O18778
Gene name |
PHYH (LN1, PAHX) |
Protein name |
Phytanoyl-CoA dioxygenase, peroxisomal |
Names |
Phytanic acid oxidase, Phytanoyl-CoA alpha-hydroxylase, PhyH |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:281400 |
EC number |
1.14.11.18: With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O18778
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O18778-F1 | Predicted | AlphaFoldDB |
31 variants for O18778
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs473062411 | 3 | R>Q | No | EVA | |
| rs452814087 | 12 | V>F | No | EVA | |
| rs433087965 | 16 | H>R | No | EVA | |
| rs522353154 | 21 | S>L | No | EVA | |
| rs450603459 | 24 | T>I | No | EVA | |
| rs209515573 | 27 | A>S | No | EVA | |
| rs133068456 | 38 | S>T | No | EVA | |
| rs718030422 | 40 | H>Y | No | EVA | |
| rs724106506 | 80 | R>C | No | EVA | |
| rs133576003 | 86 | E>Q | No | EVA | |
| rs447863577 | 93 | V>L | No | EVA | |
| rs447863577 | 93 | V>M | No | EVA | |
| rs136371133 | 99 | S>L | No | EVA | |
| rs134434589 | 107 | T>A | No | EVA | |
| rs452959878 | 108 | K>E | No | EVA | |
| rs721743482 | 147 | T>N | No | EVA | |
| rs1117037286 | 150 | N>S | No | EVA | |
| rs110811906 | 154 | M>I | No | EVA | |
| rs209453111 | 165 | S>F | No | EVA | |
| rs42312254 | 188 | S>N | No | EVA | |
| rs382982209 | 201 | R>Q | No | EVA | |
| rs133799397 | 218 | Q>K | No | EVA | |
| rs132658757 | 235 | G>R | No | EVA | |
| rs434235338 | 268 | R>Q | No | EVA | |
| rs438210098 | 318 | T>A | No | EVA | |
| rs481652354 | 321 | D>V | No | EVA | |
| rs461526714 | 322 | V>F | No | EVA | |
| rs448102977 | 322 | V>G | No | EVA | |
| rs459185914 | 324 | T>S | No | EVA | |
| rs439158291 | 326 | R>L | No | EVA | |
| rs463601925 | 331 | K>N | No | EVA |
No associated diseases with O18778
No regional properties for O18778
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for O18778 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 1.14.11.18 | With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| peroxisome | A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| L-ascorbic acid binding | Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species. |
| metal ion binding | Binding to a metal ion. |
| phytanoyl-CoA dioxygenase activity | Catalysis of the reaction: 2-oxoglutarate + O(2) + phytanoyl-CoA = 2-hydroxyphytanoyl-CoA + CO(2) + succinate. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| fatty acid alpha-oxidation | A metabolic pathway by which 3-methyl branched fatty acids are degraded. These compounds are not degraded by the normal peroxisomal beta-oxidation pathway, because the 3-methyl blocks the dehydrogenation of the hydroxyl group by hydroxyacyl-CoA dehydrogenase. The 3-methyl branched fatty acid is converted in several steps to pristenic acid, which can then feed into the beta-oxidative pathway. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDRNRASARL | TVLLRHLGCR | SAGTIIAHHT | SGVGSLASFH | PQQFQYTREN | NVLSLEQRKF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YEENGFLVIK | NLVSDADIQR | FRNEFERICR | KEVKPLGLSV | MRDVTITKSE | YVPSEKVVSK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VQDFQEDEEL | FRYCTLPEIL | KYVECFTGPN | IMAMHTMLIN | KPPDSGKKTS | RHPLHQDLHY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FPFRPSNSIV | CAWTAMEHID | RNNGCLVVLP | GTHKGPLQPH | DYPQWEGGVN | IMFHGIQDYD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KNNARVHLVM | EKGDTVFFHP | LLIHGSGRNK | SQGFRKAISC | HFADANCHYI | DVEGTSQENI |
| 310 | 320 | 330 | |||
| EKEVVDIVRK | KYGFKDVTLK | DVWTFRGRVV | KGERINL |