AiPD: Autoinhibited Protein Database

O95150

Gene name	TNFSF15 (TL1, VEGI)
Protein name	Tumor necrosis factor ligand superfamily member 15
Names	TNF ligand-related molecule 1, Vascular endothelial cell growth inhibitor
Species	Homo sapiens (Human)
KEGG Pathway	hsa:9966
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-203 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-203 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

8 structures for O95150

Entry ID	Method	Resolution	Chain	Position	Source
2O0O	X-ray	300 A	A/B/C	72-251	PDB
2QE3	X-ray	250 A	A	72-251	PDB
2RE9	X-ray	210 A	A/B/C	72-251	PDB
2RJK	X-ray	230 A	A	72-251	PDB
2RJL	X-ray	205 A	A	72-251	PDB
3K51	X-ray	245 A	A	72-251	PDB
3MI8	X-ray	295 A	A	72-251	PDB
AF-O95150-F1	Predicted				AlphaFoldDB

195 variants for O95150

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1564348710 CA374687431	2	A>P		No	ClinGen Ensembl
CA5207096 rs371110841	3	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA5207095 rs765222060	6	G>E		No	ClinGen ExAC gnomAD
rs1357593846 CA374687398	7	L>P		No	ClinGen gnomAD
rs757409599 CA5207094	8	S>N		No	ClinGen ExAC gnomAD
rs140689831 CA374687382	9	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA374687386 rs1399648493	9	F>S		No	ClinGen gnomAD
CA5207092 rs764654587	10	G>R		No	ClinGen ExAC gnomAD
CA5207090 rs775935352	11	E>D		No	ClinGen ExAC gnomAD
CA5207091 rs761282953	11	E>K		No	ClinGen ExAC TOPMed gnomAD
CA374687370 rs1587903804	12	T>P		No	ClinGen Ensembl
rs1218308722 CA374687364	13	A>T		No	ClinGen TOPMed
CA5207088 rs369441005 CA5207087	14	S>R		No	ClinGen ExAC TOPMed gnomAD
rs767994309 CA5207089	14	S>R		No	ClinGen ExAC gnomAD
rs562601626 CA5207086	16	E>K		No	ClinGen 1000Genomes ExAC gnomAD
CA374687333 rs1587903793	17	M>I		No	ClinGen Ensembl
rs1047533515 CA198901216	20	E>D		No	ClinGen Ensembl
CA198901217 rs56129146	20	E>K		No	ClinGen Ensembl
CA5207085 rs146813484	21	H>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	21	H>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA374687306 rs768523743	22	G>C		No	ClinGen ExAC TOPMed gnomAD
CA5207082 rs576932402	22	G>D		No	ClinGen 1000Genomes ExAC gnomAD
CA5207083 rs768523743	22	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1400935280 CA374687287	25	R>G		No	ClinGen TOPMed
rs150191342 RCV000904737 CA5207080	25	R>K		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs150191342 CA374687285	25	R>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA198901215 rs368232426	26	P>L		No	ClinGen ESP TOPMed
CA374687279 rs1363558322	26	P>S		No	ClinGen TOPMed
rs746059555 COSM1582778 CA5207079	27	K>E	stomach [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA198901214 rs750605115	28	A>T		No	ClinGen Ensembl
CA374687261 rs1279043315	29	R>K		No	ClinGen TOPMed
CA5207078 rs779239225	30	S>N		No	ClinGen ExAC gnomAD
rs757455616 CA5207077	31	S>R		No	ClinGen ExAC gnomAD
rs140925489 CA5207076	32	S>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs753318529 CA5207073	33	A>S		No	ClinGen ExAC TOPMed gnomAD
CA5207074 rs753318529	33	A>T		No	ClinGen ExAC TOPMed gnomAD
rs55683440 CA5207072	34	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA5207071 rs201981566	34	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs201981566 CA198901213	34	R>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1233763127 CA374687220	36	A>T		No	ClinGen gnomAD
rs772707672 CA5207070	36	A>V		No	ClinGen ExAC gnomAD
rs377131025 CA5207069	37	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA374687214 rs377131025	37	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1160125356 CA374687182	42	V>L		No	ClinGen TOPMed
rs142809540 CA198901212	43	L>W		No	ClinGen ESP
CA374687163 rs1587903714	45	P>S		No	ClinGen Ensembl
CA374687153 rs1365054184	46	F>L		No	ClinGen TOPMed gnomAD
rs1320756540 CA374687147	47	L>P		No	ClinGen gnomAD
rs866462140 CA198901210	48	A>T		No	ClinGen Ensembl
rs761388330 CA5207067	48	A>V		No	ClinGen ExAC TOPMed gnomAD
rs776054186 CA5207066	49	G>E		No	ClinGen ExAC gnomAD
CA374687133 rs1392705533	50	L>H		No	ClinGen TOPMed
CA5207065 rs768222774	51	T>I		No	ClinGen ExAC gnomAD
CA198901208 rs961818106	56	V>L		No	ClinGen TOPMed
CA5207062 rs771826971	57	S>R		No	ClinGen ExAC gnomAD
rs527825986 CA198901207	58	Q>R		No	ClinGen Ensembl
CA374687078 rs745637627	59	L>P		No	ClinGen ExAC TOPMed gnomAD
CA5207061 rs745637627	59	L>R		No	ClinGen ExAC TOPMed gnomAD
CA198901206 rs1028941301	60	R>Q		No	ClinGen TOPMed gnomAD
CA5207060 rs554137268	60	R>W		No	ClinGen 1000Genomes ExAC gnomAD
rs1271897082 CA374687071	61	A>S		No	ClinGen gnomAD
CA374687066 rs1294409455	62	Q>E		No	ClinGen TOPMed
rs1294409455 CA374687067	62	Q>K		No	ClinGen TOPMed
CA374687063 rs749472080	62	Q>P		No	ClinGen ExAC TOPMed gnomAD
CA5207058 rs749472080	62	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA5207057 rs777991000	63	G>E		No	ClinGen ExAC gnomAD
rs756319889 CA5207056	65	A>V		No	ClinGen ExAC
CA374687037 rs1374591489	66	C>F		No	ClinGen TOPMed gnomAD
CA374687039 rs1374591489	66	C>Y		No	ClinGen TOPMed gnomAD
rs781774264 CA5207054	67	V>A		No	ClinGen ExAC gnomAD
rs537486487 CA5207055	67	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA374687019 rs1587903647	69	F>Y		No	ClinGen Ensembl
rs1290124561 CA374687012	70	Q>*		No	ClinGen gnomAD
TCGA novel	72	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA374686981 rs1240942553	72	L>P		No	ClinGen gnomAD
CA5207033 rs780453763	73	K>E		No	ClinGen ExAC gnomAD
CA5207032 rs201039485	76	E>K		No	ClinGen 1000Genomes ExAC gnomAD
rs753461731 CA5207031	79	P>A		No	ClinGen ExAC TOPMed gnomAD
CA374686921 rs1206745818	81	H>R		No	ClinGen gnomAD
CA374686910 rs1446425593	82	Q>H		No	ClinGen gnomAD
rs1290489216 CA374686909	83	Q>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1461120016 CA374686876	85	Y>*		No	ClinGen gnomAD
CA374686864 rs1254888631	87	P>H		No	ClinGen TOPMed gnomAD
rs768751032 CA5207001	88	L>F		No	ClinGen ExAC gnomAD
rs747024209 CA5207000	88	L>P		No	ClinGen ExAC gnomAD
rs1468026647 CA374686858	89	R>G		No	ClinGen gnomAD
rs1428574713 CA374686855	89	R>I		No	ClinGen gnomAD
CA374686856 rs1428574713	89	R>T		No	ClinGen gnomAD
CA374686849 rs1159774940	90	A>E		No	ClinGen gnomAD
CA5206999 rs775666236	91	D>G		No	ClinGen ExAC TOPMed gnomAD
CA198899766 rs866972093	92	G>E		No	ClinGen Ensembl
rs746375852 CA5206997	92	G>R		No	ClinGen ExAC TOPMed gnomAD
rs1238253306 CA374686819	95	P>T		No	ClinGen gnomAD
CA5206995 rs757672135	96	R>S		No	ClinGen ExAC TOPMed gnomAD
rs747809936 CA5206994	97	A>S		No	ClinGen ExAC gnomAD
rs550636247 CA5206970	104	Q>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5206968 rs200936418	104	Q>H		No	ClinGen 1000Genomes ExAC gnomAD
rs550636247 CA5206969	104	Q>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs565550412 CA5206966	106	P>R		No	ClinGen 1000Genomes ExAC gnomAD
rs763957233 CA5206964	107	T>I		No	ClinGen ExAC gnomAD
CA5206965 rs753523598	107	T>P		No	ClinGen ExAC TOPMed gnomAD
CA5206962 rs753019245	108	Q>P		No	ClinGen ExAC gnomAD
rs753019245 CA5206963	108	Q>R		No	ClinGen ExAC gnomAD
CA374686563 rs372685008	109	H>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs201333233 CA5206958	109	H>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs201333233 CA5206959	109	H>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs372685008 CA5206960	109	H>Y		No	ClinGen ESP ExAC TOPMed gnomAD
RCV000947201 CA5206957 VAR_043130 rs16931745	110	F>L		No	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA374686548 rs1169435031	111	K>R		No	ClinGen gnomAD
rs773380295 CA5206956	112	N>K		No	ClinGen ExAC TOPMed gnomAD
rs770252535 CA5206955	113	Q>L		No	ClinGen ExAC gnomAD
CA5206954 rs746621637	114	F>Y		No	ClinGen ExAC gnomAD
CA5206953 rs779892512	116	A>T		No	ClinGen ExAC
CA5206952 rs771882145	117	L>P		No	ClinGen ExAC gnomAD
rs918842271 CA198899603	125	L>Q		No	ClinGen gnomAD
CA5206948 rs753883025	126	A>G		No	ClinGen ExAC TOPMed gnomAD
rs757078623 CA5206949	126	A>T		No	ClinGen ExAC gnomAD
rs1197127247 CA374686444	127	F>S		No	ClinGen gnomAD
rs752880973 CA5206945	131	R>*		No	ClinGen ExAC gnomAD
CA5206944 rs370931148	131	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1403226813 CA374686413	132	M>L		No	ClinGen TOPMed gnomAD
rs1403226813 CA374686414	132	M>V		No	ClinGen TOPMed gnomAD
rs192783899 CA374686401 CA374686400	133	N>K		No	ClinGen 1000Genomes TOPMed gnomAD
rs888774101 CA198899600	133	N>S		No	ClinGen TOPMed
CA198899598 rs749946059	135	T>A		No	ClinGen Ensembl
CA198899596 rs867957370	138	F>L		No	ClinGen Ensembl
rs1043903510 CA198899595	141	I>N		No	ClinGen TOPMed
CA374686336 rs1477177470	143	E>V		No	ClinGen Ensembl
CA5206942 rs368084272 COSM201943	144	S>L	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA374686327 rs1332192451	145	G>R		No	ClinGen TOPMed
rs763364067 CA5206940	155	F>L		No	ClinGen ExAC gnomAD
CA374686255 rs1192129602	155	F>Y		No	ClinGen gnomAD
CA5206939 rs370283022	156	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA
CA5206938 rs139705441	156	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs1564344186 CA374686235	158	M>I		No	ClinGen Ensembl
CA5206936 rs777159050	158	M>L		No	ClinGen ExAC gnomAD
CA374686232 rs1251829228	159	T>A		No	ClinGen gnomAD
CA374686228 rs771795926	159	T>I		No	ClinGen ExAC TOPMed gnomAD
rs771795926 CA5206935	159	T>N		No	ClinGen ExAC TOPMed gnomAD
CA374686226 rs1249364761	160	S>P		No	ClinGen TOPMed gnomAD
CA5206933 rs773998277	161	E>Q		No	ClinGen ExAC gnomAD
CA198899593 rs764896114	162	C>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs200996697 CA5206931	163	S>R		No	ClinGen 1000Genomes ExAC gnomAD
rs557041991 CA374686161	169	G>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5206929 rs756034226	169	G>S		No	ClinGen ExAC TOPMed gnomAD
CA5206928 rs557041991	169	G>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1334265183 CA374686159 COSM1104430	170	R>*	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs144487361 CA374686157	170	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs144487361 CA5206927	170	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA5206926 rs755125917	171	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA374686151 rs1408692404	172	N>D		No	ClinGen gnomAD
rs867213148 CA198899591	176	S>F		No	ClinGen Ensembl
CA374686120 rs1335329920	176	S>P		No	ClinGen gnomAD
CA374686105 rs1469676476	178	T>S		No	ClinGen TOPMed gnomAD
CA5206923 rs149700202	182	T>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs149700202 CA5206924	182	T>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs928228400 CA198899590	183	K>R		No	ClinGen TOPMed gnomAD
TCGA novel	184	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1468135390 CA374686063	185	T>R		No	ClinGen gnomAD
rs750502102 CA5206922	186	D>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
TCGA novel	186	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1218000940 CA374686051	187	S>N		No	ClinGen gnomAD
rs764624230 CA5206919	188	Y>*		No	ClinGen ExAC gnomAD
rs762427267 CA5206920	188	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs765727909 CA5206921	188	Y>D		No	ClinGen ExAC gnomAD
CA198899589 rs371091768	191	P>S		No	ClinGen ESP TOPMed gnomAD
rs371091768 CA374686026	191	P>T		No	ClinGen ESP TOPMed gnomAD
CA374686017 rs1225587127	192	T>I		No	ClinGen gnomAD
CA198899588 rs893642296	194	L>F		No	ClinGen Ensembl
TCGA novel	194	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5206916 rs774192671	196	M>T		No	ClinGen ExAC
rs1587897491 CA374685984	197	G>V		No	ClinGen Ensembl
rs150498686 CA5206910	203	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA5206909 rs754824293	204	V>A		No	ClinGen ExAC gnomAD
rs747201293 CA5206908	205	G>S		No	ClinGen ExAC gnomAD
rs1389685315 CA374685933	205	G>V		No	ClinGen gnomAD
TCGA novel	208	W>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs895341787 CA198899587	213	Y>*		No	ClinGen Ensembl
CA5206906 rs758572471	215	G>R	Variant assessed as Somatic; 4.62e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1298405818 CA374685850	217	M>R		No	ClinGen gnomAD
CA374685817 rs1463136556	221	Q>H		No	ClinGen gnomAD
CA374685809 rs1383002485	222	E>D		No	ClinGen gnomAD
CA374685804 rs1182824443	223	G>E		No	ClinGen gnomAD
CA5206903 rs138476552	227	M>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA374685760 rs754459102	229	N>K		No	ClinGen ExAC TOPMed gnomAD
CA198899585 rs889534030	230	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA374685742 rs1445362541	232	D>G		No	ClinGen gnomAD
rs1283563027 CA374685737	233	I>V		No	ClinGen gnomAD
CA198899583 rs7027251	240	K>*		No	ClinGen Ensembl
rs1223310365 COSM3847459 CA374685652	245	F>L	breast [Cosmic]	No	ClinGen cosmic curated gnomAD
rs764534409 CA5206901	248	A>D		No	ClinGen ExAC gnomAD
TCGA novel	248	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs901641124 CA198899582	248	A>T		No	ClinGen TOPMed
rs1177866256 CA374685611	251	L>V		No	ClinGen TOPMed
CA374685607 rs1245749056	252	L>Q		No	ClinGen gnomAD

No associated diseases with O95150

1 regional properties for O95150

Type	Name	Position	InterPro Accession
domain	Tumour necrosis factor domain	95 - 251	IPR006052

Functions

		Description
EC Number
Subcellular Localization	Membrane ; Single-pass type II membrane protein ;
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
extracellular space	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of plasma membrane	The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name	Definition
cytokine activity	The activity of a soluble extracellular gene product that interacts with a receptor to effect a change in the activity of the receptor to control the survival, growth, differentiation and effector function of tissues and cells.
signaling receptor binding	Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
tumor necrosis factor receptor binding	Binding to a tumor necrosis factor receptor.

5 GO annotations of biological process

Name	Definition
activation of cysteine-type endopeptidase activity involved in apoptotic process	Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
activation of NF-kappaB-inducing kinase activity	The stimulation of the activity of NF-kappaB-inducing kinase through phosphorylation at specific residues.
apoptotic process	A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
immune response	Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q8K3Y7	Tnfsf15	Tumor necrosis factor ligand superfamily member 15	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MAEDLGLSFG	ETASVEMLPE	HGSCRPKARS	SSARWALTCC	LVLLPFLAGL	TTYLLVSQLR
70	80	90	100	110	120
AQGEACVQFQ	ALKGQEFAPS	HQQVYAPLRA	DGDKPRAHLT	VVRQTPTQHF	KNQFPALHWE
130	140	150	160	170	180
HELGLAFTKN	RMNYTNKFLL	IPESGDYFIY	SQVTFRGMTS	ECSEIRQAGR	PNKPDSITVV
190	200	210	220	230	240
ITKVTDSYPE	PTQLLMGTKS	VCEVGSNWFQ	PIYLGAMFSL	QEGDKLMVNV	SDISLVDYTK
250
EDKTFFGAFL	L