O35094

PR
Gene name
Timm44 (Mimt44, Tim44)
Protein name
Mitochondrial import inner membrane translocase subunit TIM44
Names
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:29635
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

10-95 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O35094

Entry ID Method Resolution Chain Position Source
AF-O35094-F1 Predicted AlphaFoldDB

No variants for O35094

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O35094

No associated diseases with O35094

1 regional properties for O35094

Type Name Position InterPro Accession
domain Tim44-like domain 297 - 446 IPR007379

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side
  • Mitochondrion matrix
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
chaperone binding Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport.

4 GO annotations of biological process

Name Definition
cardiac muscle cell differentiation The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction.
intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
protein import into mitochondrial matrix The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together.
response to 3,3',5-triiodo-L-thyronine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 3,3',5-triiodo-L-thyronine stimulus.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O35857 Timm44 Mitochondrial import inner membrane translocase subunit TIM44 Mus musculus (Mouse) PR
10 20 30 40 50 60
MAAAALRGGW CRCPRRCLGS GIQFLSSHNL PRGGSSYQIS RPGGELTLTK SYSSGSRKGF
70 80 90 100 110 120
LSGLLDNIKQ ELAQNKEMKE SIKKFRDEAK KLEESDALQE ARRKYKTIES ETVRTSEAIK
130 140 150 160 170 180
KKLGELTGTV KESLDEVSKS DLGRKIKEGV EEAARTAKQS AESVSKGGEK LGKTAAFKAI
190 200 210 220 230 240
SQGVESVKKE IDESVLGHTG TYRRPERLRK RTEFAGAKFK ESKVFEANEE ALGVVLHKDS
250 260 270 280 290 300
KWYQQWKDFK DNNVVFNRFF EMKMKYDESD NVLIRASRAL TDKVTDLLGG LFSKTEMSEV
310 320 330 340 350 360
LTEILRVDPT FDKDRFLHQC ETDIIPNILE AMISGELDIL KDWCYEATYN QLAHSIQQAK
370 380 390 400 410 420
ALGLQFHSRI LDISNVDLAM GKMMEQGPVL IVTFQAQLVM VIKNPKGEVF DGDPDKVLRM
430 440 450
LYVWALCRDQ EELNPYAAWR LLDISASSTE QIL