AiPD: Autoinhibited Protein Database

O75794

Gene name	CDC123 (C10orf7, D123)
Protein name	Cell division cycle protein 123 homolog
Names	Protein D123, HT-1080, PZ32
Species	Homo sapiens (Human)
KEGG Pathway	hsa:8872
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

23-104 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

23-104 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

3 structures for O75794

Entry ID	Method	Resolution	Chain	Position	Source
8PHD	X-ray	208 A	A/C	1-336	PDB
8PHV	X-ray	197 A	A/C	1-336	PDB
AF-O75794-F1	Predicted				AlphaFoldDB

238 variants for O75794

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA5409269 rs778175088	2	K>E		No	ClinGen ExAC gnomAD
CA5409271 rs764952080	5	H>QSLHWN*		No	ClinGen ExAC
CA376018988 rs1422079302	5	H>R		No	ClinGen gnomAD
CA202599367 rs780672584	6	V>L		No	ClinGen Ensembl
CA5409273 rs138564420	7	L>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5409274 rs138564420	7	L>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5409275 rs769978738	8	H>P		No	ClinGen ExAC TOPMed
rs1564430178 CA376019001	8	H>Y		No	ClinGen Ensembl
rs375416169 CA5409276	9	C>*		No	ClinGen ESP ExAC gnomAD
rs1219379123 CA376019012	9	C>S		No	ClinGen TOPMed
rs1374978565 CA376019016	10	Q>E		No	ClinGen gnomAD
rs1415346823 CA376019020	10	Q>R		No	ClinGen gnomAD
rs762685799 CA5409277	11	F>L		No	ClinGen ExAC gnomAD
CA5409278 rs768428123	12	S>F		No	ClinGen ExAC TOPMed gnomAD
CA202599483 rs768428123	12	S>Y		No	ClinGen ExAC TOPMed gnomAD
CA376019039 rs1232065787	13	A>V		No	ClinGen gnomAD
CA376019053 rs1277822590	15	Y>C		No	ClinGen gnomAD
rs1312610274 CA376019061	16	P>L		No	ClinGen gnomAD
rs1312610274 CA376019062	16	P>R		No	ClinGen gnomAD
CA376019087 rs767206968	20	G>D		No	ClinGen ExAC TOPMed gnomAD
rs767206968 CA5409283	20	G>V		No	ClinGen ExAC TOPMed gnomAD
rs1457112370 CA376019089	21	V>L		No	ClinGen TOPMed
rs1350484365 CA376019645	26	V>F		No	ClinGen gnomAD
CA376019651 rs1296267715	27	I>F		No	ClinGen gnomAD
rs760295026 CA5409309	28	L>P		No	ClinGen ExAC gnomAD
CA5409310 rs765850399	29	P>L		No	ClinGen ExAC gnomAD
CA376019674 rs1353855260	31	P>S		No	ClinGen gnomAD
rs1227314142 CA376019694	34	V>L		No	ClinGen gnomAD
rs1261613976 CA376019737	40	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA5409314 rs751899083	41	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1300721430 CA376019768	44	L>V		No	ClinGen TOPMed
rs1265710997 CA376019831	49	R>K		No	ClinGen gnomAD
rs762166828 CA5409336	50	D>V		No	ClinGen ExAC gnomAD
rs767809354 CA5409337	52	P>S		No	ClinGen ExAC gnomAD
CA376020975 rs767809354	52	P>T		No	ClinGen ExAC gnomAD
CA5409338 rs368224444	53	P>L		No	ClinGen ESP ExAC gnomAD
rs1234489864 CA376021037	55	H>R		No	ClinGen gnomAD
rs1341927716 CA376021097	58	P>R		No	ClinGen TOPMed gnomAD
CA5409340 rs766413197	58	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs754964626 CA376021107	59	D>G		No	ClinGen ExAC TOPMed gnomAD
rs754964626 CA5409342	59	D>V		No	ClinGen ExAC TOPMed gnomAD
rs753936146 CA5409341	59	D>Y		No	ClinGen ExAC TOPMed gnomAD
rs1376978351 CA376021122	60	S>G		No	ClinGen gnomAD
rs150662961 CA5409343	63	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA376021271 rs1196969500	67	I>T		No	ClinGen TOPMed gnomAD
rs1219597252 CA376021295	68	Q>H		No	ClinGen TOPMed
rs935509051 CA202618213	70	S>P		No	ClinGen gnomAD
CA376021358 rs1291175036	73	E>K		No	ClinGen TOPMed
rs1588671850 CA376021375	75	T>P		No	ClinGen Ensembl
rs1199476947 CA376021404	77	T>M		No	ClinGen TOPMed gnomAD
rs576857381 CA5409369	78	L>P		No	ClinGen ExAC gnomAD
rs758301266	79	T>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs138912400 CA5409370	79	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA202622901 rs149270225	80	A>V		No	ClinGen ESP
CA376022082 rs1564435594	82	E>A		No	ClinGen Ensembl
rs938691051 CA202622910	84	P>S		No	ClinGen TOPMed gnomAD
CA376022154 rs1286541186	87	A>T		No	ClinGen gnomAD
rs778633088 CA5409395	89	K>E		No	ClinGen ExAC gnomAD
CA376022207 rs1179793011	90	V>I		No	ClinGen gnomAD
rs747698461 CA5409396	91	Q>*		No	ClinGen ExAC gnomAD
rs559601502 CA5409397	91	Q>R		No	ClinGen 1000Genomes ExAC gnomAD
COSM1580671 CA5409398 rs192960310	92	E>D	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA5409399 rs376245493	95	N>S		No	ClinGen ExAC TOPMed gnomAD
CA5409400 rs376245493	95	N>T		No	ClinGen ExAC TOPMed gnomAD
rs774688918 CA5409404	98	G>E		No	ClinGen ExAC gnomAD
rs752899035 CA5409403 CA202622987	98	G>R		No	ClinGen ExAC TOPMed gnomAD
CA376022414 rs1185659696	100	S>N		No	ClinGen gnomAD
rs767388939 CA5409406	104	K>N		No	ClinGen ExAC
CA202623019 rs975189042	107	W>C		No	ClinGen TOPMed
rs1374741358 CA376022586	110	P>L		No	ClinGen gnomAD
rs766339097 CA5409409	110	P>S		No	ClinGen ExAC gnomAD
rs185376289 CA376022594	111	R>K		No	ClinGen 1000Genomes ExAC gnomAD
rs185376289 CA5409410	111	R>M		No	ClinGen 1000Genomes ExAC gnomAD
CA376023034 rs752168458	113	A>E		No	ClinGen ExAC TOPMed gnomAD
rs752168458 CA5409430	113	A>V		No	ClinGen ExAC TOPMed gnomAD
CA202624461 rs772896759	115	W>C		No	ClinGen Ensembl
rs777291390 CA5409433	117	A>E		No	ClinGen ExAC gnomAD
CA202624490 rs949778008	120	S>N		No	ClinGen TOPMed gnomAD
CA376023143 rs949778008	120	S>T		No	ClinGen TOPMed gnomAD
rs749636259 CA5409434	122	L>V		No	ClinGen ExAC gnomAD
CA5409435 rs756604050	126	T>S		No	ClinGen ExAC gnomAD
rs769023452 CA5409438	127	L>R		No	ClinGen ExAC gnomAD
rs1345968916 CA376023223	129	D>G		No	ClinGen gnomAD
CA5409440 rs748209580	129	D>N		No	ClinGen ExAC gnomAD
CA5409441 rs772124434	130	I>V		No	ClinGen ExAC gnomAD
CA5409443 rs760876745	135	K>R		No	ClinGen ExAC gnomAD
rs770782654 CA5409444	136	S>N		No	ClinGen ExAC gnomAD
CA376023280 rs1319396144	138	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs759324048 CA5409447	142	R>C		No	ClinGen ExAC TOPMed gnomAD
CA5409446 rs759324048	142	R>G		No	ClinGen ExAC TOPMed gnomAD
rs752610319 CA5409448 COSM1474404	142	R>H	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs762379641 CA5409449	143	D>A		No	ClinGen ExAC TOPMed gnomAD
CA376023335 rs1287908897	146	Q>*		No	ClinGen TOPMed
CA5409451 rs751322040	147	P>L		No	ClinGen ExAC gnomAD
rs753215008 CA5409477	148	F>C		No	ClinGen ExAC
CA5409478 rs754739630	148	F>L		No	ClinGen ExAC TOPMed gnomAD
CA376024348 rs1206125040	149	I>T		No	ClinGen gnomAD
rs1417388405 CA376024337	149	I>V		No	ClinGen TOPMed
rs866260755 CA202639458	150	H>D		No	ClinGen Ensembl
CA5409479 rs777882836	151	C>F		No	ClinGen ExAC gnomAD
CA5409480 rs747119577	152	T>I		No	ClinGen ExAC TOPMed gnomAD
CA376024407 rs1203259824	153	D>G		No	ClinGen gnomAD
CA376024439 rs1242731959	155	S>F		No	ClinGen Ensembl
CA376024443 rs1019484819	156	P>A		No	ClinGen TOPMed
rs1019484819 CA202639469	156	P>T		No	ClinGen TOPMed
CA376024481 rs1258633088	158	P>L		No	ClinGen gnomAD
CA202639473 rs143995799	158	P>T		No	ClinGen ESP
rs781402437 CA376024491	159	C>F		No	ClinGen ExAC TOPMed gnomAD
rs781402437 CA5409482	159	C>Y		No	ClinGen ExAC TOPMed gnomAD
rs374042519 CA5409483	160	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1176749719 CA376024499	160	I>V		No	ClinGen gnomAD
CA202639504 rs367583669	161	E>A		No	ClinGen ESP
CA5409485 rs76480057	163	E>D		No	ClinGen ExAC TOPMed gnomAD
CA202594094 rs201194027	165	V>A		No	ClinGen 1000Genomes
rs201946780 CA202594092	165	V>F		No	ClinGen 1000Genomes
CA202594097 rs887320669	167	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA202594102 rs750545764	167	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA376010251 rs1197526152	169	W>*		No	ClinGen gnomAD
rs779308094 CA202594114	170	C>R		No	ClinGen Ensembl
CA376010302 rs1490154536	172	L>F		No	ClinGen gnomAD
CA202594117 rs139964730	179	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA
CA376010442 rs1199885801	179	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA376010454 rs1416089174	180	C>Y		No	ClinGen TOPMed gnomAD
rs1192015835 CA376010483	182	V>F		No	ClinGen gnomAD
CA5409508 COSM324958 rs544543131	185	N>S	lung [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC gnomAD
CA5409509 rs771779565	187	L>V		No	ClinGen ExAC gnomAD
CA202594141 rs868562052	188	I>T		No	ClinGen TOPMed gnomAD
CA5409527 rs780329452	190	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1279078908 CA376011364	192	Q>E		No	ClinGen TOPMed
CA376011454 rs754878568	195	Y>D		No	ClinGen ExAC TOPMed gnomAD
CA5409529 rs754878568	195	Y>H		No	ClinGen ExAC TOPMed gnomAD
CA376011491 rs1564257408	196	T>R		No	ClinGen Ensembl
rs372144142 CA202595148	197	Q>H		No	ClinGen Ensembl
CA5409530 rs778848148	199	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs1310740426 CA376011697	204	K>*		No	ClinGen gnomAD
rs1382116509 CA376011791	208	E>Q		No	ClinGen gnomAD
rs199685440 CA5409531	209	I>M		No	ClinGen ExAC gnomAD
rs772028466 CA5409532	210	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs199948914 CA5409534	210	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs199948914 CA5409533	210	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA376011831 rs1279366353	211	R>K		No	ClinGen TOPMed gnomAD
CA376011839 rs1238105092	212	C>R		No	ClinGen gnomAD
CA5409536 rs113251077	213	I>L		No	ClinGen 1000Genomes ExAC gnomAD
CA376011868 rs1486652350	213	I>M		No	ClinGen gnomAD
rs113251077 CA5409535	213	I>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1198360091 CA376011875	214	Q>E		No	ClinGen TOPMed gnomAD
rs759181793 CA5409537	214	Q>R		No	ClinGen ExAC gnomAD
CA5409539 COSM683057 rs774676048	217	F>L	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA376011989 rs1477719781	218	K>R		No	ClinGen Ensembl
rs762115529 CA5409540	219	K>E		No	ClinGen ExAC gnomAD
CA202595169 rs781357891	219	K>R		No	ClinGen gnomAD
CA5409541 rs543330915	220	H>R		No	ClinGen 1000Genomes ExAC gnomAD
rs376983285 CA5409543	221	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA202595175 rs375231033	222	Q>R		No	ClinGen TOPMed gnomAD
TCGA novel	224	K>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1405499137 CA376012418	226	L>V		No	ClinGen gnomAD
rs766356092 CA5409544	229	D>N		No	ClinGen ExAC gnomAD
rs886378710 CA202595757	232	F>L		No	ClinGen TOPMed gnomAD
rs751551758 CA5409570	233	D>G		No	ClinGen ExAC gnomAD
rs1268557743 CA376013022	233	D>N		No	ClinGen TOPMed gnomAD
CA376013019 rs1268557743	233	D>Y		No	ClinGen TOPMed gnomAD
CA202595777 rs781059221	234	I>M		No	ClinGen ExAC TOPMed gnomAD
rs373454189 CA5409571	234	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs997489109 CA202595764	234	I>V		No	ClinGen TOPMed
rs745412087 CA5409573	236	R>G		No	ClinGen ExAC gnomAD
rs1171169100 CA376013074	236	R>I		No	ClinGen gnomAD
rs779695804 CA5409575	238	S>R		No	ClinGen ExAC gnomAD
TCGA novel	240	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs202198297 CA5409600	241	K>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1234640762 CA376014763	241	K>R		No	ClinGen TOPMed
CA376014781 rs778582325 CA5409601	242	V>L		No	ClinGen ExAC gnomAD
rs1460018394 CA376014889	246	D>E		No	ClinGen TOPMed gnomAD
rs1183010764 CA376014946	249	P>T		No	ClinGen gnomAD
rs1482986586 CA376015015	254	T>A		No	ClinGen TOPMed
rs1272970345 CA376015041	255	D>E		No	ClinGen TOPMed
CA5409604 rs781768756	258	L>P		No	ClinGen ExAC gnomAD
CA376015099 rs1406968068	260	T>S		No	ClinGen TOPMed gnomAD
rs1160806519 CA376015140	262	E>G		No	ClinGen gnomAD
CA376015171 rs1403332098	264	L>Q		No	ClinGen gnomAD
CA376015179 rs1451310147	265	I>L		No	ClinGen gnomAD
CA376015183 rs1336771797	265	I>M		No	ClinGen gnomAD
CA376015194 rs1450741266	267	E>G		No	ClinGen gnomAD
CA5409606 rs200396218	269	N>S		No	ClinGen 1000Genomes ExAC gnomAD
rs1350371114 CA376015217	270	L>*		No	ClinGen gnomAD
CA5409609 rs142243159	272	G>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA
CA5409608 rs533667025	272	G>S		No	ClinGen ExAC TOPMed gnomAD
CA376015239 rs1203116629	273	D>H		No	ClinGen TOPMed gnomAD
rs1203116629 CA376015238	273	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1203116629 CA376015241	273	D>Y		No	ClinGen TOPMed gnomAD
CA5409611 rs761608292	274	F>L		No	ClinGen ExAC gnomAD
rs1444118429 CA376015267	275	S>R		No	ClinGen TOPMed gnomAD
rs1232133309 CA376015305	277	V>A		No	ClinGen gnomAD
rs576722777 CA5409612	277	V>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
CA5409614 rs546090484	279	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs765923556 CA5409615	279	A>V		No	ClinGen ExAC
CA376015336 rs1175670475	280	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA5409635 rs201298802	284	S>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs764794619 CA5409637	285	P>L		No	ClinGen ExAC TOPMed gnomAD
rs913696153 CA202603252	285	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs752328200 CA5409638	288	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs542550865 CA5409639	288	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
rs763787783 CA5409640	289	C>W		No	ClinGen ExAC gnomAD
rs750845234 CA5409641	291	N>H		No	ClinGen ExAC gnomAD
COSM35500 rs538371163 CA5409643	293	E>K	central_nervous_system [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1043788425 CA202603293	295	T>A		No	ClinGen Ensembl
TCGA novel	298	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA376017289 rs1380687691	299	S>R		No	ClinGen gnomAD
TCGA novel	300	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	301	Y>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5409648 rs772305529	301	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA5409649 rs773387080	302	L>F		No	ClinGen ExAC gnomAD
CA376017327 rs1312858426	305	R>Q		No	ClinGen gnomAD
CA376017325 rs1230579204	305	R>W		No	ClinGen TOPMed gnomAD
rs545126704 CA376017357	307	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5409650 rs545126704	307	P>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1588687068 CA376017368	308	K>Q		No	ClinGen Ensembl
TCGA novel	312	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs770706077 COSM427154 CA5409651	314	S>F	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs937991849 CA202603332	315	T>A		No	ClinGen Ensembl
CA5409652 rs776493318	315	T>I		No	ClinGen ExAC TOPMed gnomAD
rs1181162781 CA376017576	316	G>V		No	ClinGen TOPMed gnomAD
CA376017588 rs1588687086	317	E>G		No	ClinGen Ensembl
CA5409654 rs564944253	319	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs775160022 CA5409655	320	H>N		No	ClinGen ExAC TOPMed gnomAD
rs775160022 CA376017650	320	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs1013800906 CA202603374	321	K>Q		No	ClinGen Ensembl
rs1389591197 CA376017703	323	I>T		No	ClinGen gnomAD
TCGA novel	324	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1381961575 CA376017740	325	F>L		No	ClinGen TOPMed gnomAD
rs1334704684 CA376017729	325	F>L		No	ClinGen gnomAD
rs1334704684 CA376017731	325	F>V		No	ClinGen gnomAD
rs1453264482 CA376017761	327	K>E		No	ClinGen gnomAD
rs1314684622 CA376017774	327	K>N		No	ClinGen gnomAD
rs766703762 CA5409678	331	N>K		No	ClinGen ExAC gnomAD
CA5409677 rs761496407	331	N>S		No	ClinGen ExAC gnomAD
CA5409680 rs759781696	336	D>N		No	ClinGen ExAC gnomAD
CA376018005 rs1197493446 CA376018006	337	D>R		No	ClinGen gnomAD
rs1428741429 CA376018012	337	D>W		No	ClinGen gnomAD

No associated diseases with O75794

8 regional properties for O75794

Type	Name	Position	InterPro Accession
repeat	WD40 repeat	11 - 49	IPR001680-1
repeat	WD40 repeat	73 - 113	IPR001680-2
repeat	WD40 repeat	156 - 195	IPR001680-3
repeat	WD40 repeat	206 - 246	IPR001680-4
repeat	WD40 repeat	265 - 303	IPR001680-5
repeat	WD40 repeat	466 - 506	IPR001680-6
conserved_site	Protein phosphatase 2A regulatory subunit PR55, conserved site	73 - 87	IPR018067-1
conserved_site	Protein phosphatase 2A regulatory subunit PR55, conserved site	165 - 179	IPR018067-2

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

1 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

6 GO annotations of biological process

Name	Definition
cell cycle	The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cell division	The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
eukaryotic translation initiation factor 2 complex assembly	The aggregation, arrangement and bonding together of a set of components to form an eukaryotic translation initiation factor 2 complex.
positive regulation of cell population proliferation	Any process that activates or increases the rate or extent of cell proliferation.
positive regulation of translational initiation	Any process that activates or increases the frequency, rate or extent of translational initiation.
regulation of cell cycle	Any process that modulates the rate or extent of progression through the cell cycle.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q05791	CDC123	Cell division cycle protein 123	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR

10	20	30	40	50	60
MKKEHVLHCQ	FSAWYPFFRG	VTIKSVILPL	PQNVKDYLLD	DGTLVVSGRD	DPPTHSQPDS
70	80	90	100	110	120
DDEAEEIQWS	DDENTATLTA	PEFPEFATKV	QEAINSLGGS	VFPKLNWSAP	RDAYWIAMNS
130	140	150	160	170	180
SLKCKTLSDI	FLLFKSSDFI	TRDFTQPFIH	CTDDSPDPCI	EYELVLRKWC	ELIPGAEFRC
190	200	210	220	230	240
FVKENKLIGI	SQRDYTQYYD	HISKQKEEIR	RCIQDFFKKH	IQYKFLDEDF	VFDIYRDSRG
250	260	270	280	290	300
KVWLIDFNPF	GEVTDSLLFT	WEELISENNL	NGDFSEVDAQ	EQDSPAFRCT	NSEVTVQPSP
310	320	330
YLSYRLPKDF	VDLSTGEDAH	KLIDFLKLKR	NQQEDD