O42281

PR
Gene name
PRPH2 (RDS)
Protein name
Peripherin-2
Names
CRDS1, Photoreceptor outer segment membrane glycoprotein 1, Retinal degeneration slow protein
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:395899
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

20-90 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O42281

Entry ID Method Resolution Chain Position Source
AF-O42281-F1 Predicted AlphaFoldDB

12 variants for O42281

Variant ID(s) Position Change Description Diseaes Association Provenance
rs739535922 115 V>F No Ensembl
rs738858531 140 F>V No Ensembl
rs731359369 175 F>V No Ensembl
rs735563468 204 Y>D No Ensembl
rs740219748 218 S>P No Ensembl
rs738156855 227 V>A No Ensembl
rs736145228 229 N>H No Ensembl
rs1060365579 236 Y>C No Ensembl
rs738796775 252 E>G No Ensembl
rs313656855 294 A>T No Ensembl
rs315419117 306 W>G No Ensembl
rs314896697 336 A>G No Ensembl

No associated diseases with O42281

2 regional properties for O42281

Type Name Position InterPro Accession
conserved_site Peripherin/rom-1, conserved site 207 - 222 IPR018498
domain Peripherin, extracellular domain 120 - 262 IPR042026

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
photoreceptor outer segment The outer segment of a vertebrate photoreceptor that contains a stack of membrane discs embedded with photoreceptor proteins.

1 GO annotations of molecular function

Name Definition
protein homodimerization activity Binding to an identical protein to form a homodimer.

6 GO annotations of biological process

Name Definition
cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
detection of light stimulus involved in visual perception The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal.
photoreceptor cell outer segment organization A process that is carried out at the cellular level and results in the assembly, arrangement of constituent parts, or disassembly of the outer segment of a photoreceptor cell, a sensory cell that reacts to the presence of light. The outer segment of the photoreceptor cell contains the light-absorbing materials.
protein heterooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
retina development in camera-type eye The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
F7BWT7 Tspan15 Tetraspanin-15 Mus musculus (Mouse) PR
10 20 30 40 50 60
MALLKVKFNQ KKRVKLAQGL WLMNWFSVFA GIIVFSMGLF LKIELRKRSE VMDNSESHFV
70 80 90 100 110 120
PNSLILMGIL SCAFNGFAGK ICYDSLDPAK FAKWKPLLKP YLALCFFFNI LLFFVALICF
130 140 150 160 170 180
LMRGSLESTL AQGLKNSMKF YRDTDTPGRC FMKKTIDMLQ IEFKCCGNNG FKDWFEIQWI
190 200 210 220 230 240
SNRYLDFSSK EVKDRIKSNV DGRYLVDGVP FSCCNPSSPR PCIQYQVTNN SAHYSYDYQT
250 260 270 280 290 300
EELNLWGRGC REALLHYYSS MMSSMGAVVL LVWLFEMSVM VGLRLLHTSL ESIANPEDPE
310 320 330 340 350
CESEGWILEN SLKDTLKSAL ESLKKIGKFN QVEAGAEGAE GEEAGKTPAI TTVS