O35764

PR
Gene name
Nptxr (Npr)
Protein name
Neuronal pentraxin receptor
Names
Species
Rattus norvegicus (Rat)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

3-307 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O35764

Entry ID Method Resolution Chain Position Source
AF-O35764-F1 Predicted AlphaFoldDB

No variants for O35764

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O35764

No associated diseases with O35764

No regional properties for O35764

Type Name Position InterPro Accession
No domain, repeats, and functional sites for O35764

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Single-pass type II membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
glutamatergic synapse A synapse that uses glutamate as a neurotransmitter.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

4 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
pentraxin receptor activity Combining with a pentraxin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
protein phosphatase binding Binding to a protein phosphatase.
protein-containing complex binding Binding to a macromolecular complex.

5 GO annotations of biological process

Name Definition
neuron projection development The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
neurotransmitter receptor localization to postsynaptic specialization membrane A process in which a neurotransmitter is transported to, or maintained in, a location within the membrane adjacent to a postsynaptic specialization (e.g. postsynaptic density).
regulation of postsynaptic neurotransmitter receptor activity Any process that modulates the frequency, rate or extent of neurotransmitter receptor activity involved in synaptic transmission. Modulation may be via an effect on ligand affinity, or effector funtion such as ion selectivity or pore opening/closing in ionotropic receptors.
regulation of postsynaptic specialization assembly Any process that modulates the frequency, rate or extent of postsynaptic specialization assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynaptic specialization.
response to hydrogen peroxide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O95502 NPTXR Neuronal pentraxin receptor Homo sapiens (Human) PR
Q99J85 Nptxr Neuronal pentraxin receptor Mus musculus (Mouse) PR
10 20 30 40 50 60
MKFLAVLLAA GMLAFLGAVI CIIASVPLAA SPARALPGGT DNASAASAAG APGPQRSLSA
70 80 90 100 110 120
LQGAGGSAGP SVLPGEPAAS VFPPPPGPLL SRFLCTPLAA ACPSGAEQGD AAGERAELLL
130 140 150 160 170 180
LQSTAEQLRQ TALQQEARIR ADRDTIRELT GKLGRCESGL PRGLQDAGPR RDTMADGAWD
190 200 210 220 230 240
SPALLVELEN AVRALRDRIE RIEQELPARG NLSSSAPAPA VPTALHSKMD ELEGQLLAKV
250 260 270 280 290 300
LALEKERAAL SHGSHQQRQE VEKELDALQG RVAELEHGSS AYSPPDAFKV SIPIRNNYMY
310 320 330 340 350 360
ARVRKAVPEL YAFTACMWLR SRSGGSGQGT PFSYSVPGQA NEIVLLEAGL EPMELLINDK
370 380 390 400 410 420
VAQLPLSLKD SNWHHICIAW TTRDGLWSAY QDGELRGSGE NLAAWHPIKP HGILILGQEQ
430 440 450 460 470 480
DTLGGRFDAT QAFVGDIAQF NLWDHALTPA QVLGIANCTG PLMGNVLPWE DKLVEAFGGA
490
KKAAFDVCKR RAKA