O77784
Gene name |
IDH3B |
Protein name |
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial |
Names |
Isocitric dehydrogenase subunit beta, NAD(+)-isocitrate dehydrogenase subunit 1, IDH1, NAD(+)-specific ICDH subunit beta |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:613338 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O77784
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O77784-F1 | Predicted | AlphaFoldDB |
48 variants for O77784
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs456695637 | 2 | A>G | No | EVA | |
| rs441953434 | 3 | A>D | No | EVA | |
| rs441953434 | 3 | A>G | No | EVA | |
| rs472670602 | 4 | L>H | No | EVA | |
| rs472670602 | 4 | L>R | No | EVA | |
| rs441306202 | 5 | S>G | No | EVA | |
| rs478017101 | 5 | S>R | No | EVA | |
| rs457818452 | 5 | S>T | No | EVA | |
| rs443509909 | 6 | R>P | No | EVA | |
| rs480538861 | 7 | V>A | No | EVA | |
| rs463633567 | 7 | V>L | No | EVA | |
| rs448901484 | 11 | T>P | No | EVA | |
| rs459392727 | 12 | R>P | No | EVA | |
| rs457090661 | 20 | P>H | No | EVA | |
| rs457090661 | 20 | P>L | No | EVA | |
| rs473996895 | 21 | G>R | No | EVA | |
| rs459663662 | 22 | A>S | No | EVA | |
| rs438363104 | 30 | T>P | No | EVA | |
| rs458423162 | 32 | A>G | No | EVA | |
| rs444101232 | 33 | Q>H | No | EVA | |
| rs481683376 | 33 | Q>R | No | EVA | |
| rs460862177 | 42 | D>A | No | EVA | |
| rs481204784 | 46 | E>* | No | EVA | |
| rs480110606 | 105 | K>N | No | EVA | |
| rs475019243 | 128 | Y>S | No | EVA | |
| rs434023640 | 130 | M>L | No | EVA | |
| rs477779796 | 179 | A>T | No | EVA | |
| rs449732333 | 182 | V>A | No | EVA | |
| rs469871593 | 184 | E>D | No | EVA | |
| rs435312665 | 190 | T>A | No | EVA | |
| rs455000297 | 190 | T>N | No | EVA | |
| rs468801777 | 191 | R>* | No | EVA | |
| rs434247122 | 202 | F>Y | No | EVA | |
| rs471145912 | 213 | V>G | No | EVA | |
| rs456424912 | 216 | V>G | No | EVA | |
| rs476721209 | 217 | H>P | No | EVA | |
| rs461872866 | 219 | A>G | No | EVA | |
| rs472453948 | 220 | N>H | No | EVA | |
| rs441026430 | 220 | N>K | No | EVA | |
| rs476942617 | 303 | F>L | No | EVA | |
| rs470137153 | 312 | A>V | No | EVA | |
| rs452814460 | 362 | D>H | No | EVA | |
| rs476179282 | 363 | M>L | No | EVA | |
| rs444390866 | 364 | G>C | No | EVA | |
| rs461359452 | 371 | D>N | No | EVA | |
| rs481527532 | 379 | H>N | No | EVA | |
| rs440483516 | 381 | H>P | No | EVA | |
| rs460139674 | 382 | P>T | No | EVA |
No associated diseases with O77784
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| mitochondrial isocitrate dehydrogenase complex (NAD+) | Mitochondrial complex that possesses isocitrate dehydrogenase (NAD+) activity. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| magnesium ion binding | Binding to a magnesium (Mg) ion. |
| NAD binding | Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. |
| oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| isocitrate metabolic process | The chemical reactions and pathways involving isocitrate, the anion of isocitric acid, 1-hydroxy-1,2,3-propanetricarboxylic acid. Isocitrate is an important intermediate in the TCA cycle and the glycoxylate cycle. |
| tricarboxylic acid cycle | A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAALSRVRWL | TRALVAAPNP | GAWRSLCTST | VAQASSRTQG | EDVRVEGAFP | VTMLPGDGVG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PELMHAVKEV | FKAASVPVEF | QEHHLSEVQN | MASEEKLEQV | LSSMKENKVA | IIGKIHTPME |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YKGELASYDM | RLRRKLDLFA | NVVHVKSLPG | YKTRHNNLDL | VIIREQTEGE | YSSLEHESAR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GVIECLKIVT | RTKSQRIAKF | AFDYATKKGR | GKVTAVHKAN | IMKLGDGLFL | QCCEEVAELY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PKIKFEKMII | DNCCMQLVQN | PYQFDVLVMP | NLYGNIIDNL | AAGLVGGAGV | VPGESYSAEY |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AVFETGARHP | FAQAVGRNIA | NPTAMLLSAS | NMLRHLNLEH | HSNMIAEAVK | KVIKVGKVRT |
| 370 | 380 | ||||
| RDMGGYSTTT | DFIKSVIGHL | HPYGG |