AiPD: Autoinhibited Protein Database

Gene name	Timm44 (Mimt44, Tim44)
Protein name	Mitochondrial import inner membrane translocase subunit TIM44
Names
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:21856
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

9-251 (Predicted disordered autoinhibitory region) PR

9-251 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-O35857-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388969599	2	A>E	No	EVA
rs3388969609	7	R>Q	No	EVA
rs3388961032	53	S>C	No	EVA
rs47638918	106	S>T	No	EVA
rs3388949834	132	S>N	No	EVA
rs3388969385	136	V>I	No	EVA
rs3388946310	191	D>E	No	EVA
rs3388966908	193	S>I	No	EVA
rs3388969093	209	K>N	No	EVA
rs3388972767	249	K>N	No	EVA
rs3388956228	253	V>I	No	EVA
rs3388969626	258	F>Y	No	EVA
rs3388922042	264	K>R	No	EVA
rs3388972816	279	L>*	No	EVA
rs3388972778	290	L>P	No	EVA
rs3388969412	293	K>Q	No	EVA
rs3388949802	301	T>M	No	EVA
rs3388922037	314	H>Y	No	EVA
rs236885052	316	L>I	No	EVA
rs3388922015	398	V>M	No	EVA
rs3412914705	428	D>Y	No	EVA

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for O35857

		Description
EC Number
Subcellular Localization	Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
fibrillar center	A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures.
mitochondrial inner membrane	The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial matrix	The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
chaperone binding	Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport.
enzyme binding	Binding to an enzyme, a protein with catalytic activity.

Name	Definition
intracellular protein transport	The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
protein import into mitochondrial matrix	The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
O35094	Timm44	Mitochondrial import inner membrane translocase subunit TIM44	Rattus norvegicus (Rat)	PR