Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for O35386

Entry ID Method Resolution Chain Position Source
AF-O35386-F1 Predicted AlphaFoldDB

15 variants for O35386

Variant ID(s) Position Change Description Diseaes Association Provenance
rs27063458 2 N>K No EVA
rs3388521942 23 P>S No EVA
rs251281257 27 A>S No EVA
rs3388523889 46 Y>F No EVA
rs3388527323 68 V>D No EVA
rs3391225828 92 E>V No EVA
rs3388528368 93 V>L No EVA
rs3413151097 115 D>E No EVA
rs3388529230 137 P>L No EVA
rs3411548084 189 I>F No EVA
rs3388523766 216 T>I No EVA
rs3388530495 217 L>M No EVA
rs3388521923 218 K>M No EVA
rs3388530517 243 S>I No EVA
rs3411652419 243 S>R No EVA

1 associated diseases with O35386

Without disease ID

No regional properties for O35386

Type Name Position InterPro Accession
No domain, repeats, and functional sites for O35386

Functions

Description
EC Number 1.14.11.18 With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
Subcellular Localization
  • Peroxisome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
9+0 non-motile cilium A non-motile cilium where the axoneme has a ring of nine outer microtubule doublets but no central microtubules (and is therefore called a 9+0 axoneme).
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
peroxisomal matrix The volume contained within the membranes of a peroxisome; in many cells the matrix contains a crystalloid core largely composed of urate oxidase.
peroxisome A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.

5 GO annotations of molecular function

Name Definition
carboxylic acid binding Binding to a carboxylic acid, an organic acid containing one or more carboxyl (COOH) groups or anions (COO-).
catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
ferrous iron binding Binding to a ferrous iron ion, Fe(II).
L-ascorbic acid binding Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species.
phytanoyl-CoA dioxygenase activity Catalysis of the reaction: 2-oxoglutarate + O(2) + phytanoyl-CoA = 2-hydroxyphytanoyl-CoA + CO(2) + succinate.

5 GO annotations of biological process

Name Definition
2-oxobutyrate catabolic process The chemical reactions and pathways resulting in the breakdown of 2-oxobutyrate, the anion of the organic acid 2-oxobutyric acid, which contains a ketone group on carbon 2.
2-oxoglutarate metabolic process The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism.
fatty acid alpha-oxidation A metabolic pathway by which 3-methyl branched fatty acids are degraded. These compounds are not degraded by the normal peroxisomal beta-oxidation pathway, because the 3-methyl blocks the dehydrogenation of the hydroxyl group by hydroxyacyl-CoA dehydrogenase. The 3-methyl branched fatty acid is converted in several steps to pristenic acid, which can then feed into the beta-oxidative pathway.
isoprenoid metabolic process The chemical reactions and pathways involving isoprenoid compounds, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.
methyl-branched fatty acid metabolic process The chemical reactions and pathways involving methyl-branched fatty acids, aliphatic monocarboxylic acids with methyl branches on the main chain.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O18778 PHYH Phytanoyl-CoA dioxygenase, peroxisomal Bos taurus (Bovine) PR
O14832 PHYH Phytanoyl-CoA dioxygenase, peroxisomal Homo sapiens (Human) PR
10 20 30 40 50 60
MNLTRAGARL QVLLGHLGRP SAPTIVAQPV SGLASPASFQ PEQFQYTLDN NVLTLEQRKF
70 80 90 100 110 120
YEENGFLVIK NLVSDDDIQR FRAEFERICR EEVKPPGIVI MRDVALAKQD YMPSDRMVSK
130 140 150 160 170 180
IQDFQEDEEL FRYCLLPEIL KYVECFTGPN IMALHGMLIN KPPDVGKKTS RHPLHQDLHY
190 200 210 220 230 240
FPFRPSNLIV CAWTAMEHID RNNGCLVVLP GTHKGTLKPH DYPKWEGGVN KMYHGIQDYD
250 260 270 280 290 300
PNSPRVHLVM EKGDTVFFHP LLIHGSGRNK TQGFRKAISC HFGSSDCQCI DVSGTSQENI
310 320 330
AREVVEMAEK KYGFQGVMDF KDTWIFRSRL VKGERINI