O55201

PR
Gene name
Supt5h (Supt5)
Protein name
Transcription elongation factor SPT5
Names
DRB sensitivity-inducing factor large subunit, DSIF large subunit
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:20924
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-75 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O55201

Entry ID Method Resolution Chain Position Source
AF-O55201-F1 Predicted AlphaFoldDB

30 variants for O55201

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3397767350 11 E>* No EVA
rs3397767291 13 E>K No EVA
rs36326278 30 Q>R No EVA
rs3388890287 64 P>S No EVA
rs3388886332 67 K>T No EVA
rs3388893532 79 D>E No EVA
rs3388882574 154 G>E No EVA
rs3388895504 245 L>V No EVA
rs3388867433 287 D>N No EVA
rs3388867491 289 A>D No EVA
rs3388873854 379 V>M No EVA
rs3388886375 380 I>N No EVA
rs3388884029 393 K>N No EVA
rs3388896390 570 H>D No EVA
rs3388895497 577 K>M No EVA
rs3388884014 584 A>T No EVA
rs3388888989 610 G>D No EVA
rs3397702806 678 Q>E No EVA
rs3396928627 679 H>D No EVA
rs3388889003 731 H>Q No EVA
rs3388891555 767 S>T No EVA
rs3388894079 777 R>Q No EVA
rs3388891501 803 H>Q No EVA
rs3388888984 810 A>D No EVA
rs3388889076 822 T>A No EVA
rs3388882597 948 T>I No EVA
rs3397692537 992 V>L No EVA
rs3397694482 993 G>R No EVA
rs3388882587 1021 S>G No EVA
rs3388852670 1045 A>T No EVA

No associated diseases with O55201

17 regional properties for O55201

Type Name Position InterPro Accession
domain NGN domain 176 - 262 IPR005100
domain KOW 270 - 297 IPR005824-1
domain KOW 417 - 444 IPR005824-2
domain KOW 469 - 499 IPR005824-3
domain KOW 591 - 618 IPR005824-4
domain KOW 697 - 724 IPR005824-5
domain KOW 1028 - 1055 IPR005824-6
domain NusG-like, N-terminal 174 - 265 IPR006645
domain Spt5 transcription elongation factor, N-terminal 73 - 170 IPR022581
domain Spt5 C-terminal domain 766 - 902 IPR024945
domain NGN domain, eukaryotic 176 - 263 IPR039385
domain Spt5, KOW domain repeat 1 274 - 311 IPR041973
domain Spt5, KOW domain repeat 2 418 - 468 IPR041975
domain Spt5, KOW domain repeat 3 469 - 519 IPR041976
domain Spt5, KOW domain repeat 4 595 - 637 IPR041977
domain Spt5, KOW domain repeat 5 696 - 745 IPR041978
domain Spt5, KOW domain repeat 6 1022 - 1079 IPR041980

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
DSIF complex A heterodimeric protein complex formed of Spt4 and Spt5 proteins which is expressed in eukaryotes from yeast to man. DSIF is an inhibitory elongation factor that promotes RNA polymerase II transcriptional pausing, but can also stimulate transcriptional elongation under certain conditions, and may play a role in RNA processing via its physical association with mRNA capping enzymes.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
chromatin binding Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
enzyme binding Binding to an enzyme, a protein with catalytic activity.
mRNA binding Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
protein heterodimerization activity Binding to a nonidentical protein to form a heterodimer.

8 GO annotations of biological process

Name Definition
negative regulation of DNA-templated transcription, elongation Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase.
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
positive regulation of DNA-templated transcription, elongation Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase.
positive regulation of macroautophagy Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of DNA-templated transcription Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
transcription elongation by RNA polymerase II promoter The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9V460 Spt5 Transcription elongation factor SPT5 Drosophila melanogaster (Fruit fly) PR
O00267 SUPT5H Transcription elongation factor SPT5 Homo sapiens (Human) PR
Q9STN3 At4g08350 Putative transcription elongation factor SPT5 homolog 1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MSDSEDSNFS EEEDSERSSE AEEAEVEEDQ RSAAGSEKEE EPEEEEEEEE EYDEEEEEED
70 80 90 100 110 120
DDRPPKKPRH GGFILDEADV DDEYEDEDQW EDGAEDILEK EEIEASNIDN VVLDEDRSGA
130 140 150 160 170 180
RRLQNLWRDQ REEELGEYYM KKYAKSSVGE TVYGGSDELS DDITQQQLLP GVKDPNLWTV
190 200 210 220 230 240
KCKIGEERAT AISLMRKFIA YQFTDTPLQI KSVVAPEHVK GYIYVEAYKQ THVKQAIEGV
250 260 270 280 290 300
GNLRLGYWNQ QMVPIKEMTD VLKVVKEVAN LKPKSWVRLK RGIYKDDIAQ VDYVEPSQNT
310 320 330 340 350 360
ISLKMIPRID YDRIKARMSL KDWFAKRKKF KRPPQRLFDA EKIRSLGGDV ASDGDFLIFE
370 380 390 400 410 420
GNRYSRKGFL FKSFAMSAVI TEGVKPTLSE LEKFEDQPEG IDLEVVTEST GKEREHNFQP
430 440 450 460 470 480
GDNVEVCEGE LINLQGKVLS VDGNKITIMP KHEDLKDMLE FPAQELRKYF KMGDHVKVIA
490 500 510 520 530 540
GRFEGDTGLI VRVEENFVIL FSDLTMHELK VLPRDLQLCS ETASGVDVGG QHEWGELVQL
550 560 570 580 590 600
DPRTVGVIVR LERETFQVLN MHGKVVTVRH QAVTQKKDNR FAVALDSDQN NIHVKDIVKV
610 620 630 640 650 660
IDGPHSGREG EIRHLYRSFA FLHCKKLVEN GGMFVCKARH LVLAGGSKPR DVTNLTVGGF
670 680 690 700 710 720
TPMSPRISSP MHPSAEGQHG GFGSPGGMSR GRGRRDNELI GQTVRISQGP YKGYIGVVKD
730 740 750 760 770 780
ATESTARVEL HSTCQTISVD RQRLTTVDSQ RPGGMTSTYG RTPMYGSQTP MYGSGSRTPM
790 800 810 820 830 840
YGSQTPLQDG SRTPHYGSQT PLHDGSRTPA QSGAWDPNNP NTPSRAEEEY EYAFDDEPTP
850 860 870 880 890 900
SPQAYGGTPN PQTPGYPDPS SPQVNPQYNP QTPGTPAMYN TDQFSPYAAP SPQGSYQPSP
910 920 930 940 950 960
SPQSYHQVAP SPAGYQNTHS PASYHPTPSP MAYQASPSPS PVGYSPMTPG APSPGGYNPH
970 980 990 1000 1010 1020
TPGSGIEQNS SDWVTTDIQV KVRDTYLDTQ IVGQTGVIRS VTGGMCSVYL KDSEKVVSIS
1030 1040 1050 1060 1070 1080
SEHLEPITPT KNNKVKVILG EDREATGVLL SIDGEDGIIR MDLEDQQIKI LNLRFLGKLL
EA