F4HTM3
PR
Gene name |
GCS1 (KNF, MUC, RSW, At1g67490, F12B7.4, T1F15.4) |
Protein name |
Mannosyl-oligosaccharide glucosidase GCS1 |
Names |
Alpha-glucosidase 1, Glucosidase 1, Protein KNOPF, Protein MUNCHKIN |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G67490 |
EC number |
3.2.1.106: Glycosidases, ie enzymes hydrolyzing O- and S-glycosyl compounds |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for F4HTM3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-F4HTM3-F1 | Predicted | AlphaFoldDB |
82 variants for F4HTM3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_1_25286553_C_T | 10 | R>H | No | 1000Genomes | |
| ENSVATH13759140 | 19 | S>Y | No | 1000Genomes | |
| tmp_1_25286517_G_A | 22 | S>F | No | 1000Genomes | |
| ENSVATH05092576 | 33 | R>P | No | 1000Genomes | |
| tmp_1_25286482_G_T | 34 | R>S | No | 1000Genomes | |
| ENSVATH05092575 | 44 | G>D | No | 1000Genomes | |
| ENSVATH01493878 | 63 | V>I | No | 1000Genomes | |
| ENSVATH13759139 | 67 | V>L | No | 1000Genomes | |
| ENSVATH14440398 | 75 | G>W | No | 1000Genomes | |
| tmp_1_25286323_T_G | 87 | I>L | No | 1000Genomes | |
| tmp_1_25286174_C_A | 107 | E>D | No | 1000Genomes | |
| ENSVATH01493875 | 119 | Y>N | No | 1000Genomes | |
| ENSVATH00129364 | 122 | V>F | No | 1000Genomes | |
| ENSVATH13759133 | 126 | T>I | No | 1000Genomes | |
| tmp_1_25285986_C_G | 143 | M>I | No | 1000Genomes | |
| ENSVATH14440373 | 177 | N>S | No | 1000Genomes | |
| ENSVATH05092571 | 189 | K>T | No | 1000Genomes | |
| ENSVATH01493873 | 197 | G>E | No | 1000Genomes | |
| tmp_1_25285816_G_A | 200 | A>V | No | 1000Genomes | |
| tmp_1_25285583_T_C | 230 | N>S | No | 1000Genomes | |
| ENSVATH13759127 | 239 | L>I | No | 1000Genomes | |
| tmp_1_25285542_T_C | 244 | S>G | No | 1000Genomes | |
| ENSVATH14440372 | 255 | V>I | No | 1000Genomes | |
| tmp_1_25285482_A_G | 264 | S>P | No | 1000Genomes | |
| ENSVATH01493871 | 302 | Q>K | No | 1000Genomes | |
| tmp_1_25284894_C_A | 333 | G>V | No | 1000Genomes | |
| ENSVATH00129361 | 336 | G>V | No | 1000Genomes | |
| ENSVATH14440370 | 338 | S>N | No | 1000Genomes | |
| tmp_1_25284853_T_A | 347 | S>C | No | 1000Genomes | |
| tmp_1_25284850_G_C | 348 | L>V | No | 1000Genomes | |
| ENSVATH05092551 | 349 | T>R | No | 1000Genomes | |
| ENSVATH01493865 | 373 | K>N | No | 1000Genomes | |
| tmp_1_25283984_T_C | 378 | H>R | No | 1000Genomes | |
| ENSVATH05092533 | 387 | R>K | No | 1000Genomes | |
| tmp_1_25283919_A_G | 400 | F>L | No | 1000Genomes | |
| ENSVATH05092522 | 459 | R>H | No | 1000Genomes | |
| ENSVATH13759110 | 459 | R>S | No | 1000Genomes | |
| tmp_1_25283398_A_G | 484 | L>S | No | 1000Genomes | |
| ENSVATH05092521 | 489 | L>W | No | 1000Genomes | |
| ENSVATH00129350 | 512 | V>A | No | 1000Genomes | |
| ENSVATH01493858 | 519 | A>T | No | 1000Genomes | |
| ENSVATH00129349 | 520 | I>V | No | 1000Genomes | |
| tmp_1_25282839_G_A | 528 | S>L | No | 1000Genomes | |
| ENSVATH00129348 | 529 | E>D | No | 1000Genomes | |
| tmp_1_25282786_C_A | 546 | A>S | No | 1000Genomes | |
| tmp_1_25282775_C_A | 549 | Q>H | No | 1000Genomes | |
| ENSVATH13759108 | 552 | N>S | No | 1000Genomes | |
| tmp_1_25282761_G_A | 554 | S>F | No | 1000Genomes | |
| ENSVATH05092497 | 574 | Q>R | No | 1000Genomes | |
| tmp_1_25282436_T_A | 579 | K>M | No | 1000Genomes | |
| ENSVATH00129339 | 609 | L>R | No | 1000Genomes | |
| ENSVATH05092488 | 631 | N>D | No | 1000Genomes | |
| tmp_1_25281885_A_C | 632 | Y>D | No | 1000Genomes | |
| ENSVATH00129338 | 636 | V>A | No | 1000Genomes | |
| ENSVATH13759080 | 651 | D>E | No | 1000Genomes | |
| ENSVATH05092486 | 654 | Y>H | No | 1000Genomes | |
| tmp_1_25281714_T_G | 654 | Y>S | No | 1000Genomes | |
| tmp_1_25281696_A_C | 660 | F>C | No | 1000Genomes | |
| ENSVATH01493846 | 664 | T>I | No | 1000Genomes | |
| tmp_1_25281542_T_C | 672 | K>E | No | 1000Genomes | |
| ENSVATH05092483 | 676 | Q>L | No | 1000Genomes | |
| ENSVATH13759077 | 679 | G>S | No | 1000Genomes | |
| ENSVATH05092482 | 680 | Q>K | No | 1000Genomes | |
| tmp_1_25281499_A_G | 686 | V>A | No | 1000Genomes | |
| ENSVATH05092480 | 690 | F>Y | No | 1000Genomes | |
| ENSVATH00129336 | 693 | P>S | No | 1000Genomes | |
| ENSVATH14440332 | 701 | L>F | No | 1000Genomes | |
| ENSVATH00129335 | 701 | L>V | No | 1000Genomes | |
| tmp_1_25281445_A_G | 704 | V>A | No | 1000Genomes | |
| ENSVATH05092479 | 712 | R>T | No | 1000Genomes | |
| ENSVATH05092470 | 725 | L>F | No | 1000Genomes | |
| ENSVATH01493843 | 726 | D>E | No | 1000Genomes | |
| ENSVATH13759076 | 726 | D>N | No | 1000Genomes | |
| ENSVATH01493842 | 727 | L>F | No | 1000Genomes | |
| ENSVATH14440331 | 729 | S>P | No | 1000Genomes | |
| ENSVATH13759075 | 734 | L>F | No | 1000Genomes | |
| ENSVATH05092463 | 779 | Y>H | No | 1000Genomes | |
| tmp_1_25280900_C_T | 789 | R>K | No | 1000Genomes | |
| tmp_1_25280877_T_C | 797 | T>A | No | 1000Genomes | |
| ENSVATH01493839 | 797 | T>R | No | 1000Genomes | |
| tmp_1_25280670_G_C | 841 | T>S | No | 1000Genomes | |
| ENSVATH13759071 | 851 | I>S | No | 1000Genomes |
No associated diseases with F4HTM3
Functions
| Description | ||
|---|---|---|
| EC Number | 3.2.1.106 | Glycosidases, ie enzymes hydrolyzing O- and S-glycosyl compounds |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| alpha-1,4-glucosidase activity | Catalysis of the hydrolysis of terminal, non-reducing alpha-(1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose. |
| Glc3Man9GlcNAc2 oligosaccharide glucosidase activity | Catalysis of the exohydrolysis of the non-reducing terminal glucose residue in the mannosyl-oligosaccharide Glc(3)Man(9)GlcNAc(2). |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| epidermal cell differentiation | The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis. |
| oligosaccharide metabolic process | The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. |
| protein N-linked glycosylation | A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan. |
| root epidermal cell differentiation | The process in which a relatively unspecialized cell in the root epidermis acquires the specialized features of a trichoblast or atrichoblast. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O88941 | Mogs | Mannosyl-oligosaccharide glucosidase | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTGASRRSAR | GRIKSSSLSP | GSDEGSAYPP | SIRRGKGKEL | VSIGAFKTNL | KILVGLIILG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IIVIYFVINR | LVRHGLLFDE | SQKPRVITPF | PAPKVMDLSM | FQGEHKESLY | WGTYRPHVYF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GVRARTPLSL | VAGLMWLGVK | DEMYVMRHFC | ENSDDLSTFG | WREHNGRDYG | RQELVENDMV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IETSFVKSKG | DGLGYGGDWA | VRIDVKNKGL | NDDVKRSAHL | FFYLADEGGN | VLNLGQDGLD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FQGSSLLVSG | SREDVGDWQI | HLKSQNQLET | HYSGFKTPHI | YNLSDLVQQN | LALQARKFGR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LQLSDTSEDS | SNIYIFQISG | RLPFTIDIPF | ISGIKGESSN | VEKRLTSLTG | LPLSDLLKKK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| HQEFDAKFNE | CFKLSEKHDS | ETLGVGRTAI | ANMLGGIGYF | YGQSKIYVPK | STQPGSRDNF |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LLYWPAELYT | AVPSRPFFPR | GFLWDEGFHQ | LLIWRWDIRI | TLDIVGHWLD | LLNIDGWIPR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| EQILGAEALS | KVPEEFVVQY | PSNGNPPTLF | LVIRDLIDAI | RMEKFVASEK | DEVLSFLERA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SVRLDAWFQW | FNTSQKGKEI | GSYFWHGRDN | TTTQELNPKT | LSSGLDDYPR | ASHPSEDERH |
| 610 | 620 | 630 | 640 | 650 | 660 |
| VDLRCWMYLA | ADCMHSITEL | LGKEDKLSKE | NYNSTVKLLS | NFNLLNQMHY | DSDYGAYFDF |
| 670 | 680 | 690 | 700 | 710 | 720 |
| GNHTEKVKLI | WKEVIQENGQ | LSRQLVRKTF | GKPKLKLVPH | LGYVSFFPFM | SRIIPPDSPI |
| 730 | 740 | 750 | 760 | 770 | 780 |
| LEKQLDLISN | RSILWSDYGL | VSLAKTSSMY | MKRNTEHDAP | YWRGPIWMNM | NYMILSSLYH |
| 790 | 800 | 810 | 820 | 830 | 840 |
| YSIVDGPYRE | KSKAIYTELR | SNLIRNVVRN | YYETGYIWEQ | YDQVKGTGKG | TRLFTGWSAL |
| 850 | |||||
| TLLIMSEDYP | IF |