AiPD: Autoinhibited Protein Database

O95905

Gene name	ECD
Protein name	Protein ecdysoneless homolog
Names	Human suppressor of GCR two, hSGT1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:11319
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

471-542 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

471-542 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for O95905

Entry ID	Method	Resolution	Chain	Position	Source
AF-O95905-F1	Predicted				AlphaFoldDB

499 variants for O95905

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs776894881 CA5552778	3	E>D		No	ClinGen ExAC gnomAD
CA5552777 rs575263484	4	T>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs761027313 CA5552776	5	M>V		No	ClinGen ExAC gnomAD
rs146593359 CA5552774	9	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA5552772 rs34275727	9	T>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5552773 rs34275727	9	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA377188297 rs1164457280	13	T>A		No	ClinGen gnomAD
rs1040963443 CA209594698	14	V>L		No	ClinGen TOPMed
CA377188285 rs1182566105	15	E>*		No	ClinGen gnomAD
CA5552769 rs747934699	16	Y>C		No	ClinGen ExAC gnomAD
CA5552767 rs188586367	17	C>R		No	ClinGen 1000Genomes ExAC gnomAD
CA209594685 rs929561547	21	I>L		No	ClinGen Ensembl
rs779531702 CA5552765	21	I>M		No	ClinGen ExAC gnomAD
rs757869937 CA5552764	22	P>Q		No	ClinGen ExAC gnomAD
CA377188231 rs1174214823	23	D>E		No	ClinGen gnomAD
CA377188218 rs1312782247	25	S>L		No	ClinGen gnomAD
rs774499265 CA209594673	26	R>G		No	ClinGen Ensembl
CA5552763 rs553296711	27	D>A		No	ClinGen 1000Genomes ExAC gnomAD
CA377188207 rs1222736700	27	D>Y		No	ClinGen gnomAD
CA5552761 rs757730379	31	H>R		No	ClinGen ExAC gnomAD
rs1265414899 CA377188178	31	H>Y		No	ClinGen TOPMed gnomAD
rs1325694501 CA377188163	33	E>G		No	ClinGen gnomAD
rs754234290 CA377188165	33	E>K		No	ClinGen ExAC TOPMed gnomAD
CA5552760 rs754234290	33	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA209594628 rs146885350	35	L>V		No	ClinGen ESP TOPMed
CA209594624 rs918149383	36	Q>R		No	ClinGen Ensembl
CA377188123 rs775910776	39	I>L		No	ClinGen ExAC gnomAD
CA5552756 rs143567114	39	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA5552757 rs775910776	39	I>V		No	ClinGen ExAC gnomAD
TCGA novel	40	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs534986528 CA209594598	40	E>K		No	ClinGen 1000Genomes TOPMed gnomAD
CA377188108 rs1180417497	41	R>K		No	ClinGen gnomAD
rs1234801117 CA377188093	43	I>T		No	ClinGen gnomAD
CA377188089 rs1440313828	44	T>A		No	ClinGen gnomAD
rs1244143625 CA377188086	44	T>S		No	ClinGen TOPMed
rs3812619 VAR_051970 CA5552754	45	R>Q		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA5552755 rs111606598	45	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs748081084 CA5552752	49	M>V		No	ClinGen ExAC gnomAD
TCGA novel	51	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA209594579 rs1047692688	52	P>L		No	ClinGen TOPMed gnomAD
CA377188040 rs1251394681	52	P>S		No	ClinGen TOPMed
CA209594574 rs776376702	54	I>L		No	ClinGen ExAC TOPMed gnomAD
CA5552751 rs776376702	54	I>V		No	ClinGen ExAC TOPMed gnomAD
rs768502855 CA5552750	57	N>K		No	ClinGen ExAC gnomAD
rs746823344 CA377187991	59	P>A		No	ClinGen ExAC TOPMed gnomAD
rs746823344 CA5552749	59	P>S		No	ClinGen ExAC TOPMed gnomAD
CA5552748 rs779617442	61	N>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs368849857 CA377187960	63	K>N		No	ClinGen ESP TOPMed gnomAD
rs920649752 CA209594550	64	Y>C		No	ClinGen TOPMed
CA5552746 rs748126351	66	P>*		No	ClinGen ExAC gnomAD
CA377187938 rs1353591394	66	P>L		No	ClinGen TOPMed
CA5552745 rs183966081	67	G>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs199657729 CA5552744	69	G>R		No	ClinGen ExAC TOPMed gnomAD
CA377187902 rs1476608157	70	G>V		No	ClinGen gnomAD
TCGA novel	73	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1193674546 CA377187881	74	H>Y		No	ClinGen gnomAD
CA5552722 rs150022527	78	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs150022527 COSM920254 CA5552723	78	V>M	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs374987103 CA5552721	80	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	80	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5552720 rs139306977	82	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs751792179 CA5552719	83	D>N		No	ClinGen ExAC TOPMed gnomAD
rs766465445 CA5552718	85	I>F		No	ClinGen ExAC gnomAD
CA5552717 rs762957194	85	I>M		No	ClinGen ExAC
rs1431878411 CA377187804	85	I>T		No	ClinGen TOPMed
rs766465445 CA377187806	85	I>V		No	ClinGen ExAC gnomAD
rs1175521459 CA377187802	86	E>K		No	ClinGen gnomAD
rs1280348759 CA377187784	88	E>*		No	ClinGen TOPMed gnomAD
CA5552716 rs549500447	88	E>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs549500447 CA5552715	88	E>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1280348759 CA377187786	88	E>K		No	ClinGen TOPMed gnomAD
TCGA novel	89	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA377187767 rs1332314207	90	F>C		No	ClinGen gnomAD
CA5552714 rs371506578	90	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1404860135 CA377187747	93	Y>C		No	ClinGen Ensembl
CA377187751 rs1397691009	93	Y>N		No	ClinGen gnomAD
CA377187743 COSM84016 rs1160056261	94	V>I	pancreas [Cosmic]	No	ClinGen cosmic curated TOPMed
rs771829736 CA5552712	95	I>T		No	ClinGen ExAC gnomAD
rs769978020 CA209593141	95	I>V		No	ClinGen Ensembl
COSM920253 CA5552710 rs773819452	103	P>L	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA377187671 rs1170936092	104	E>A		No	ClinGen gnomAD
rs1425257492 CA377187674	104	E>K		No	ClinGen gnomAD
CA377187652 rs1474714955	107	A>P		No	ClinGen gnomAD
rs1589121844 CA377187644	108	R>K		No	ClinGen Ensembl
rs1444549171 CA377187625	109	I>F		No	ClinGen gnomAD
rs1316997294 CA377187622	109	I>T		No	ClinGen gnomAD
rs138942541 CA5552696	111	D>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1226238109 CA377187601	112	N>S		No	ClinGen TOPMed gnomAD
rs756041378 CA5552695	114	G>V		No	ClinGen ExAC TOPMed gnomAD
rs752634743 CA5552694	115	E>G		No	ClinGen ExAC gnomAD
CA377187571 rs767505500	116	F>L		No	ClinGen ExAC gnomAD
rs866084814 CA209591988	117	L>F		No	ClinGen Ensembl
rs759189038 CA5552691	119	I>M		No	ClinGen ExAC TOPMed gnomAD
rs774231556 CA5552690	121	A>G		No	ClinGen ExAC gnomAD
rs1240386078 CA377187533	122	A>G		No	ClinGen gnomAD
rs766079576 CA5552689	122	A>S		No	ClinGen ExAC gnomAD
rs766079576 CA377187537	122	A>T		No	ClinGen ExAC gnomAD
CA5552686 rs769492013	126	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA5552685 rs371218919	127	K>E		No	ClinGen ESP ExAC gnomAD
CA5552684 rs776943705	129	L>P		No	ClinGen ExAC gnomAD
CA377187480 rs1260288847	130	D>V		No	ClinGen gnomAD
rs769239602 CA5552683	131	P>L		No	ClinGen ExAC gnomAD
rs747290156 CA5552682	132	E>G		No	ClinGen ExAC
rs866299721 CA209591976	134	S>G		No	ClinGen Ensembl
CA377187437 rs1309656033	136	N>K		No	ClinGen gnomAD
CA377187440 rs1379091633	136	N>S		No	ClinGen gnomAD
CA377187416 rs1295768734	138	V>I		No	ClinGen gnomAD
TCGA novel	140	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5552664 rs567687425	142	H>R		No	ClinGen 1000Genomes ExAC gnomAD
rs1299329280 CA377187380	143	G>R		No	ClinGen gnomAD
rs1044656324 CA209591948	146	C>*		No	ClinGen TOPMed
CA377187355 rs1423468225	146	C>Y		No	ClinGen gnomAD
CA209591943 rs1035301762	150	A>T		No	ClinGen Ensembl
CA377187327 rs1274713136	151	P>S		No	ClinGen TOPMed
CA5552659 rs147438502	154	S>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs141141485 CA209591938	157	E>Q		No	ClinGen ESP TOPMed gnomAD
rs754839251 CA5552656	159	W>*		No	ClinGen ExAC gnomAD
CA5552657 rs777956764	159	W>*		No	ClinGen ExAC gnomAD
rs751610383 CA5552655	161	P>R		No	ClinGen ExAC gnomAD
rs779978226 CA5552654	162	T>N		No	ClinGen ExAC gnomAD
CA5552653 rs373650322	163	T>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1220150606 CA377187238	165	P>R		No	ClinGen gnomAD
rs1326692342 CA377187234	166	T>A		No	ClinGen TOPMed
CA377187224 rs1207672110	167	I>S		No	ClinGen TOPMed
CA377187215 rs1340593798	169	Q>E		No	ClinGen gnomAD
TCGA novel	169	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA377187203 rs1301797477	170	A>V		No	ClinGen gnomAD
rs750245964 CA5552651	171	L>*		No	ClinGen ExAC gnomAD
CA5552650 rs764936819	171	L>F		No	ClinGen ExAC gnomAD
CA209591926 rs750245964	171	L>W		No	ClinGen ExAC gnomAD
rs373804811 CA5552649	172	N>D		No	ClinGen ESP ExAC gnomAD
TCGA novel	172	N>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1253421590 CA377187195	172	N>S		No	ClinGen TOPMed
CA5552648 rs563682731	173	I>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA377187190 rs1415412404	173	I>V		No	ClinGen gnomAD
CA5552646 rs761073742	175	T>I		No	ClinGen ExAC gnomAD
TCGA novel	176	A>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1246120883 CA377187172	176	A>T		No	ClinGen TOPMed
rs1424395206 CA377187163	177	H>R		No	ClinGen gnomAD
rs1181372011 CA377187152	179	E>K		No	ClinGen gnomAD
TCGA novel	179	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	180	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5552645 rs775919239	181	I>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs772574196 CA5552643	184	S>L		No	ClinGen ExAC gnomAD
rs148204269 CA5552642	187	I>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs771034766 CA5552640	188	R>*		No	ClinGen ExAC TOPMed gnomAD
CA5552639 rs749563650	188	R>Q		No	ClinGen ExAC gnomAD
CA5552638 rs769970350	189	A>G		No	ClinGen ExAC gnomAD
rs769970350 CA5552637	189	A>V		No	ClinGen ExAC gnomAD
CA5552636 rs370474802	190	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1377540847 CA377187082	191	V>M		No	ClinGen gnomAD
rs34251877 CA5552633	192	N>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs34251877 CA377187076	192	N>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5552634 rs34251877	192	N>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5552632 rs746192250	194	R>C		No	ClinGen ExAC TOPMed gnomAD
rs149473721 CA5552631	194	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs746192250 CA377187063	194	R>S		No	ClinGen ExAC TOPMed gnomAD
CA5552630 rs753588697	195	I>L		No	ClinGen ExAC gnomAD
CA377187056 rs1311685928	195	I>T		No	ClinGen gnomAD
rs377467640 CA5552629	197	G>A		No	ClinGen ESP ExAC gnomAD
rs766809987 CA5552603	199	P>S		No	ClinGen ExAC gnomAD
CA377187013 rs1489284479	200	E>G		No	ClinGen gnomAD
CA377187016 rs1189099383	200	E>Q		No	ClinGen gnomAD
rs369569544 CA5552602	201	K>Q		No	ClinGen ESP ExAC gnomAD
TCGA novel	202	I>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs137944633 CA5552601	204	A>G		No	ClinGen ESP ExAC gnomAD
rs1451948944 CA377186985	204	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1246711495 CA377186976	206	L>F		No	ClinGen gnomAD
rs1481496333 CA377186971	206	L>R		No	ClinGen TOPMed
CA377186966 rs1284519913	207	H>R		No	ClinGen TOPMed gnomAD
CA209591446 rs1003977371	208	R>*		No	ClinGen TOPMed gnomAD
rs1003977371 CA209591448	208	R>G		No	ClinGen TOPMed gnomAD
CA377186961 rs776043538	208	R>P		No	ClinGen ExAC gnomAD
CA5552600 rs776043538	208	R>Q		No	ClinGen ExAC gnomAD
rs1301063460 CA377186950	210	H>R		No	ClinGen gnomAD
rs776848178 CA5552598	211	C>G		No	ClinGen ExAC TOPMed gnomAD
CA5552599 rs776848178	211	C>R		No	ClinGen ExAC TOPMed gnomAD
rs1370029281 CA377186945	211	C>Y		No	ClinGen gnomAD
CA377186939 rs1303798043	212	F>L		No	ClinGen gnomAD
rs1399485010 CA377186925	214	P>A		No	ClinGen TOPMed gnomAD
TCGA novel	214	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1358485991 CA377186921	214	P>L		No	ClinGen TOPMed gnomAD
rs1399485010 CA377186924	214	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1299950021 CA377186915	215	A>D		No	ClinGen TOPMed gnomAD
CA5552596 rs747098597	216	G>D		No	ClinGen ExAC gnomAD
rs768915608 CA5552597	216	G>S		No	ClinGen ExAC TOPMed gnomAD
CA5552595 rs774282516	219	A>T		No	ClinGen ExAC gnomAD
rs770808011 CA5552594	220	V>L		No	ClinGen ExAC gnomAD
rs755730085 CA5552591 COSM239669	224	R>C	prostate [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA5552590 rs145768355	224	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs145768355 CA377186863	224	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1255722327 CA377186847	227	L>S		No	ClinGen gnomAD
CA377186840 rs1211288138	228	V>L		No	ClinGen TOPMed gnomAD
CA377186830 rs1222988988	230	A>T		No	ClinGen TOPMed
CA5552586 rs766868048	230	A>V		No	ClinGen ExAC TOPMed gnomAD
CA5552584 rs750770644	233	Q>K		No	ClinGen ExAC TOPMed gnomAD
rs1338517213 CA377186790	236	Y>D		No	ClinGen gnomAD
CA377186781 rs1264681515	237	L>P		No	ClinGen gnomAD
CA209591423 rs1054784875	238	R>*		No	ClinGen TOPMed gnomAD
COSM1348978 CA377186778 rs1401443446	238	R>Q	large_intestine Variant assessed as Somatic; 4.621e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA5552581 rs754056598	239	D>E		No	ClinGen ExAC gnomAD
rs762114627 CA5552582	239	D>V		No	ClinGen ExAC TOPMed gnomAD
rs764419959 CA5552580	241	I>V		No	ClinGen ExAC TOPMed gnomAD
CA377186757 rs1169509513	242	D>N		No	ClinGen gnomAD
rs371770780 CA5552577	244	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs369205711 CA5552576	244	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs898211801 CA209591416	245	A>T		No	ClinGen TOPMed
CA5552574 rs769632241	247	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA377186726 rs1484436546	247	R>H		No	ClinGen gnomAD
CA5552573 rs747945856	251	T>S		No	ClinGen ExAC gnomAD
CA209591407 rs763231603	252	F>*		No	ClinGen Ensembl
CA377186680 rs1260028595	254	P>T		No	ClinGen gnomAD
CA5552570 rs746477497	256	T>A		No	ClinGen ExAC gnomAD
rs367613143 CA5552569	257	R>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA377186662 rs367613143	257	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs758941381 CA5552568	257	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA5552565 rs199525944	261	S>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5552566 rs199525944	261	S>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA377186614 rs1398052680	263	T>A		No	ClinGen TOPMed
CA377186599 rs1385939812	265	T>S		No	ClinGen gnomAD
rs201647688 CA5552545	269	Y>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1427059797 CA377186567	270	A>T		No	ClinGen gnomAD
rs567996573 CA209590956	271	Q>E		No	ClinGen gnomAD
CA377186550 rs1283874590	272	L>W		No	ClinGen TOPMed
rs113384057 CA5552543	274	Q>E		No	ClinGen ExAC TOPMed gnomAD
CA5552542 rs752916755	275	Q>*		No	ClinGen ExAC TOPMed gnomAD
rs1317858089 CA377186532	275	Q>R		No	ClinGen TOPMed
rs1451297944 CA377186521	276	R>S		No	ClinGen gnomAD
CA209590947 rs868330452	279	P>S		No	ClinGen Ensembl
CA377186497 rs1265296618	280	D>G		No	ClinGen gnomAD
VAR_012191 CA5552539 rs151023501	281	R>G		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA5552538 rs375640759	281	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs151023501 CA5552540	281	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs549728029 CA5552536	282	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA377186491 rs1355581600	282	R>W		No	ClinGen TOPMed gnomAD
rs763855931 CA5552535	285	Y>C		No	ClinGen ExAC gnomAD
rs1324912739 CA377186460	286	R>S		No	ClinGen gnomAD
CA5552534 rs760533724	287	L>Q		No	ClinGen ExAC gnomAD
rs1298117299 CA377186448	289	P>A		No	ClinGen gnomAD
rs1564664337 CA377186438	290	P>L		No	ClinGen Ensembl
CA5552533 rs370778375	291	S>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA377186432 rs1564664328	292	D>N		No	ClinGen Ensembl
rs1477799365 CA377186416	294	Q>*		No	ClinGen gnomAD
CA377186412 rs1201614516	294	Q>H		No	ClinGen TOPMed gnomAD
CA5552531 rs182963575	294	Q>R		No	ClinGen 1000Genomes ExAC gnomAD
rs1480798069 CA377186407	295	Y>C		No	ClinGen gnomAD
COSM1675338 CA377186402 COSM1675339 rs1348459999	296	R>*	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs765994939 CA5552530	296	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs142804992 CA5552529	298	H>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5552528 rs749880160	301	G>D		No	ClinGen ExAC gnomAD
CA377186356 rs1199698657	303	K>E		No	ClinGen gnomAD
CA5552527 rs778267726	303	K>N		No	ClinGen ExAC gnomAD
CA377186328 rs1371912972	305	A>G		No	ClinGen TOPMed
CA377186324 rs1448029637	306	H>Y		No	ClinGen gnomAD
CA377186304 rs1589116510	309	E>Q		No	ClinGen Ensembl
CA377186290 rs1589116508	310	I>M		No	ClinGen Ensembl
rs1381001036 CA377186286	311	L>S		No	ClinGen gnomAD
rs1221307331 CA377186289	311	L>V		No	ClinGen TOPMed
CA5552507 rs770360802	312	C>S		No	ClinGen ExAC gnomAD
rs1399883746 CA377186270	313	S>F		No	ClinGen gnomAD
CA377186274 rs1299714080	313	S>P		No	ClinGen TOPMed
CA377186260 rs1411713427	315	C>R		No	ClinGen gnomAD
rs1311969597 CA377186235	318	H>R		No	ClinGen TOPMed
CA5552504 rs781657306	321	D>E		No	ClinGen ExAC gnomAD
CA5552503 rs755122185	322	C>Y		No	ClinGen ExAC TOPMed gnomAD
rs1589116479 CA377186200	323	K>R		No	ClinGen Ensembl
rs1184004942 CA377186179	326	L>F		No	ClinGen gnomAD
CA5552501 rs139937454	329	A>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA5552500 rs139937454	329	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1564663074 CA377186148	331	P>L		No	ClinGen Ensembl
rs1206252542 CA377186139	333	W>R		No	ClinGen gnomAD
CA377186100 rs1288578953	338	E>G		No	ClinGen gnomAD
rs1247049767 CA377186095	339	S>G		No	ClinGen TOPMed
CA5552498 rs777523832	340	L>P		No	ClinGen ExAC TOPMed gnomAD
rs756130136 CA5552497	344	D>E		No	ClinGen ExAC gnomAD
rs1357958927 CA377186060	344	D>Y		No	ClinGen gnomAD
TCGA novel	347	K>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA209584839 rs200481547	348	G>R		No	ClinGen TOPMed gnomAD
rs76434138 CA209584836	348	G>V		No	ClinGen Ensembl
rs1343200305 CA377186012	349	L>Q		No	ClinGen gnomAD
CA5552473 rs545988421	350	I>L		No	ClinGen 1000Genomes ExAC gnomAD
CA5552472 rs545988421	350	I>V		No	ClinGen 1000Genomes ExAC gnomAD
CA377185998 rs1367239004	351	E>D		No	ClinGen TOPMed
CA377186004 rs1163457596	351	E>K		No	ClinGen TOPMed
CA5552471 rs376310717	352	G>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs766077361 CA377185981	354	A>G		No	ClinGen ExAC gnomAD
rs766077361 CA5552470	354	A>V		No	ClinGen ExAC gnomAD
rs762743509 CA5552469	355	Q>H		No	ClinGen ExAC gnomAD
CA377185977 rs1015700289	355	Q>L		No	ClinGen TOPMed
CA209584824 rs1015700289	355	Q>R		No	ClinGen TOPMed
rs147908494 CA5552467	357	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs749869606 CA5552468	357	R>W		No	ClinGen ExAC TOPMed gnomAD
CA5552466 rs762212156	360	L>Q		No	ClinGen ExAC TOPMed gnomAD
CA5552464 rs769183931	364	E>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA5552463 rs373086705	365	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	369	L>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA377185869 rs1382699490	371	V>I		No	ClinGen gnomAD
CA5552459 rs145211991	374	P>T		No	ClinGen ESP ExAC gnomAD
rs139699926 CA5552458	376	S>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs763664480 CA5552425	377	S>F		No	ClinGen ExAC gnomAD
rs763664480 CA5552426	377	S>Y		No	ClinGen ExAC gnomAD
CA377185577 rs1308335631	378	L>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs756603743 CA5552424	379	A>V		No	ClinGen ExAC gnomAD
CA209582765 rs889426343	381	S>R		No	ClinGen TOPMed
CA377185548 rs1381841364	382	P>S		No	ClinGen gnomAD
CA5552421 rs768020117	383	G>D		No	ClinGen ExAC TOPMed gnomAD
rs148267944 CA5552420	385	E>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5552419 rs774599264	388	T>I		No	ClinGen ExAC TOPMed gnomAD
CA377185499 rs149336255	389	L>F		No	ClinGen ESP ExAC gnomAD
rs369177164 CA5552417	391	Q>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA377185478 rs1352553966	393	I>L		No	ClinGen TOPMed
rs773420599 CA5552415	393	I>R		No	ClinGen ExAC TOPMed gnomAD
rs748249410 CA5552414	395	F>S		No	ClinGen ExAC gnomAD
rs748249410 CA5552413	395	F>Y		No	ClinGen ExAC gnomAD
CA5552412 rs775500009	396	D>E		No	ClinGen ExAC gnomAD
CA377185450 rs745653828	397	I>R		No	ClinGen ExAC TOPMed gnomAD
CA5552410 rs745653828	397	I>T		No	ClinGen ExAC TOPMed gnomAD
rs567071975 CA5552411	397	I>V		No	ClinGen 1000Genomes ExAC gnomAD
rs778614213 CA5552409	398	E>G		No	ClinGen ExAC gnomAD
rs7083532 CA209582735	399	D>N		No	ClinGen Ensembl
TCGA novel	400	L>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs374769397 CA209582733	400	L>R		No	ClinGen ESP TOPMed gnomAD
CA377185425 rs1266948626	401	K>R		No	ClinGen gnomAD
CA377185420 rs1564660055	402	K>Q		No	ClinGen Ensembl
CA5552408 rs770616157	403	E>Q		No	ClinGen ExAC gnomAD
CA377185402 rs1490496881	404	A>G		No	ClinGen gnomAD
rs777418264 CA5552406	406	N>I		No	ClinGen ExAC gnomAD
rs777418264 CA377185391	406	N>S		No	ClinGen ExAC gnomAD
rs1352329174 CA377185376	408	P>L		No	ClinGen gnomAD
CA377185373 rs1232126927	409	P>L		No	ClinGen gnomAD
rs755558331 CA5552405	409	P>S		No	ClinGen ExAC TOPMed gnomAD
rs7083418 CA5552404	410	E>K		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	410	E>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5552403 rs781685876	412	D>N		No	ClinGen ExAC gnomAD
CA5552383 rs747630787	415	W>*		No	ClinGen ExAC TOPMed gnomAD
CA377185320 rs1418942224	415	W>G		No	ClinGen TOPMed gnomAD
CA377185316 rs1428088255	415	W>L		No	ClinGen TOPMed
rs150500888 CA5552381	419	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs141641524 CA209582635	421	D>E		No	ClinGen ESP
COSM1505716 rs200978167 CA5552380	423	L>P	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA377185260 rs1589679619	424	D>A		No	ClinGen Ensembl
rs780621697 CA5552379	424	D>N		No	ClinGen ExAC gnomAD
rs758769408 CA5552378	425	Q>*		No	ClinGen ExAC gnomAD
rs1203953814 CA377185233	428	Q>P		No	ClinGen gnomAD
TCGA novel	429	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1436719999 CA377185230	429	E>K		No	ClinGen gnomAD
CA377185225 rs1270345965	429	E>V		No	ClinGen TOPMed gnomAD
CA5552375 rs762168022	430	A>T		No	ClinGen ExAC gnomAD
rs753949042 CA5552374	431	V>A		No	ClinGen ExAC TOPMed gnomAD
CA377185215 rs1342093709	431	V>F		No	ClinGen TOPMed gnomAD
CA377185217 rs1342093709	431	V>I		No	ClinGen TOPMed gnomAD
CA377185205 rs1245726453	433	K>E		No	ClinGen gnomAD
rs1245726453 CA377185206	433	K>Q		No	ClinGen gnomAD
CA5552373 rs764140915	433	K>R		No	ClinGen ExAC gnomAD
CA209582617 rs1007524995	434	K>N		No	ClinGen TOPMed
CA5552372 rs773708177	436	S>P		No	ClinGen ExAC TOPMed gnomAD
CA5552370 rs770936832	437	E>K		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	438	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1420172613 CA377185131	443	E>D		No	ClinGen TOPMed gnomAD
CA5552367 rs574287013	444	K>E		No	ClinGen 1000Genomes ExAC gnomAD
rs776189860 CA5552365	445	E>D		No	ClinGen ExAC gnomAD
CA5552366 rs747860932	445	E>K		No	ClinGen ExAC gnomAD
CA377185113 rs1253956082	446	Q>R		No	ClinGen TOPMed
rs746532921 CA5552363	448	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs1230608557 CA377185101	448	Y>N		No	ClinGen gnomAD
rs1275944269 CA377185074	451	T>I		No	ClinGen gnomAD
rs1440012354 CA377185077	451	T>S		No	ClinGen gnomAD
rs3736518 VAR_051971 CA5552362	452	E>Q		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1036705005 CA209582589	455	E>Q		No	ClinGen TOPMed
CA377185036 rs1372874560	457	M>T		No	ClinGen TOPMed gnomAD
rs759024075 CA5552360	457	M>V		No	ClinGen ExAC gnomAD
rs779489054 CA5552358	463	K>*		No	ClinGen ExAC gnomAD
CA377184968 rs1302469047	467	H>L		No	ClinGen gnomAD
CA209582575 rs958559470	472	L>V		No	ClinGen Ensembl
rs143345132 CA5552356	474	R>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA5552355 rs143345132	474	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs34313575 CA5552344	475	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA377184898 rs1197759352	476	P>L		No	ClinGen TOPMed
CA377184903 rs1452754466	476	P>T		No	ClinGen gnomAD
rs1343256675 CA377184892	477	S>F		No	ClinGen gnomAD
CA377184885 rs2271905	478	E>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs772702159 CA5552342	479	A>S		No	ClinGen ExAC TOPMed gnomAD
CA209582191 rs901358755	481	I>T		No	ClinGen TOPMed
rs779579226 CA5552340	481	I>V		No	ClinGen ExAC gnomAD
rs1406417402 CA377184848	484	D>V		No	ClinGen TOPMed
rs368272944 CA5552339	485	A>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA5552337 rs777812308	487	S>F		No	ClinGen ExAC gnomAD
TCGA novel	488	F>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5552336 rs202192150	489	L>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5552335 rs202192150	489	L>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs767647886 CA5552334	490	N>D		No	ClinGen ExAC gnomAD
CA5552333 rs370369866	491	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	492	F>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1262544427 CA377184790	493	D>A		No	ClinGen gnomAD
rs1221790693 CA377184782	494	K>T		No	ClinGen gnomAD
rs1325811464 CA377184777	495	I>L		No	ClinGen gnomAD
rs750300891 CA5552332	497	G>R		No	ClinGen ExAC
CA377184729 rs1397949331	500	P>R		No	ClinGen TOPMed
rs997158735 CA209581798	501	N>D		No	ClinGen Ensembl
CA377184725 rs36152134	501	N>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5552310 VAR_051972 rs36152134	501	N>S		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs36152134 CA377184726	501	N>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5552308 rs147899211	504	D>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs778773256 CA5552307	511	E>G		No	ClinGen ExAC gnomAD
rs535058684 CA5552306	512	D>E		No	ClinGen 1000Genomes ExAC gnomAD
rs887598631 CA209581780	514	E>D		No	ClinGen TOPMed gnomAD
CA5552305 rs753571418	514	E>K		No	ClinGen ExAC gnomAD
CA377184609 rs1479588099	517	D>E		No	ClinGen TOPMed gnomAD
CA377184615 rs1446159511	517	D>N		No	ClinGen TOPMed
CA209581776 rs574386748	518	S>G		No	ClinGen 1000Genomes
CA377184587 rs1205871283	520	D>A		No	ClinGen gnomAD
CA5552302 rs148424337	521	D>Y		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5552301 rs767311213	522	L>W		No	ClinGen ExAC TOPMed gnomAD
CA377184554 rs1340729842	525	E>Q		No	ClinGen gnomAD
rs144762181 CA5552298	530	G>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM414966 CA5552296 rs763580316	531	E>K	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA377184514 rs763580316	531	E>Q		No	ClinGen ExAC gnomAD
CA377184497 rs1462244327	533	A>S		No	ClinGen TOPMed
rs1057443269 CA209581756	533	A>V		No	ClinGen Ensembl
rs773433177 CA5552295	537	G>A		No	ClinGen ExAC gnomAD
rs938655879 CA209581753	537	G>R		No	ClinGen Ensembl
CA5552294 rs770135861	539	L>F		No	ClinGen ExAC gnomAD
CA5552293 rs748515708	539	L>R		No	ClinGen ExAC gnomAD
rs149666428 CA5552292	540	D>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA377184450 rs1181416956	541	N>S		No	ClinGen gnomAD
TCGA novel	541	N>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1169360677 CA377184444	542	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs142175521 CA5552291	544	S>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5552290 rs747068425	546	M>V		No	ClinGen ExAC gnomAD
CA5552289 rs377268652	548	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA5552288 rs757129776	549	M>L		No	ClinGen ExAC gnomAD
rs914765225 CA209581727	550	D>A		No	ClinGen Ensembl
CA377184388 rs1589677508	550	D>H		No	ClinGen Ensembl
rs200561293 CA5552287	554	A>V		No	ClinGen 1000Genomes ExAC
rs1289274506 CA377184356	555	H>N		No	ClinGen gnomAD
rs1289274506 CA377184355	555	H>Y		No	ClinGen gnomAD
rs777578873 CA5552286	556	T>I		No	ClinGen ExAC TOPMed gnomAD
rs752564786 CA5552284	557	C>S		No	ClinGen ExAC gnomAD
CA377184336 rs1337001067	558	I>V		No	ClinGen gnomAD
rs148683257 CA5552283	559	S>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA5552282 rs144173337	559	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs955992338 CA209581714	560	K>R		No	ClinGen Ensembl
CA377184294 rs1254478699	564	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs751105312 CA5552281	565	R>T		No	ClinGen ExAC gnomAD
rs149874709 CA5552280	566	N>S		No	ClinGen ESP ExAC gnomAD
rs1391991241 CA377184265	568	V>E		No	ClinGen gnomAD
CA5552265 rs781195580	569	E>V		No	ClinGen ExAC gnomAD
rs754659883 CA5552264	570	P>L		No	ClinGen ExAC gnomAD
CA377184243 rs1196753331	570	P>T		No	ClinGen TOPMed
CA5552263 rs368495430	571	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5552262 rs765950499	572	S>A		No	ClinGen ExAC gnomAD
rs757883984 CA5552261	572	S>C		No	ClinGen ExAC gnomAD
rs757883984 CA377184230	572	S>F		No	ClinGen ExAC gnomAD
TCGA novel	574	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA377184218 rs1589676249	574	T>N		No	ClinGen Ensembl
CA5552259 rs765752296	576	D>G		No	ClinGen ExAC TOPMed gnomAD
CA5552260 rs139138878	576	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs762346877 CA5552258	580	D>Y		No	ClinGen ExAC gnomAD
CA377184166 rs1403926951	582	E>K		No	ClinGen gnomAD
rs867922732 CA209581040	583	D>Y		No	ClinGen Ensembl
CA5552256 rs35331959	584	S>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs761033931 CA5552255	585	G>D		No	ClinGen ExAC TOPMed gnomAD
COSM1666367 COSM1666366 CA5552254 rs377196140	586	T>M	eye pancreas [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs1390627710 CA377184136	587	G>R		No	ClinGen gnomAD
rs1442402867 CA377184116	590	V>I		No	ClinGen gnomAD
CA377184110 rs1167873331	591	M>L		No	ClinGen TOPMed
CA5552253 rs772208142	591	M>T		No	ClinGen ExAC TOPMed gnomAD
rs1210238819 CA377184101	592	A>P		No	ClinGen gnomAD
rs1466266439 CA377184097	592	A>V		No	ClinGen TOPMed
rs769855078 CA5552250	594	V>I		No	ClinGen ExAC gnomAD
CA377184081 rs1203721043	595	D>G		No	ClinGen gnomAD
rs1257240907 CA377184073	596	V>A		No	ClinGen gnomAD
CA5552249 rs748150914	596	V>I		No	ClinGen ExAC gnomAD
CA377184076 rs748150914	596	V>L		No	ClinGen ExAC gnomAD
rs201794246 CA5552248	597	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA377184068 rs1245432805	597	D>G		No	ClinGen gnomAD
rs779706766 CA5552245	598	L>V		No	ClinGen ExAC TOPMed gnomAD
COSM427870 CA209581007 rs962509611	599	N>K	Variant assessed as Somatic; impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated Ensembl NCI-TCGA
CA5552242 rs141589370	604	I>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5552241 rs756774479	604	I>M		No	ClinGen ExAC TOPMed gnomAD
CA209580994 rs1010974436	605	L>W		No	ClinGen TOPMed
rs1485557842 CA377184000	608	Y>C		No	ClinGen TOPMed
rs1589676069 CA377184003	608	Y>H		No	ClinGen Ensembl
rs754277869 CA5552240	609	S>R		No	ClinGen ExAC gnomAD
rs1386559547 CA377183974	612	A>P		No	ClinGen Ensembl
CA377183955 rs1564658113	615	A>E		No	ClinGen Ensembl
rs764617729 CA5552239	621	L>P		No	ClinGen ExAC
rs1415482199 CA377183876	627	V>M		No	ClinGen gnomAD
rs767751204 CA5552233	631	D>G		No	ClinGen ExAC gnomAD
rs1180575438 CA377183845	632	N>D		No	ClinGen gnomAD
rs1003723347 CA209580965	632	N>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA377183835 rs1275743834	633	T>N		No	ClinGen gnomAD
VAR_051973 CA5552230 rs2271904	634	D>G		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA5552231 COSM920250 rs754498552	634	D>N	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs763126112 CA5552229	637	P>R		No	ClinGen ExAC TOPMed gnomAD
CA5552228 rs571686264	638	T>A		No	ClinGen 1000Genomes ExAC gnomAD
rs1411546026 CA377183798	639	S>N		No	ClinGen gnomAD
rs1011879083 CA209580946	640	K>N		No	ClinGen Ensembl
rs928987211 CA209580943	641	P>S		No	ClinGen TOPMed gnomAD

No associated diseases with O95905

No regional properties for O95905

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for O95905

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Nucleus	Predominantly is located in the cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name	Definition
histone acetyltransferase binding	Binding to an histone acetyltransferase.

5 GO annotations of biological process

Name	Definition
fibroblast proliferation	The multiplication or reproduction of fibroblast cells, resulting in the expansion of the fibroblast population.
mRNA processing	Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of G1/S transition of mitotic cell cycle	Any signalling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.
RNA splicing	The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9CS74	Ecd	Protein ecdysoneless homolog	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MEETMKLATM	EDTVEYCLFL	IPDESRDSDK	HKEILQKYIE	RIITRFAPML	VPYIWQNQPF
70	80	90	100	110	120
NLKYKPGKGG	VPAHMFGVTK	FGDNIEDEWF	IVYVIKQITK	EFPELVARIE	DNDGEFLLIE
130	140	150	160	170	180
AADFLPKWLD	PENSTNRVFF	CHGELCIIPA	PRKSGAESWL	PTTPPTIPQA	LNIITAHSEK
190	200	210	220	230	240
ILASESIRAA	VNRRIRGYPE	KIQASLHRAH	CFLPAGIVAV	LKQRPRLVAA	AVQAFYLRDP
250	260	270	280	290	300
IDLRACRVFK	TFLPETRIMT	SVTFTKCLYA	QLVQQRFVPD	RRSGYRLPPP	SDPQYRAHEL
310	320	330	340	350	360
GMKLAHGFEI	LCSKCSPHFS	DCKKSLVTAS	PLWASFLESL	KKNDYFKGLI	EGSAQYRERL
370	380	390	400	410	420
EMAENYFQLS	VDWPESSLAM	SPGEEILTLL	QTIPFDIEDL	KKEAANLPPE	DDDQWLDLSP
430	440	450	460	470	480
DQLDQLLQEA	VGKKESESVS	KEEKEQNYDL	TEVSESMKAF	ISKVSTHKGA	ELPREPSEAP
490	500	510	520	530	540
ITFDADSFLN	YFDKILGPRP	NESDSDDLDD	EDFECLDSDD	DLDFETHEPG	EEASLKGTLD
550	560	570	580	590	600
NLKSYMAQMD	QELAHTCISK	SFTTRNQVEP	VSQTTDNNSD	EEDSGTGESV	MAPVDVDLNL
610	620	630	640
VSNILESYSS	QAGLAGPASN	LLQSMGVQLP	DNTDHRPTSK	PTKN