O54941
PR
Gene name |
Smarce1 (Baf57) |
Protein name |
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 |
Names |
BRG1-associated factor 57, BAF57 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:57376 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O54941
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O54941-F1 | Predicted | AlphaFoldDB |
19 variants for O54941
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389193445 | 70 | L>M | No | EVA | |
| rs3389200067 | 95 | E>K | No | EVA | |
| rs3389214953 | 145 | A>V | No | EVA | |
| rs3389199130 | 161 | Q>H | No | EVA | |
| rs3389210418 | 169 | P>S | No | EVA | |
| rs3389193517 | 197 | Q>H | No | EVA | |
| rs3389214870 | 201 | R>S | No | EVA | |
| rs3389210494 | 221 | T>I | No | EVA | |
| rs3389169518 | 236 | V>G | No | EVA | |
| rs27071711 | 314 | S>T | No | EVA | |
| rs3389174957 | 353 | S>R | No | EVA | |
| rs3389136486 | 368 | E>V | No | EVA | |
| rs3389204125 | 372 | E>D | No | EVA | |
| rs3389136452 | 375 | D>E | No | EVA | |
| rs3389214911 | 377 | M>V | No | EVA | |
| rs3389200060 | 379 | V>L | No | EVA | |
| rs3389214922 | 380 | E>V | No | EVA | |
| rs3389209020 | 393 | S>R | No | EVA | |
| rs3402689679 | 409 | K>E | No | EVA |
No associated diseases with O54941
5 regional properties for O54941
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Thiamine pyrophosphate enzyme, TPP-binding | 405 - 515 | IPR011766 |
| domain | Thiamine pyrophosphate enzyme, central domain | 204 - 334 | IPR012000 |
| domain | Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain | 7 - 175 | IPR012001 |
| domain | Pyruvate decarboxylase/indolepyruvate decarboxylase-like, pyrimidine-binding domain | 9 - 172 | IPR047213 |
| domain | Pyruvate decarboxylase/indolepyruvate decarboxylase-like, PP-binding domain | 370 - 559 | IPR047214 |
11 GO annotations of cellular component
| Name | Definition |
|---|---|
| bBAF complex | A brain-specific SWI/SNF-type complex that contains eight or nine proteins, including both conserved (core) and nonconserved components; contains the ATPase product of either the SMARCA4/BAF190A/BRG1 gene, the mammalian ortholog of the yeast SNF2 gene, or the SMARCA2/BAF190B/BRM gene, the mammalian ortholog of the Drosophila brm (brahma) gene, or an ortholog of either of these genes. Compared to the neuron-specific nBAF complex (GO:0071565) it does not contain DPF1, DPF3 or SMARCC1 or their orthologs. May contain PB1/BAF180. |
| brahma complex | A SWI/SNF-type complex that contains 8 to 14 proteins, including both conserved (core) and nonconserved components; contains the ATPase product of the Drosophila brm (brahma) or mammalian SMARCA2/BAF190B/BRM gene, or an ortholog thereof. |
| chromatin | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. |
| kinetochore | A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules. |
| nBAF complex | A SWI/SNF-type complex that is found in post-mitotic neurons, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B genes. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. |
| npBAF complex | A SWI/SNF-type complex that is found in neural stem or progenitor cells, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A genes. The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. |
| nuclear matrix | The dense fibrillar network lying on the inner side of the nuclear membrane. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| RSC-type complex | A SWI/SNF-type complex that contains a bromodomain containing-protein, such as yeast Rsc1 or Rsc4 or mammalian PB1/BAF180. The RSC complex is generally recruited to RNA polymerase III promoters and is specifically recruited to RNA polymerase II promoters by transcriptional activators and repressors; it is also involved in non-homologous end joining. |
| SWI/SNF complex | A SWI/SNF-type complex that contains 8 to 14 proteins, including both conserved (core) and nonconserved components; contains the ATPase product of the yeast SNF2 or mammalian SMARCA4/BAF190A/BRG1 gene, or an ortholog thereof. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| N-acetyltransferase activity | Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. |
| nuclear receptor binding | Binding to a nuclear receptor protein. Nuclear receptor proteins are DNA-binding transcription factors which are regulated by binding to a ligand. |
| protein N-terminus binding | Binding to a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
14 GO annotations of biological process
| Name | Definition |
|---|---|
| chromatin remodeling | A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication. |
| negative regulation of DNA-templated transcription | Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. |
| neurogenesis | Generation of cells within the nervous system. |
| nucleosome disassembly | The controlled breakdown of nucleosomes, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. |
| positive regulation of cell differentiation | Any process that activates or increases the frequency, rate or extent of cell differentiation. |
| positive regulation of double-strand break repair | Any process that activates or increases the frequency, rate or extent of double-strand break repair. |
| positive regulation of myoblast differentiation | Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. |
| positive regulation of stem cell population maintenance | Any process that activates or increases the frequency, rate or extent of stem cell population maintenance. |
| positive regulation of T cell differentiation | Any process that activates or increases the frequency, rate or extent of T cell differentiation. |
| regulation of G0 to G1 transition | A cell cycle process that modulates the rate or extent of the transition from the G0 quiescent state to the G1 phase. |
| regulation of G1/S transition of mitotic cell cycle | Any signalling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle. |
| regulation of mitotic metaphase/anaphase transition | Any process that modulates the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin. |
| regulation of nucleotide-excision repair | Any process that modulates the frequency, rate or extent of nucleotide-excision repair. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
2 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q969G3 | SMARCE1 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 | Homo sapiens (Human) | PR |
| Q56A18 | Smarce1 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSKRPSYAPP | PTPAPATQMP | STPGFVGYNP | YSHLAYNNYR | LGGNPGTNSR | VTASSGITIP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KPPKPPDKPL | MPYMRYSRKV | WDQVKASNPD | LKLWEIGKII | GGMWRDLTDE | EKQEYLNEYE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AEKIEYNESM | KAYHNSPAYL | AYINAKSRAE | AALEEESRQR | QSRMEKGEPY | MSIQPAEDPD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DYDDGFSMKH | TATARFQRNH | RLISEILSES | VVPDVRSVVT | TARMQVLKRQ | VQSLMVHQRK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LEAELLQIEE | RHQEKKRKFL | ESTDSFNNEL | KRLCGLKVEV | DMEKIAAEIA | QAEEQARKRQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EEREKEAAEQ | AERSQSSMAP | EEEQVANKAE | EKKDEESIPM | ETEETHLEDT | AESQQNGEEG |
| 370 | 380 | 390 | 400 | 410 | |
| TSTPEDKESG | QEGVDSMEVE | GTSDSNTGSE | SNSATVEEPP | TDPVPEDEKK | E |