AiPD: Autoinhibited Protein Database

O95502

Gene name	NPTXR
Protein name	Neuronal pentraxin receptor
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:23467
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

3-313 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

3-313 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for O95502

Entry ID	Method	Resolution	Chain	Position	Source
AF-O95502-F1	Predicted				AlphaFoldDB

411 variants for O95502

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA411568260 rs1172165768	4	L>V		No	ClinGen TOPMed
CA411568154 rs1293889448	9	A>T		No	ClinGen gnomAD
TCGA novel	10	A>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1269674813 CA411568126	11	G>D		No	ClinGen gnomAD
rs1195353899 CA411568101	12	M>I		No	ClinGen gnomAD
rs1479764956 CA411568083	14	A>V		No	ClinGen gnomAD
CA324316943 rs866660947	18	A>S		No	ClinGen Ensembl
CA411567882 rs1253335754	25	S>I		No	ClinGen gnomAD
TCGA novel	29	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA411567806 rs1283815789	30	A>S		No	ClinGen gnomAD
rs1056963113 CA324316942	30	A>V		No	ClinGen TOPMed
rs1443280999 CA411567781	31	S>C		No	ClinGen gnomAD
CA411567760 rs1448387745	32	P>A		No	ClinGen TOPMed
rs1228554608 CA411567735	33	A>E		No	ClinGen TOPMed gnomAD
rs1228554608 CA411567731	33	A>V		No	ClinGen TOPMed gnomAD
CA411567706 rs1352580907	35	A>P		No	ClinGen gnomAD
CA411567702 rs1311988581	35	A>V		No	ClinGen gnomAD
CA324316930 rs926956897	38	G>S		No	ClinGen TOPMed gnomAD
rs978429804 CA324316899	40	A>T		No	ClinGen TOPMed
rs1200613181 CA411567577	42	N>S		No	ClinGen TOPMed
CA411567559 rs1303990844	43	A>V		No	ClinGen Ensembl
rs1238795134 CA411567548	44	S>L		No	ClinGen TOPMed
CA411567541 rs1403919827	45	V>G		No	ClinGen TOPMed gnomAD
rs1468255731 CA411567544	45	V>L		No	ClinGen TOPMed
CA411567539 rs1413606126	46	A>T		No	ClinGen TOPMed gnomAD
CA411567529 rs1158772185	46	A>V		No	ClinGen gnomAD
rs1603247179 CA411567526	47	S>T		No	ClinGen Ensembl
CA324316898 rs565646758	48	G>V		No	ClinGen 1000Genomes TOPMed gnomAD
CA411567487 rs1467582528	50	A>G		No	ClinGen TOPMed
CA411567434 rs1490384947	54	G>D		No	ClinGen TOPMed gnomAD
CA411567429 rs1438323707	55	P>S		No	ClinGen TOPMed
rs1270922012 CA411567416	56	Q>P		No	ClinGen TOPMed gnomAD
CA411567402 rs1225883262	57	R>W		No	ClinGen TOPMed gnomAD
rs912978000 CA324316895	58	S>T		No	ClinGen TOPMed
CA324316851 rs1019824100	65	A>T		No	ClinGen TOPMed gnomAD
rs954317301 CA324316814	66	G>D		No	ClinGen TOPMed
CA324316802 rs1026979804	71	P>S		No	ClinGen TOPMed gnomAD
rs776494065 CA10236570	75	P>S		No	ClinGen ExAC TOPMed gnomAD
rs1398123477 CA411567178	76	G>E		No	ClinGen gnomAD
CA324316791 rs897213896	82	A>V		No	ClinGen TOPMed
rs1178392169 CA411567039	86	P>L		No	ClinGen TOPMed gnomAD
rs1178392169 CA411567037	86	P>R		No	ClinGen TOPMed gnomAD
rs1426933185 CA411567044	86	P>S		No	ClinGen TOPMed gnomAD
rs1426933185 CA411567047	86	P>T		No	ClinGen TOPMed gnomAD
rs1411206602 CA411567033	87	P>S		No	ClinGen gnomAD
CA411567031 rs1411206602	87	P>T		No	ClinGen gnomAD
rs1400587414 CA411567016	88	G>E		No	ClinGen TOPMed
CA324316761 rs1013698460	88	G>R		No	ClinGen TOPMed gnomAD
CA411567018 rs1013698460	88	G>W		No	ClinGen TOPMed gnomAD
CA411567008 rs1292633639	89	P>A		No	ClinGen TOPMed
rs895633404 CA324316758	89	P>H		No	ClinGen TOPMed gnomAD
rs895633404 CA411567003	89	P>L		No	ClinGen TOPMed gnomAD
rs1267229254 CA411566998	90	L>V		No	ClinGen TOPMed
CA411566980 rs1357409241	91	F>C		No	ClinGen TOPMed
CA411566960 rs1284388828	92	S>R		No	ClinGen TOPMed
rs1461092318 CA411566954	93	R>H		No	ClinGen gnomAD
CA411566923 rs1489459076	96	C>R		No	ClinGen TOPMed
rs1261646967 CA411566902	97	T>M		No	ClinGen gnomAD
CA411566888 rs1189019503	98	P>L		No	ClinGen TOPMed
CA411566892 rs1189019503	98	P>R		No	ClinGen TOPMed
rs1257456754 CA411566898	98	P>T		No	ClinGen TOPMed
rs1279510151 CA411566865	100	A>V		No	ClinGen gnomAD
rs1236180032 CA411566862	101	A>T		No	ClinGen gnomAD
rs1337018769 CA411566858	101	A>V		No	ClinGen gnomAD
rs1365212283 CA411566843	102	A>G		No	ClinGen Ensembl
CA411566832 rs1307167282	103	C>F		No	ClinGen gnomAD
CA324316743 rs937249928	104	P>L		No	ClinGen TOPMed
rs774816033 CA10236567	104	P>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	106	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA411566800 rs1403502269	106	G>W		No	ClinGen gnomAD
CA10236566 rs771503166	107	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1468608568 CA411566769	108	Q>H		No	ClinGen gnomAD
rs1365602175 CA411566749	109	Q>H		No	ClinGen gnomAD
rs1182696394 CA411566734	110	G>V		No	ClinGen gnomAD
rs1315014472 CA411566712	111	D>G		No	ClinGen TOPMed
rs1444211381 CA411566721	111	D>N		No	ClinGen gnomAD
CA324316725 rs947061877	112	A>E		No	ClinGen TOPMed
CA411566698 rs1462054077	112	A>T		No	ClinGen gnomAD
CA411566656 rs1238657119	113	A>V		No	ClinGen TOPMed
CA411566575 rs1279971347	117	P>L		No	ClinGen TOPMed
CA411566578 rs1279971347	117	P>R		No	ClinGen TOPMed
TCGA novel	118	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA411566386 rs1176183318	123	L>R		No	ClinGen TOPMed
rs1439855747 CA411566272	127	Q>R		No	ClinGen TOPMed
CA10236562 rs770206274	128	S>N		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	129	T>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA411566223 rs1435020171	129	T>P		No	ClinGen gnomAD
CA324316700 rs988955023	130	A>V		No	ClinGen TOPMed
TCGA novel	131	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1319313176 CA411566145	131	E>K		No	ClinGen gnomAD
CA411566093 rs1380076130	132	Q>R		No	ClinGen TOPMed gnomAD
rs943826554 CA324316694	135	Q>R		No	ClinGen TOPMed
rs781394016 CA10236560	136	T>M		No	ClinGen ExAC TOPMed gnomAD
rs1364200503 CA411565937	137	A>S		No	ClinGen gnomAD
rs866466540 CA324316686	137	A>V		No	ClinGen gnomAD
CA411565866 rs1402361758	140	Q>L		No	ClinGen TOPMed gnomAD
rs1402361758 CA411565874	140	Q>R		No	ClinGen TOPMed gnomAD
rs747132112 CA411565819	142	A>E		No	ClinGen ExAC gnomAD
rs747132112 CA10236558	142	A>V		No	ClinGen ExAC gnomAD
rs866809734 CA324316670	146	A>D		No	ClinGen Ensembl
rs758471421 CA10236556	147	D>V		No	ClinGen ExAC gnomAD
rs750375912 CA10236555	148	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs1409283809 CA411565690	151	I>N		No	ClinGen TOPMed gnomAD
CA411565692 rs1257123237	151	I>V		No	ClinGen TOPMed
CA411565686 rs1196213627	152	R>S		No	ClinGen TOPMed
rs765251881 CA10236554	153	E>V		No	ClinGen ExAC gnomAD
CA411565666 rs1158017068	155	T>A		No	ClinGen TOPMed gnomAD
CA411565659 rs1449203249	156	G>D		No	ClinGen gnomAD
rs371614157 CA411565661	156	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs371614157 CA10236552	156	G>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs867376995 CA324316605	157	K>N		No	ClinGen Ensembl
CA10236551 rs763863559	157	K>R		No	ClinGen ExAC gnomAD
CA324316602 rs867188659	158	L>M		No	ClinGen gnomAD
rs1356664861 CA411565639	160	R>G		No	ClinGen TOPMed gnomAD
rs1293413898 CA411565636	160	R>H		No	ClinGen gnomAD
rs1463934682 CA411565612	163	S>R		No	ClinGen TOPMed
CA411565615 rs1372442130	163	S>T		No	ClinGen TOPMed
rs1338413309 CA411565599	166	P>S		No	ClinGen gnomAD
TCGA novel	168	G>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs568351620 CA10236550	168	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1326902111 CA411565570	170	Q>H		No	ClinGen TOPMed gnomAD
rs974071606 CA324316586	171	G>C		No	ClinGen TOPMed
rs775179493 CA10236549	173	G>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	173	G>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10236548 rs766989044	174	P>R		No	ClinGen ExAC gnomAD
CA411565546 rs1242669857	175	R>G		No	ClinGen TOPMed gnomAD
rs764654952 CA324316559	175	R>H		No	ClinGen gnomAD
rs759078068 CA10236547	176	R>L		No	ClinGen ExAC gnomAD
rs1165611245 CA411565541	176	R>S		No	ClinGen gnomAD
CA411565526 rs1307491061	178	T>I		No	ClinGen TOPMed
CA411565518 rs1166472395	179	M>R		No	ClinGen gnomAD
rs1259490935 CA411565522	179	M>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA411565497 rs1374082946	182	G>E		No	ClinGen TOPMed gnomAD
rs1199337986 CA411565482	184	W>*		No	ClinGen gnomAD
CA411565476 rs1489223042	185	D>G		No	ClinGen TOPMed
CA324316526 rs1014083450	185	D>N		No	ClinGen TOPMed gnomAD
rs115826781 CA10236545	186	S>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA411565462 rs1222649281	187	P>H		No	ClinGen gnomAD
CA411565465 rs1260768037	187	P>S		No	ClinGen TOPMed
rs1436832847 CA411565457	188	A>G		No	ClinGen gnomAD
rs1172705655 CA411565461	188	A>T		No	ClinGen TOPMed
CA10236544 rs748522267	191	L>M		No	ClinGen ExAC TOPMed gnomAD
CA324316483 rs988665176	194	E>*		No	ClinGen gnomAD
rs1347371160 CA411565355	198	R>S		No	ClinGen gnomAD
rs957267172 CA324316467	199	A>T		No	ClinGen TOPMed gnomAD
CA411565312 rs1354111793	201	R>W		No	ClinGen gnomAD
rs1411942030 CA411565282	202	D>E		No	ClinGen gnomAD
TCGA novel	202	D>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA411565276 rs1424784566	203	R>C		No	ClinGen TOPMed gnomAD
CA411565274 rs1176234635	203	R>H		No	ClinGen gnomAD
CA411565272 rs1176234635	203	R>P		No	ClinGen gnomAD
rs747234733 CA10236541	205	D>G		No	ClinGen ExAC TOPMed gnomAD
CA324316453 rs1043380924	205	D>H		No	ClinGen TOPMed
rs1432137721 CA411565219	206	R>L		No	ClinGen gnomAD
rs920460278 CA324303828	211	L>F		No	ClinGen gnomAD
rs755919030 CA10236533	212	P>S		No	ClinGen ExAC gnomAD
rs752354485 CA10236532	213	A>V		No	ClinGen ExAC gnomAD
CA324303807 rs866663029	214	R>C		No	ClinGen TOPMed gnomAD
rs767199079 CA10236531	214	R>H		No	ClinGen ExAC TOPMed gnomAD
rs767199079 CA411561243	214	R>P		No	ClinGen ExAC TOPMed gnomAD
CA324303802 rs866663029	214	R>S		No	ClinGen TOPMed gnomAD
rs1242177819 CA411561236	215	V>M		No	ClinGen gnomAD
CA411561220 rs1603245346	216	N>T		No	ClinGen Ensembl
CA10236529 rs374110111	217	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA411561177 rs762265043	220	A>S		No	ClinGen ExAC TOPMed gnomAD
rs762265043 CA10236527	220	A>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	220	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA411561162 rs1282217530	221	P>S		No	ClinGen gnomAD
rs572544703 CA10236525	222	A>V		No	ClinGen 1000Genomes ExAC gnomAD
CA10236523 rs775640516	223	P>S		No	ClinGen ExAC gnomAD
TCGA novel	228	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	228	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1430615454 CA411561068	229	T>I		No	ClinGen gnomAD
rs192020239 CA324303739	230	G>D		No	ClinGen 1000Genomes gnomAD
rs779097745 CA10236520	230	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1419799185 CA411561039	232	H>Q		No	ClinGen gnomAD
rs771105329 CA10236519	233	S>A		No	ClinGen ExAC gnomAD
rs371797046 CA10236518	235	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA411560983 rs1258016974	237	Q>K		No	ClinGen gnomAD
rs1256585172 CA411560961	238	L>P		No	ClinGen gnomAD
CA411560969 rs777755585	238	L>V		No	ClinGen ExAC gnomAD
rs1382147032 CA411560958	239	E>K		No	ClinGen TOPMed
TCGA novel	244	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1311718378 CA411560872	245	Q>H		No	ClinGen gnomAD
rs1243809273 CA411560874	245	Q>P		No	ClinGen gnomAD
rs1603245330 CA411560859	246	V>G		No	ClinGen Ensembl
CA10236513 rs754572836	247	L>V		No	ClinGen ExAC gnomAD
rs1354507247 CA411560822	250	E>K		No	ClinGen gnomAD
rs765911529 CA10236510	252	E>G		No	ClinGen ExAC TOPMed gnomAD
rs762426363 CA10236509 COSM580280	253	R>C	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs762426363 CA411560776	253	R>G		No	ClinGen ExAC TOPMed gnomAD
CA10236508 rs376328414	253	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	253	R>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	254	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA411560756 rs1427721227	255	A>T		No	ClinGen Ensembl
CA411560743 rs1291153243	256	L>F		No	ClinGen gnomAD
rs1364406153 CA411560700	259	S>G		No	ClinGen gnomAD
rs1380831947 CA411560691	259	S>R		No	ClinGen gnomAD
rs200507552 COSM1416289 CA10236505	261	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA411560656 rs145832617	262	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10236502 rs145832617	262	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs772216123 CA10236503	262	R>W		No	ClinGen ExAC TOPMed gnomAD
rs774695782 CA10236501	264	R>G		No	ClinGen ExAC TOPMed gnomAD
CA10236500 rs771195311	264	R>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs749378393 CA10236499	264	R>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	265	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	265	Q>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10236498 rs777580982	266	E>K		No	ClinGen ExAC
rs1603245311 CA411560593	267	V>G		No	ClinGen Ensembl
rs769709888 CA10236497	267	V>M		No	ClinGen ExAC gnomAD
CA411560542 rs1568984675	270	E>D		No	ClinGen Ensembl
CA411560553 rs1220403859	270	E>G		No	ClinGen gnomAD
rs146892527 CA324303605	271	L>S		No	ClinGen ESP
rs780997596 CA411560539	271	L>V		No	ClinGen ExAC TOPMed gnomAD
rs1306127665 CA411560506	273	V>A		No	ClinGen gnomAD
CA324303601 rs751260752	273	V>I		No	ClinGen ExAC TOPMed gnomAD
rs751260752 CA10236493	273	V>L		No	ClinGen ExAC TOPMed gnomAD
rs1375821112 CA411560500	274	L>P		No	ClinGen TOPMed
rs779666889 CA10236492	275	Q>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
TCGA novel	276	G>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs757970245 CA324303588	276	G>C		No	ClinGen ExAC TOPMed gnomAD
rs1174369821 CA411560457	276	G>D		No	ClinGen TOPMed
rs757970245 CA10236491	276	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA10236490 rs181616480	277	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs764531302 CA10236489	279	A>P		No	ClinGen ExAC gnomAD
CA411560406 rs764531302	279	A>S		No	ClinGen ExAC gnomAD
COSM726302 CA324303552 rs887146414	280	E>K	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs1379590060 CA411560303	282	E>G		No	ClinGen TOPMed
rs1027666438 CA324303547	282	E>Q		No	ClinGen TOPMed
rs1603245084 CA411560005	284	G>E		No	ClinGen Ensembl
CA324303534 rs972112990	284	G>R		No	ClinGen TOPMed gnomAD
CA411559993 rs1247151929	285	S>P		No	ClinGen gnomAD
CA324302324 rs375154090	289	S>G		No	ClinGen TOPMed gnomAD
CA411559814 rs1346384680	291	P>L		No	ClinGen TOPMed gnomAD
TCGA novel	293	A>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1321608569 CA411559784	293	A>T		No	ClinGen TOPMed
rs1259596068 CA411559768	293	A>V		No	ClinGen gnomAD
TCGA novel	295	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1355342267 CA411559675	297	S>N		No	ClinGen gnomAD
CA10236466 rs768131103	299	P>R		No	ClinGen ExAC TOPMed gnomAD
CA324302300 rs905832793	300	I>N		No	ClinGen TOPMed
rs755394676 CA411559607	301	R>C		No	ClinGen ExAC TOPMed gnomAD
rs763198430 CA10236462	301	R>H		No	ClinGen ExAC TOPMed gnomAD
CA10236464 rs763198430	301	R>L		No	ClinGen ExAC TOPMed gnomAD
rs763198430 CA10236463	301	R>P		No	ClinGen ExAC TOPMed gnomAD
CA10236465 rs755394676	301	R>S		No	ClinGen ExAC TOPMed gnomAD
CA10236461 rs773278031	302	N>S		No	ClinGen ExAC gnomAD
CA10236458 rs776617870	304	Y>C		No	ClinGen ExAC gnomAD
CA411559556 rs768515182	305	M>L		No	ClinGen ExAC TOPMed gnomAD
CA324302236 rs1018157501	305	M>T		No	ClinGen Ensembl
CA10236457 rs768515182	305	M>V		No	ClinGen ExAC TOPMed gnomAD
CA10236455 rs775225739	307	A>T		No	ClinGen ExAC TOPMed gnomAD
rs140101072 CA10236454	308	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs140101072 CA324302226	308	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs745582200 CA10236453	308	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA10236450 rs368736692	309	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
COSM289095 CA10236451 rs368736692	309	V>M	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA10236448 rs376313574	310	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA10236447 rs376313574	310	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA10236449 rs568659250	310	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	311	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1244429569 CA411559386	314	P>L		No	ClinGen TOPMed
rs1355228425 CA411559394	314	P>S		No	ClinGen TOPMed gnomAD
CA10236443 rs750717348	315	E>K		No	ClinGen ExAC TOPMed gnomAD
CA10236442 rs765375184	316	L>F		No	ClinGen ExAC gnomAD
rs5757299 CA411559307	317	Y>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs753857826 CA10236440	318	A>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	320	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1603245054 CA411559243	320	T>P		No	ClinGen Ensembl
rs1325738969 CA411559234	320	T>S		No	ClinGen gnomAD
rs764050642 CA10236439	321	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs760645476 CA10236438	321	A>V		No	ClinGen ExAC
CA411559199 rs775381952	322	C>S		No	ClinGen ExAC gnomAD
CA10236437 rs775381952	322	C>Y		No	ClinGen ExAC gnomAD
CA10236435 rs759244826	323	M>I		No	ClinGen ExAC gnomAD
CA10236436 rs117273127	323	M>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1362536720 CA411559186	323	M>V		No	ClinGen gnomAD
rs750112469 CA411559104	325	L>V		No	ClinGen ExAC TOPMed gnomAD
CA10236432 rs748848563	326	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA10236433 rs34637063	326	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1244526016 CA411559061	327	S>Y		No	ClinGen gnomAD
CA411559043 rs1372938933	328	R>G		No	ClinGen gnomAD
CA411559006 rs1603245041	329	S>A		No	ClinGen Ensembl
rs1046052614 CA324302071	329	S>F		No	ClinGen Ensembl
CA411558897 rs1263252238	331	G>D		No	ClinGen gnomAD
rs769401848 CA10236430	331	G>S		No	ClinGen ExAC TOPMed gnomAD
CA411558891 rs1603245038	332	T>P		No	ClinGen Ensembl
CA10236428 rs780696214	333	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1556030490 CA411558817	334	Q>R		No	ClinGen Ensembl
CA10236427 rs758866290	335	G>S		No	ClinGen ExAC TOPMed gnomAD
CA411558783 rs1303675585	335	G>V		No	ClinGen gnomAD
rs1603245032 CA411558769	336	T>P		No	ClinGen Ensembl
CA10236425 rs779210615	337	P>L		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	338	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10236422 rs200083748	344	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA411558561 rs1277256768	345	Q>K		No	ClinGen TOPMed
rs1396204676 CA411558509	347	N>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA411558510 rs1396204676	347	N>S		No	ClinGen gnomAD
rs1352149299 CA411557457	348	E>D		No	ClinGen TOPMed
COSM1259410 CA10236417 rs773964723	348	E>K	oesophagus [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs770644558 CA10236416	349	I>T		No	ClinGen ExAC gnomAD
TCGA novel	350	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10236415 rs762739466	350	V>L		No	ClinGen ExAC gnomAD
CA411557316 rs1277423998	354	A>T		No	ClinGen TOPMed
CA10236414 rs375259496	354	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA411557276 rs1270598637	355	G>D		No	ClinGen gnomAD
CA10236413 rs769489717	358	P>S		No	ClinGen ExAC TOPMed gnomAD
CA10236412 rs747658539	359	M>L		No	ClinGen ExAC gnomAD
CA10236410 rs530212748	364	N>K		No	ClinGen 1000Genomes ExAC gnomAD
rs147434453 CA10236411	364	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10236408 rs779185093	365	D>N		No	ClinGen ExAC TOPMed gnomAD
CA411555732 rs1484172790	367	V>M		No	ClinGen gnomAD
rs777981656 CA10236385	368	A>T		No	ClinGen ExAC gnomAD
rs1284060078 CA411555462	373	S>R		No	ClinGen gnomAD
CA411555436 rs1242574431	374	L>Q		No	ClinGen gnomAD
CA10236380 rs751513427	376	D>G		No	ClinGen ExAC gnomAD
CA10236381 rs755066146	376	D>N		No	ClinGen ExAC gnomAD
CA10236379 rs367643098	377	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1303934210 CA411555184	379	W>C		No	ClinGen gnomAD
rs1603244529 CA411555181	380	H>N		No	ClinGen Ensembl
CA10236378 rs758273667	381	H>Q		No	ClinGen ExAC TOPMed gnomAD
CA10236377 rs750187014	382	I>M		No	ClinGen ExAC gnomAD
CA411555062 rs1358060128	382	I>V		No	ClinGen gnomAD
CA411554986 rs1419894607	384	I>T		No	ClinGen gnomAD
CA324298937 rs900977014	384	I>V		No	ClinGen TOPMed
rs139705044 CA10236375	385	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10236374 rs776324465	385	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1199573654 CA411554860	389	R>G		No	ClinGen TOPMed
rs150632579 CA10236373	389	R>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs1486561339 CA411554799	390	D>G		No	ClinGen TOPMed
CA411554796 rs1188404589	391	G>S		No	ClinGen TOPMed
rs1300562131 CA411554549	397	Q>R		No	ClinGen gnomAD
CA324298898 rs959559163	398	D>H		No	ClinGen Ensembl
rs267606249 CA324298844	399	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs771367258 CA10236370	399	G>R		No	ClinGen ExAC TOPMed gnomAD
rs749673283 CA10236369	403	G>S		No	ClinGen ExAC TOPMed gnomAD
rs773522042 CA10236368	405	G>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	408	L>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10236367 rs770110091	410	A>S		No	ClinGen ExAC TOPMed gnomAD
CA411554100 rs111874702	412	H>N		No	ClinGen gnomAD
CA411554070 rs1291434740	412	H>Q		No	ClinGen gnomAD
CA324298799 rs111874702	412	H>Y		No	ClinGen gnomAD
CA411554043 rs1459182587	414	I>T		No	ClinGen gnomAD
CA10236365 rs1556029881	414	I>V		No	ClinGen Ensembl
TCGA novel	416	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1169547911 CA411554001	416	P>R		No	ClinGen gnomAD
CA10236364 rs748371400	416	P>S		No	ClinGen ExAC gnomAD
TCGA novel	418	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA324298785 rs1010872135	421	I>T		No	ClinGen Ensembl
CA10236362 rs755083133	423	G>C		No	ClinGen ExAC gnomAD
CA10236361 rs747046423	425	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1603244467 CA411553888	428	T>P		No	ClinGen Ensembl
CA411553846 rs967248905	431	G>D		No	ClinGen TOPMed gnomAD
CA324298590 rs967248905	431	G>V		No	ClinGen TOPMed gnomAD
CA324298588 rs371378883	432	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA10236342 rs371378883	432	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA411553842 rs1187072442	432	R>W		No	ClinGen TOPMed gnomAD
CA10236341 rs200610146	433	F>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs893843282 CA324298556	434	D>V		No	ClinGen TOPMed
rs757005174 CA10236339	435	A>S		No	ClinGen ExAC TOPMed gnomAD
rs757005174 CA411553810	435	A>T		No	ClinGen ExAC TOPMed gnomAD
rs753609252 CA10236338	436	T>I		No	ClinGen ExAC
CA411553796 rs1603244459	436	T>P		No	ClinGen Ensembl
rs777309805 CA10236337	438	A>D		No	ClinGen ExAC gnomAD
rs777309805 CA411553747	438	A>G		No	ClinGen ExAC gnomAD
CA411553717 rs1296489241	440	V>I		No	ClinGen TOPMed
rs767059132 CA10236334	441	G>D		No	ClinGen ExAC gnomAD
rs752310738 CA10236335	441	G>S		No	ClinGen ExAC TOPMed gnomAD
CA411553652 rs1331843256	443	I>T		No	ClinGen gnomAD
CA324298513 rs1037089429	445	Q>H		No	ClinGen TOPMed
rs759036936 CA10236333	446	F>L		No	ClinGen ExAC gnomAD
CA411553552 rs1400019249	449	W>*		No	ClinGen gnomAD
rs1301112617 CA411553539	450	D>H		No	ClinGen gnomAD
rs1569326496 CA411553531	450	D>V		No	ClinGen Ensembl
CA10236331 rs765667798	451	H>R		No	ClinGen ExAC gnomAD
CA10236332 rs138349722	451	H>Y		No	ClinGen ESP ExAC gnomAD
CA10236329 rs61737784 COSM3964289	452	A>T	lung [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA411553466 rs1382533717	455	P>L		No	ClinGen TOPMed gnomAD
rs1382533717 CA411553461	455	P>Q		No	ClinGen TOPMed gnomAD
CA324298486 rs189589858	456	A>P		No	ClinGen 1000Genomes gnomAD
CA411553459 rs189589858	456	A>T		No	ClinGen 1000Genomes gnomAD
rs1201618291 CA411553337	463	N>K		No	ClinGen gnomAD
rs760997710 CA10236327	463	N>Y		No	ClinGen ExAC gnomAD
CA411553319 rs1483286501	464	C>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA411553301 rs201081137	465	T>A		No	ClinGen ExAC TOPMed gnomAD
rs201081137 CA10236326	465	T>S		No	ClinGen ExAC TOPMed gnomAD
rs745876945 CA10236324	466	A>V		No	ClinGen ExAC TOPMed gnomAD
CA411553234 rs1243821312	467	P>S		No	ClinGen gnomAD
rs770851355 CA10236322	471	N>D		No	ClinGen ExAC TOPMed gnomAD
rs749066113 CA10236321	472	V>I		No	ClinGen ExAC gnomAD
CA324298430 rs925461793	473	L>V		No	ClinGen TOPMed gnomAD
rs920280469 CA324298429	476	E>D		No	ClinGen TOPMed
rs1297713817 CA411553025	476	E>G		No	ClinGen gnomAD
rs376143434 CA10236319	480	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs747852955 CA10236318	481	E>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	482	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs937645787 CA324298403	485	G>C		No	ClinGen Ensembl
CA411552749 rs1449292738	486	A>T		No	ClinGen gnomAD
CA411552723 rs1378228063	487	T>A		No	ClinGen TOPMed
CA411552707 rs754268800	487	T>I		No	ClinGen ExAC TOPMed gnomAD
rs754268800 CA10236312	487	T>K		No	ClinGen ExAC TOPMed gnomAD
CA324298377 rs914182461	489	A>G		No	ClinGen TOPMed
rs1286301565 CA411552603	490	A>V		No	ClinGen gnomAD
CA10236309 rs775859393	492	D>G		No	ClinGen ExAC gnomAD
CA10236310 rs760942378	492	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1440179701 CA411552456	494	C>Y		No	ClinGen gnomAD
rs767789051 CA10236308	495	K>N		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	496	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1277605570 CA411552395	497	R>K		No	ClinGen TOPMed gnomAD
rs367835542 CA10236307	498	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
rs148816112 CA10236305	500	A>V		No	ClinGen ESP ExAC gnomAD

No associated diseases with O95502

No regional properties for O95502

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for O95502

Functions

		Description
EC Number
Subcellular Localization	Membrane ; Single-pass type II membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
glutamatergic synapse	A synapse that uses glutamate as a neurotransmitter.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

1 GO annotations of molecular function

Name	Definition
metal ion binding	Binding to a metal ion.

1 GO annotations of biological process

Name	Definition
regulation of postsynaptic neurotransmitter receptor activity	Any process that modulates the frequency, rate or extent of neurotransmitter receptor activity involved in synaptic transmission. Modulation may be via an effect on ligand affinity, or effector funtion such as ion selectivity or pore opening/closing in ionotropic receptors.

3 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P47972	NPTX2	Neuronal pentraxin-2	Homo sapiens (Human)	PR
Q99J85	Nptxr	Neuronal pentraxin receptor	Mus musculus (Mouse)	PR
O35764	Nptxr	Neuronal pentraxin receptor	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MKFLAVLLAA	GMLAFLGAVI	CIIASVPLAA	SPARALPGGA	DNASVASGAA	ASPGPQRSLS
70	80	90	100	110	120
ALHGAGGSAG	PPALPGAPAA	SAHPLPPGPL	FSRFLCTPLA	AACPSGAQQG	DAAGAAPGER
130	140	150	160	170	180
EELLLLQSTA	EQLRQTALQQ	EARIRADQDT	IRELTGKLGR	CESGLPRGLQ	GAGPRRDTMA
190	200	210	220	230	240
DGPWDSPALI	LELEDAVRAL	RDRIDRLEQE	LPARVNLSAA	PAPVSAVPTG	LHSKMDQLEG
250	260	270	280	290	300
QLLAQVLALE	KERVALSHSS	RRQRQEVEKE	LDVLQGRVAE	LEHGSSAYSP	PDAFKISIPI
310	320	330	340	350	360
RNNYMYARVR	KALPELYAFT	ACMWLRSRSS	GTGQGTPFSY	SVPGQANEIV	LLEAGHEPME
370	380	390	400	410	420
LLINDKVAQL	PLSLKDNGWH	HICIAWTTRD	GLWSAYQDGE	LQGSGENLAA	WHPIKPHGIL
430	440	450	460	470	480
ILGQEQDTLG	GRFDATQAFV	GDIAQFNLWD	HALTPAQVLG	IANCTAPLLG	NVLPWEDKLV
490
EAFGGATKAA	FDVCKGRAKA