AiPD: Autoinhibited Protein Database

O95456

Gene name	PSMG1 (C21LRP, DSCR2, PAC1)
Protein name	Proteasome assembly chaperone 1
Names	PAC-1, Chromosome 21 leucine-rich protein, C21-LRP, Down syndrome critical region protein 2
Species	Homo sapiens (Human)
KEGG Pathway	hsa:8624
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-63 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-63 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

7 structures for O95456

Entry ID	Method	Resolution	Chain	Position	Source
8QYJ	EM	273 A	I	1-288	PDB
8QYL	EM	267 A	I	1-288	PDB
8QYM	EM	273 A	I	1-288	PDB
8QYN	EM	288 A	I	1-288	PDB
8QYS	EM	389 A	I/Z	1-288	PDB
8QZ9	EM	295 A	I	1-288	PDB
AF-O95456-F1	Predicted				AlphaFoldDB

233 variants for O95456

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA320549862 rs866435612	2	A>V		No	ClinGen Ensembl
CA409953130 rs1234735136	3	A>G		No	ClinGen gnomAD
CA10026112 rs774016846	3	A>S		No	ClinGen ExAC gnomAD
CA10026111 rs374405896	4	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs762712818 CA10026110	5	F>V		No	ClinGen ExAC gnomAD
rs773130013 CA10026109	6	F>Y		No	ClinGen ExAC gnomAD
CA10026108 rs769699401	10	V>L		No	ClinGen ExAC gnomAD
rs568027634 CA10026107	12	A>V		No	ClinGen 1000Genomes ExAC gnomAD
CA10026105 rs150047855	13	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA409953005 rs150047855	13	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1239246938 CA409952998	14	C>G		No	ClinGen gnomAD
CA409952985 rs1178582445	15	R>*		No	ClinGen TOPMed gnomAD
CA409952987 rs1178582445	15	R>G	Variant assessed as Somatic; 6.48e-05 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1456869014 CA409952980	15	R>L		No	ClinGen TOPMed gnomAD
rs1456869014 CA409952982	15	R>Q		No	ClinGen TOPMed gnomAD
rs1255278607 CA409952976	16	A>T		No	ClinGen gnomAD
rs1249340333 CA409952926	19	E>D		No	ClinGen TOPMed gnomAD
rs973547342 CA320549833	20	D>G		No	ClinGen Ensembl
rs747051823 CA10026104	20	D>Y		No	ClinGen ExAC gnomAD
rs1230909834 CA409952858	24	E>G		No	ClinGen gnomAD
CA409952842 rs1264515977	25	E>A		No	ClinGen gnomAD
CA409952828 rs1401966239	26	E>G		No	ClinGen TOPMed
rs1318204634 CA409952800	28	R>Q		No	ClinGen gnomAD
rs940866544 CA320549800	31	T>M		No	ClinGen Ensembl
CA320549799 rs908046069	32	P>L		No	ClinGen gnomAD
CA409952751 rs1445942861	32	P>S		No	ClinGen gnomAD
CA409952738 rs1390233703	33	E>G		No	ClinGen gnomAD
rs758557571 CA10026099	33	E>K		No	ClinGen ExAC TOPMed gnomAD
CA10026097 rs779138348	34	D>N		No	ClinGen ExAC gnomAD
CA320549771 rs377036386	35	R>G		No	ClinGen ESP TOPMed
rs1158196088 CA409952707	35	R>S		No	ClinGen gnomAD
CA409952712 rs1380985322	35	R>T		No	ClinGen gnomAD
CA320549729 rs1127135	39	L>P		No	ClinGen Ensembl
CA409952641 rs1207718310	40	Q>H		No	ClinGen gnomAD
rs1251625025 CA409952646	40	Q>P		No	ClinGen TOPMed
rs756716291 CA10026092	43	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA10026090 rs200000347	44	K>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs200000347 CA10026091	44	K>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA409952592 rs1280738908	45	R>G		No	ClinGen TOPMed
CA409951964 rs1200261799	46	E>K		No	ClinGen gnomAD
rs1318341073 CA409951949	47	V>M		No	ClinGen gnomAD
CA409951934 rs1217019928	48	R>Q		No	ClinGen TOPMed gnomAD
rs748645572 CA10026056	48	R>W		No	ClinGen ExAC gnomAD
CA10026055 rs781746651	51	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs755573511 CA10026054	51	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA409951894 rs1447461500	52	R>K		No	ClinGen gnomAD
CA10026053 rs749882643	53	Q>*		No	ClinGen ExAC gnomAD
CA409951881 rs1466411106	53	Q>R		No	ClinGen TOPMed gnomAD
rs756920485 CA10026051	56	T>P		No	ClinGen ExAC gnomAD
CA409951835 rs1175632413	57	S>P		No	ClinGen TOPMed
rs139346791 CA320548319	59	E>D		No	ClinGen ESP TOPMed
CA10026050 rs753499198	59	E>K		No	ClinGen ExAC gnomAD
CA409951795 rs1471033956	60	V>A		No	ClinGen TOPMed
rs147961251 CA320548312	60	V>L		No	ClinGen ESP
CA10026049 rs763844375	61	S>F		No	ClinGen ExAC gnomAD
CA409951771 rs1163282312	62	L>F		No	ClinGen gnomAD
CA409951715 rs1344877314	66	Y>*		No	ClinGen TOPMed
CA409951709 rs1428929555	67	P>A		No	ClinGen TOPMed
CA409951698 rs1180445248	68	C>S		No	ClinGen gnomAD
rs767398450 CA10026046	68	C>S		No	ClinGen ExAC gnomAD
CA10026045 rs138957098	69	S>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1323712341 CA409951657	71	F>L		No	ClinGen TOPMed gnomAD
CA10026044 rs774480663	72	I>T		No	ClinGen ExAC gnomAD
rs1043292705 CA320548295	72	I>V		No	ClinGen TOPMed
rs139461009 CA10026043	74	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA10026042 rs763206563	75	I>M		No	ClinGen ExAC gnomAD
rs1354344970 CA409951608	75	I>V		No	ClinGen gnomAD
rs1238975773 CA409951545	80	V>I		No	ClinGen gnomAD
CA10026022 rs200021987	81	A>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA10026023 rs200021987	81	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1435305097 CA409951421	83	L>R		No	ClinGen gnomAD
rs765587257 CA320547344	85	S>T		No	ClinGen Ensembl
CA320547342 rs953515284	86	F>L		No	ClinGen TOPMed
CA10026021 rs777122150	87	V>I		No	ClinGen ExAC gnomAD
CA10026019 rs747517912	88	M>I		No	ClinGen ExAC gnomAD
CA10026020 rs78317549	88	M>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs775909905 CA10026018	89	N>D		No	ClinGen ExAC gnomAD
CA10026017 rs187341087	89	N>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA409951340 rs1377320295	90	S>*		No	ClinGen TOPMed
rs370832635 CA10026016	91	G>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA10026015 rs777266146	92	V>A		No	ClinGen ExAC TOPMed gnomAD
CA320547311 rs1015195128	93	W>C		No	ClinGen TOPMed
rs755701822 CA10026014	96	V>F		No	ClinGen ExAC gnomAD
rs755701822 CA409951267	96	V>I		No	ClinGen ExAC gnomAD
rs1190445481 CA409951253	97	G>D		No	ClinGen TOPMed gnomAD
rs551566053 CA10026012	98	C>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA409951237 rs1217380951	98	C>W		No	ClinGen gnomAD
CA409951226 rs1488006578	99	A>V		No	ClinGen gnomAD
CA10026010 rs751396324	100	K>E		No	ClinGen ExAC gnomAD
CA409951212 rs1313366467	100	K>N		No	ClinGen gnomAD
rs766188436 CA10026009	101	L>F		No	ClinGen ExAC TOPMed gnomAD
rs910015439 CA409951186	102	W>*		No	ClinGen gnomAD
rs910015439 CA320547281	102	W>C		No	ClinGen gnomAD
CA409951197 rs1217887709	102	W>R		No	ClinGen gnomAD
CA409951180 rs1279736473	103	N>D		No	ClinGen gnomAD
rs758362425 CA10026008	104	E>K		No	ClinGen ExAC gnomAD
CA409951149 rs1461057359	105	W>R		No	ClinGen TOPMed
rs562774244 CA10026007	106	C>R		No	ClinGen 1000Genomes ExAC gnomAD
CA10026006 rs183446739	106	C>Y		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10026004 rs777034165	107	R>G		No	ClinGen ExAC gnomAD
rs143749424 CA10026003	108	T>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1468065603 CA409951094	109	T>A		No	ClinGen gnomAD
CA409951096 rs1468065603	109	T>P		No	ClinGen gnomAD
TCGA novel	110	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA409951059 rs1569143129	111	T>I		No	ClinGen Ensembl
CA409951055 rs1348602777	112	T>A		No	ClinGen gnomAD
rs780526161 CA320547236	113	H>Y		No	ClinGen Ensembl
CA409951028 rs1186500201	114	L>Q		No	ClinGen TOPMed
rs1290815110 CA409951012	116	S>A		No	ClinGen TOPMed gnomAD
rs1194672826 CA409950991	117	T>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1477651901 CA409950968	119	A>G		No	ClinGen gnomAD
rs1601187434 CA409950945	121	C>Y		No	ClinGen Ensembl
rs1259739472 CA409950935	122	V>L		No	ClinGen gnomAD
CA10026001 rs149520065	124	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA409950908 rs1208413855	124	Y>H		No	ClinGen gnomAD
rs746383934 CA10025999	125	H>P		No	ClinGen ExAC TOPMed gnomAD
CA10026000 rs746383934	125	H>R		No	ClinGen ExAC TOPMed gnomAD
CA10025996 rs747781442	129	N>K		No	ClinGen ExAC gnomAD
rs200278874 CA10025997	129	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs780777266 CA10025995	131	S>L		No	ClinGen ExAC TOPMed gnomAD
rs138014655 CA10025975	136	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA409950286 rs1356377477	136	Q>R		No	ClinGen TOPMed
CA409950248 rs1291756915	139	C>R		No	ClinGen TOPMed
CA10025973 rs200670808	140	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs776210231 CA10025972	141	V>A		No	ClinGen ExAC gnomAD
rs1458427010 CA409950219	141	V>I		No	ClinGen gnomAD
rs145581162 CA10025971	143	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs1178368013 CA409950176	144	D>E		No	ClinGen gnomAD
CA10025970 rs746733243	144	D>G		No	ClinGen ExAC gnomAD
CA409950184 rs1177683273	144	D>N		No	ClinGen TOPMed
CA409950182 rs1177683273	144	D>Y		No	ClinGen TOPMed
rs1436434533 CA409950171	145	Q>E		No	ClinGen gnomAD
rs1247908958 CA409950163	145	Q>L		No	ClinGen gnomAD
rs1488641517 CA409950145	146	Q>H		No	ClinGen TOPMed gnomAD
CA409950136 rs1290360110	147	Y>C		No	ClinGen gnomAD
CA409950125 rs1219681663	148	Q>*		No	ClinGen gnomAD
CA10025969 rs779709634	151	E>G		No	ClinGen ExAC gnomAD
CA10025968 rs772032936	152	K>E		No	ClinGen ExAC gnomAD
rs754072332 CA320545645	154	F>L		No	ClinGen Ensembl
rs775255191 CA10025948	155	G>D		No	ClinGen ExAC gnomAD
rs899535833 CA320545631	161	N>D		No	ClinGen TOPMed
rs771873690 CA10025947	162	M>T		No	ClinGen ExAC gnomAD
rs745617678 CA10025946	163	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA10025945 rs770931237	164	I>L		No	ClinGen ExAC TOPMed gnomAD
CA10025944 rs770931237	164	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1352941557 CA409949903	165	T>I		No	ClinGen TOPMed
CA10025942 rs375585989	166	I>S		No	ClinGen ESP ExAC gnomAD
CA10025943 rs8131611 RCV000887207 VAR_054014	166	I>V		No	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1258190748 CA409949888	168	T>K		No	ClinGen gnomAD
CA409949887 rs1258190748	168	T>R		No	ClinGen gnomAD
TCGA novel	169	C>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs756269433 CA10025941	169	C>S		No	ClinGen ExAC TOPMed gnomAD
CA10025940 rs372682958	170	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
CA10025937 rs751864587	174	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed
CA10025935 rs145022066	175	Y>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA10025936 rs766787420	175	Y>H		No	ClinGen ExAC TOPMed gnomAD
CA409949829 rs1418412514	177	T>I		No	ClinGen TOPMed
CA10025934 rs750980554	177	T>P		No	ClinGen ExAC gnomAD
CA10025931 rs370704900	182	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1173841916 CA409949781	185	P>S		No	ClinGen gnomAD
CA409949769 rs1466856022	187	P>S		No	ClinGen TOPMed gnomAD
CA10025929 rs767210983	188	F>C		No	ClinGen ExAC TOPMed gnomAD
rs1474160664 CA409949743	191	A>V		No	ClinGen gnomAD
rs1416018464 CA409949739	192	L>V		No	ClinGen TOPMed gnomAD
TCGA novel	194	T>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	195	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10025928 rs759272360	197	F>L		No	ClinGen ExAC TOPMed gnomAD
CA10025926 rs1375980395	199	D>A		No	ClinGen TOPMed
rs774270699 CA320545461	200	S>L		No	ClinGen ExAC TOPMed gnomAD
CA10025925 rs774270699	200	S>W		No	ClinGen ExAC TOPMed gnomAD
rs113955862 CA320545448	201	A>V		No	ClinGen TOPMed gnomAD
CA409949666 rs1458338456	202	C>W		No	ClinGen gnomAD
rs773155392 CA10025922	203	C>R		No	ClinGen ExAC TOPMed gnomAD
rs769653352 CA10025921	203	C>Y		No	ClinGen ExAC gnomAD
rs748196540 CA10025920	204	P>S		No	ClinGen ExAC gnomAD
CA409949649 rs1470018073	205	L>F		No	ClinGen TOPMed
rs1214633979 CA409949645	206	L>Q		No	ClinGen TOPMed
TCGA novel	207	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1238015714 CA409949640	207	E>K		No	ClinGen TOPMed
CA10025918 rs755180823	209	P>L		No	ClinGen ExAC gnomAD
rs1333723523 CA409949617	210	N>S		No	ClinGen gnomAD
rs202176293 CA10025916	211	I>T		No	ClinGen 1000Genomes ExAC gnomAD
CA409949613 rs1206083719	211	I>V		No	ClinGen Ensembl
CA10025915 rs200756272	212	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA409949596 rs752793382	213	H>Q		No	ClinGen ExAC TOPMed gnomAD
rs970810152 CA320545325	214	D>N		No	ClinGen TOPMed gnomAD
rs148120925 CA10025911	217	A>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs757707960 CA10025912	217	A>T		No	ClinGen ExAC gnomAD
CA320545305 rs879815069	218	A>G		No	ClinGen TOPMed gnomAD
CA10025910 rs767190360	218	A>T		No	ClinGen ExAC TOPMed gnomAD
CA409949565 rs1180203920	219	V>F		No	ClinGen gnomAD
rs768118227 CA320544612	221	S>N		No	ClinGen Ensembl
rs1403740620 CA409949537	222	Y>N		No	ClinGen gnomAD
CA409949497 rs1236485570	227	K>E		No	ClinGen TOPMed
rs143701237 CA10025877	227	K>N		No	ClinGen ESP ExAC gnomAD
CA10025876 rs746131426	228	I>T		No	ClinGen ExAC
rs779327198 COSM3423958 CA10025875	229	P>L	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs779327198 CA409949481	229	P>Q		No	ClinGen ExAC TOPMed gnomAD
rs1304213656 CA409949485	229	P>T		No	ClinGen TOPMed
rs1359542733 CA409949473	231	I>V		No	ClinGen TOPMed gnomAD
TCGA novel	233	Y>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1415995312 CA409949458	233	Y>C		No	ClinGen gnomAD
CA409949445 rs1430192678	235	C>R		No	ClinGen gnomAD
rs756696002 CA10025871	237	T>S		No	ClinGen ExAC TOPMed gnomAD
CA320544576 rs890938558	238	D>G		No	ClinGen gnomAD
CA409949407 rs1194549531	240	M>I		No	ClinGen gnomAD
CA409949380 rs1213399019	244	L>V		No	ClinGen TOPMed
CA10025869 rs779492117	247	V>A		No	ClinGen ExAC gnomAD
CA10025870 rs779492117	247	V>G		No	ClinGen ExAC gnomAD
CA10025868 rs758066017	249	A>T		No	ClinGen ExAC gnomAD
CA637819566 rs1428101436	250	F>*		No	ClinGen TOPMed gnomAD
CA409949306 rs1222485756	255	S>F		No	ClinGen gnomAD
rs1339157784 CA409949291	258	S>G		No	ClinGen Ensembl
CA409949289 rs1029466081	258	S>N		No	ClinGen TOPMed gnomAD
CA320544537 rs1029466081	258	S>T		No	ClinGen TOPMed gnomAD
CA10025867 rs556876616	259	L>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs761548890 CA409949271	261	G>C		No	ClinGen ExAC TOPMed gnomAD
rs761548890 CA10025865	261	G>R		No	ClinGen ExAC TOPMed gnomAD
rs1417952964 CA409949257	263	V>A		No	ClinGen TOPMed
rs537846197 CA10025863	263	V>I		No	ClinGen 1000Genomes ExAC gnomAD
rs1202537922 CA409949231	265	N>S		No	ClinGen TOPMed
TCGA novel	267	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	269	S>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA409949178 rs1484223212	272	I>M		No	ClinGen gnomAD
TCGA novel	274	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	275	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs34970037 CA10025838 RCV000907532	276	L>F		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1441958551 CA409949134	279	T>A		No	ClinGen gnomAD
CA409949094 rs766653960	284	S>I		No	ClinGen ExAC gnomAD
CA10025837 rs766653960	284	S>N		No	ClinGen ExAC gnomAD
CA409949090 rs1187169158	285	N>D		No	ClinGen TOPMed
rs1195991315 CA409949087	285	N>S		No	ClinGen gnomAD
rs763327980 CA10025836	286	I>V		No	ClinGen ExAC gnomAD

No associated diseases with O95456

No regional properties for O95456

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for O95456

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Endoplasmic reticulum
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

7 GO annotations of cellular component

Name	Definition
chaperone complex	A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
Golgi apparatus	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name	Definition
molecular adaptor activity	The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.
proteasome binding	Binding to a proteasome, a large multisubunit protein complex that catalyzes protein degradation.

3 GO annotations of biological process

Name	Definition
cerebellar granule cell precursor proliferation	The multiplication or reproduction of neuroblasts that will give rise to granule cells. A granule cell is a glutamatergic interneuron found in the cerebellar cortex.
chaperone-mediated protein complex assembly	The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex.
proteasome core complex assembly	The aggregation, arrangement and bonding together of a mature, active 20S proteasome core particle complex that does not contain any regulatory particles.

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q0P5F2	PSMG1	Proteasome assembly chaperone 1	Bos taurus (Bovine)	PR
Q9JK23	Psmg1	Proteasome assembly chaperone 1	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MAATFFGEVV	KAPCRAGTED	EEEEEEGRRE	TPEDREVRLQ	LARKREVRLL	RRQTKTSLEV
70	80	90	100	110	120
SLLEKYPCSK	FIIAIGNNAV	AFLSSFVMNS	GVWEEVGCAK	LWNEWCRTTD	TTHLSSTEAF
130	140	150	160	170	180
CVFYHLKSNP	SVFLCQCSCY	VAEDQQYQWL	EKVFGSCPRK	NMQITILTCR	HVTDYKTSES
190	200	210	220	230	240
TGSLPSPFLR	ALKTQNFKDS	ACCPLLEQPN	IVHDLPAAVL	SYCQVWKIPA	ILYLCYTDVM
250	260	270	280
KLDLITVEAF	KPILSTRSLK	GLVKNIPQST	EILKKLMTTN	EIQSNIYT