O76373

PR
Gene name
ccpp-1
Protein name
Cytosolic carboxypeptidase 1
Names
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_F56H1.5
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

363-481 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O76373

Entry ID Method Resolution Chain Position Source
AF-O76373-F1 Predicted AlphaFoldDB

No variants for O76373

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O76373

No associated diseases with O76373

2 regional properties for O76373

Type Name Position InterPro Accession
domain Peptidase M14, carboxypeptidase A 731 - 1005 IPR000834
domain Cytosolic carboxypeptidase, N-terminal 589 - 691 IPR040626

Functions

Description
EC Number
Subcellular Localization
  • Perikaryon
  • Cell projection, cilium
  • Cell projection, dendrite
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cilium A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
dendrite A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
perikaryon The portion of the cell soma (neuronal cell body) that excludes the nucleus.

2 GO annotations of molecular function

Name Definition
metallocarboxypeptidase activity Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
zinc ion binding Binding to a zinc ion (Zn).

4 GO annotations of biological process

Name Definition
C-terminal protein deglutamylation The removal of a C-terminal, gene-encoded glutamate residue from a protein.
oviposition The deposition of eggs (either fertilized or not) upon a surface or into a medium such as water.
protein side chain deglutamylation The removal of a glutamate residue from the side chain of a protein. Glutamate side chains are added to glutamic acid residues within the primary protein sequence during polyglutamylation.
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9VY99 Nna1 Cytosolic carboxypeptidase Nna1 Drosophila melanogaster (Fruit fly) PR
10 20 30 40 50 60
MPSDSDDVAA VKQPWSQLIV DISNFLSEHP QSKTSQALLP SCNGVWSDEE KLELIEAFGH
70 80 90 100 110 120
KKQSHLTKSG VKAVLAAFEG DRTQPDVIFL CRLLHLIFSH FSSENDRKKE KYIVKCDVIA
130 140 150 160 170 180
TLTRITRKRI IMTLDVTDES SIDHNLDEVL WKLLHKIGLK DPRVSLKVRM GGLISPMCKL
190 200 210 220 230 240
FIQKDTLPEL FLPFFIKISR SPRNGQAIGR YEGFMTRLLV KIKALDASDQ TSQVLLLDKH
250 260 270 280 290 300
LQLLFFTMKN KRTRTQLLRE NICKYLLEVL RRHLASSSNS RPTRLLSSLF GTFDKSLSAA
310 320 330 340 350 360
HTEVVIGTIA ILRLLSNFKK ARDELKNLQV LDICSRELKE FWSDEWKTGP KSRIVDSLSA
370 380 390 400 410 420
LCLRCMSPLP YPLETRRFPI DFPLPTATPS TPGGHGRIRN SSSINISFDN GRSSDEDGMD
430 440 450 460 470 480
EEDEAFVRDD DDEGKDDRGS DDDDGKDDDE INGALPKTTR LNPQQLAKYA PFFVENEQGT
490 500 510 520 530 540
LQPTFSMIYQ TNQESWRSIC EKTRHVMPIH HHLPIEMFNT PTRIREKTAK TSNNMKKMII
550 560 570 580 590 600
EELDKPERSA TSNQVIYDLD TAAFDGLPSP ELPFVTGGGK LDTSKDLQFD SRFESGNLRM
610 620 630 640 650 660
VIQVAPTHYE LFLSPDVNQL RDHYQWFFFQ VSNMRKSVKY TFEIVNCLKS TSLYSQGMQP
670 680 690 700 710 720
VMYSMMESAN GWRRVGENVC YFRNLYINEN EEKKNVEEQK KKKYYYSIRF NVTFQNTGDI
730 740 750 760 770 780
CYIAYHYPYT YSFLNSSLSM LKKRKQENVY CREDVIGHSL AGNPIKMLTI TTPASAAEIA
790 800 810 820 830 840
AREVIVLSAR VHPGETNASW IMQGILENLL CRQSNEMYRL RESFIFKIVP MINPDGVTNG
850 860 870 880 890 900
SHRCSLAGID LNRMWDRPNE ALHPEVFATK AIIQYLCEVA NKKPFAYVDI HGHSKKWDYF
910 920 930 940 950 960
VYGNNASESW RADDVLDVGA AQLEEELHLA LPKALEATCP SRFNASECRF NITRAKESSA
970 980 990 1000 1010
RVNVWRQFGV STAYTLESTF CGFHKGQNSG YQINTSDLKE IGRDLLHSFL EMTKT