O88941

PR
Gene name
Mogs (Gcs1)
Protein name
Mannosyl-oligosaccharide glucosidase
Names
Glycoprotein-processing glucosidase I
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:78947
EC number
3.2.1.106: Glycosidases, ie enzymes hydrolyzing O- and S-glycosyl compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-62 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O88941

Entry ID Method Resolution Chain Position Source
AF-O88941-F1 Predicted AlphaFoldDB

No variants for O88941

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O88941

No associated diseases with O88941

3 regional properties for O88941

Type Name Position InterPro Accession
domain GINS subunit, domain A 50 - 126 IPR021151
domain DNA replication complex GINS protein SLD5, C-terminal 165 - 223 IPR031633
domain GINS complex protein Sld5, alpha-helical domain 26 - 146 IPR038749

Functions

Description
EC Number 3.2.1.106 Glycosidases, ie enzymes hydrolyzing O- and S-glycosyl compounds
Subcellular Localization
  • Endoplasmic reticulum membrane ; Single-pass type II membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

1 GO annotations of molecular function

Name Definition
Glc3Man9GlcNAc2 oligosaccharide glucosidase activity Catalysis of the exohydrolysis of the non-reducing terminal glucose residue in the mannosyl-oligosaccharide Glc(3)Man(9)GlcNAc(2).

2 GO annotations of biological process

Name Definition
oligosaccharide metabolic process The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages.
protein N-linked glycosylation A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
F4HTM3 GCS1 Mannosyl-oligosaccharide glucosidase GCS1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MARGERRRRA AAAEGARPLE RARGAGRRDG RAGGARGSAG GAALAVVVLA LAFGLSGRWV
70 80 90 100 110 120
LAWLGVRRAL TLHPAPSALP PDSSSPAVAP EFFWGTYRPH VYFGMKTRSP KPLLTGLMWA
130 140 150 160 170 180
QQGATPGTPP KLRHTCEQGD GVGPYGWEFH DGLSFGRQHI YDGALRLTTE FVKRSGGHHG
190 200 210 220 230 240
GDWSWRVTVE PQASGTPSFP LVSLFFYVVT DGQEVLLPEV GAKGQLKFIS GHTSELGDFR
250 260 270 280 290 300
LTLLPPTTPG DTVPKHGSYN VFWSSNPGLP LLTDMVKSHL NSWFHHRPPG ASPERYLGLP
310 320 330 340 350 360
GSLKWEERGP SGQGQFLVQQ VTLKAPFSVE FVFESGSART GRDQASEQLV GGQLTRALES
370 380 390 400 410 420
HAAAFKERFE RTFQLKEKGL SPEEQALGQV ALSGLLGGIG YFYGQGLVLP DTGMEGSEQK
430 440 450 460 470 480
MDPSLFPPVP LFSGVPSRSF FPRGFLWDEG FHQLVVQRWD PHLTREALGH WLGLLNADGW
490 500 510 520 530 540
IGREQILGDE ARARVPPEFL VQRAAHANPP TLLLPVIHML EGRAPEDLAF LRRAFPRLHA
550 560 570 580 590 600
WFSWLHQSQA GPVPLSYRWR GRDLALPTLL NPKTLPSGLD DYPRASHPSA AERHLDLRCW
610 620 630 640 650 660
VTLGARVLSQ LAEELGETEA AAELGPLAAS LEAAGSLDEL HWAPELGVFA DFGNHTKAVQ
670 680 690 700 710 720
LKSRPPQGLV RVVGRPPARL QYVDALGYVS LFPLLLQLLE PSSPRLGPLL DVLADSRHLW
730 740 750 760 770 780
SPFGLRSLSA SSLFYKQRNT EHDPPYWRGA VWLNINYLAL GALHHYGRVE GPHKVQAAKL
790 800 810 820 830
YRELRANVVS NVRQQYQATG FLWEQYSDQD GRGMGCRPFQ GWTSLVLLIM AEEY