any process that activates or increases the frequency, rate or extent of the acrosome reaction.
positive regulation of epithelial cell proliferation Any process that activates or increases the rate or extent of epithelial cell proliferation.
positive regulation of glucose import Any process that activates or increases the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P01347 Rln1 Prorelaxin 1 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MPRLFSYLLG VWLLLSQLPR EIPGQSTNDF IKACGRELVR LWVEICGSVS WGRTALSLEE
70 80 90 100 110 120
PQLETGPPAE TMPSSITKDA EILKMMLEFV PNLPQELKAT LSERQPSLRE LQQSASKDSN
130 140 150 160 170 180
LNFEEFKKII LNRQNEAEDK SLLELKNLGL DKHSRKKRLF RMTLSEKCCQ VGCIRKDIAR
LC