O70480
Gene name |
Vamp4 |
Protein name |
Vesicle-associated membrane protein 4 |
Names |
VAMP-4 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:53330 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for O70480
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2NPS | X-ray | 250 A | A | 47-117 | PDB |
| AF-O70480-F1 | Predicted | AlphaFoldDB |
5 variants for O70480
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs222221228 | 33 | E>D | No | EVA | |
| rs3388511167 | 102 | S>F | No | EVA | |
| rs3390925449 | 119 | I>M | No | EVA | |
| rs3388508193 | 121 | A>D | No | EVA | |
| rs3388513021 | 130 | M>L | No | EVA |
No associated diseases with O70480
1 regional properties for O70480
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | v-SNARE, coiled-coil homology domain | 49 - 136 | IPR042855 |
Functions
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell surface | The external part of the cell wall and/or plasma membrane. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| integral component of presynaptic endosome membrane | The component of the presynaptic endosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| phagocytic vesicle | A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis. |
| SNARE complex | A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25. |
| synaptic vesicle | A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane. |
| trans-Golgi network | The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to interferon-gamma | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far. |
| Golgi ribbon formation | The formation of a continuous ribbon of interconnected Golgi stacks of flat cisternae. |
| Golgi to plasma membrane protein transport | The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane. |
| microtubule cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. |
| regulation of Golgi to plasma membrane protein transport | Any process that modulates the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane. |
| regulation of synaptic vesicle endocytosis | Any process that modulates the frequency, rate or extent of synaptic vesicle endocytosis. |
| SNARE complex assembly | The aggregation, arrangement and bonding together of a set of components to form a SNARE complex, a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. |
| synaptic vesicle to endosome fusion | Fusion of a synaptic vesicle with an endosome. |
| toxin transport | The directed movement of a toxin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
3 homologous proteins in AiPD
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPPKFKRHLN | DDDVTGSVKS | ERRNLLEDDS | DEEEDFFLRG | PSGPRFGPRN | DKIKHVQNQV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DEVIDVMQEN | ITKVIERGER | LDELQDKSES | LSDNATAFSN | RSKQLRRQMW | WRGCKIKAIM |
| 130 | 140 | ||||
| ALAAAILLLM | IIILIVVKFR | T |