O94956
PR
Gene name |
SLCO2B1 |
Protein name |
Solute carrier organic anion transporter family member 2B1 |
Names |
Organic anion transporter B, OATP-B, Organic anion transporter polypeptide-related protein 2, OATP-RP2, OATPRP2, Organic anion transporting polypeptide 2B1, OATP2B1, Solute carrier family 21 member 9 |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:11309 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O94956
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O94956-F1 | Predicted | AlphaFoldDB |
5 variants for O94956
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
VAR_036412 rs865987804 CA224644102 COSM1704396 |
77 | E>K | skin a breast cancer sample; somatic mutation [Cosmic, UniProt] | No |
ClinGen cosmic curated UniProt Ensembl dbSNP |
|
COSM2153363 VAR_053675 rs35199625 CA6188139 |
201 | V>M | central_nervous_system [Cosmic] | No |
ClinGen cosmic curated UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
rs12422149 VAR_053676 CA6188232 RCV002291808 |
312 | R>Q | No |
ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs1621378 CA224627402 VAR_053677 |
392 | I>T | No |
ClinGen UniProt 1000Genomes ESP ExAC dbSNP gnomAD |
|
|
rs2306168 CA6188400 VAR_020294 |
486 | S>F | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
No associated diseases with O94956
1 regional properties for O94956
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Kazal domain | 483 - 543 | IPR002350 |
Functions
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| bile acid transmembrane transporter activity | Enables the transfer of bile acid from one side of a membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. |
| organic anion transmembrane transporter activity | Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. |
| sodium-independent organic anion transmembrane transporter activity | Enables the transfer of organic anions from one side of a membrane to the other, in a sodium independent manner. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| bile acid and bile salt transport | The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| heme catabolic process | The chemical reactions and pathways resulting in the breakdown of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. |
| organic anion transport | The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. |
| sodium-independent organic anion transport | The directed, sodium-independent, movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| transmembrane transport | The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. |
| transport across blood-brain barrier | The directed movement of substances (e.g. macromolecules, small molecules, ions) through the blood-brain barrier. |
| xenobiotic metabolic process | The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9NPD5 | SLCO1B3 | Solute carrier organic anion transporter family member 1B3 | Homo sapiens (Human) | PR |
| Q9JJL3 | Slco1b2 | Solute carrier organic anion transporter family member 1B2 | Mus musculus (Mouse) | PR |
| Q9QZX8 | Slco1b2 | Solute carrier organic anion transporter family member 1B2 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGPRIGPAGE | VPQVPDKETK | ATMGTENTPG | GKASPDPQDV | RPSVFHNIKL | FVLCHSLLQL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AQLMISGYLK | SSISTVEKRF | GLSSQTSGLL | ASFNEVGNTA | LIVFVSYFGS | RVHRPRMIGY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GAILVALAGL | LMTLPHFISE | PYRYDNTSPE | DMPQDFKASL | CLPTTSAPAS | APSNGNCSSY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TETQHLSVVG | IMFVAQTLLG | VGGVPIQPFG | ISYIDDFAHN | SNSPLYLGIL | FAVTMMGPGL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AFGLGSLMLR | LYVDINQMPE | GGISLTIKDP | RWVGAWWLGF | LIAAGAVALA | AIPYFFFPKE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| MPKEKRELQF | RRKVLAVTDS | PARKGKDSPS | KQSPGESTKK | QDGLVQIAPN | LTVIQFIKVF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PRVLLQTLRH | PIFLLVVLSQ | VCLSSMAAGM | AIFLPKFLER | QFSITASYAN | LLIGCLSFPS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VIVGIVVGGV | LVKRLHLGPV | GCGALCLLGM | LLCLFFSLPL | FFIGCSSHQI | AGITHQTSAH |
| 490 | 500 | 510 | 520 | 530 | 540 |
| PGLELSPSCM | EACSCPLDGF | NPVCDPSTRV | EYITPCHAGC | SSWVVQDALD | NSQVFYTNCS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| CVVEGNPVLA | GSCDSTCSHL | VVPFLLLVSL | GSALACLTHT | PSFMLILRGV | KKEDKTLAVG |
| 610 | 620 | 630 | 640 | 650 | 660 |
| IQFMFLRILA | WMPSPVIHGS | AIDTTCVHWA | LSCGRRAVCR | YYNNDLLRNR | FIGLQFFFKT |
| 670 | 680 | 690 | 700 | ||
| GSVICFALVL | AVLRQQDKEA | RTKESRSSPA | VEQQLLVSGP | GKKPEDSRV |