O23404

PR
Gene name
PPDK (At4g15530, dl3805c, FCAALL.325)
Protein name
Pyruvate, phosphate dikinase 1, chloroplastic
Names
Pyruvate, orthophosphate dikinase 1
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT4G15530
EC number
2.7.9.1: Phosphotransferases with paired acceptors
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

3-118 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O23404

Entry ID Method Resolution Chain Position Source
AF-O23404-F1 Predicted AlphaFoldDB

65 variants for O23404

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH11796637 5 R>T No 1000Genomes
tmp_4_8870699_G_A 17 P>L No 1000Genomes
ENSVATH14206084 24 G>R No 1000Genomes
tmp_4_8870676_C_T 25 V>M No 1000Genomes
tmp_4_8870672_A_T 26 F>Y No 1000Genomes
ENSVATH06678137 41 N>H No 1000Genomes
ENSVATH06678137 41 N>Y No 1000Genomes
tmp_4_8870625_G_A 42 R>W No 1000Genomes
ENSVATH11796636 43 L>V No 1000Genomes
tmp_4_8870604_G_C 49 R>G No 1000Genomes
ENSVATH02844280 51 P>L No 1000Genomes
ENSVATH14206083 53 T>S No 1000Genomes
tmp_4_8870588_C_T 54 G>D No 1000Genomes
ENSVATH06678136 54 G>R No 1000Genomes
tmp_4_8870576_C_G 58 C>S No 1000Genomes
tmp_4_8870568_A_T 61 L>I No 1000Genomes
ENSVATH02844279 64 A>V No 1000Genomes
tmp_4_8870545_C_A 68 L>F No 1000Genomes
tmp_4_8870517_G_C 78 L>V No 1000Genomes
tmp_4_8870502_C_T 83 D>N No 1000Genomes
ENSVATH06678134 84 P>Q No 1000Genomes
tmp_4_8870492_G_C 86 A>G No 1000Genomes
tmp_4_8870487_T_C 88 I>V No 1000Genomes
tmp_4_8868960_G_A 127 S>L No 1000Genomes
ENSVATH02844259 144 I>V No 1000Genomes
tmp_4_8868904_C_T 146 G>S No 1000Genomes
ENSVATH11796451 151 E>D No 1000Genomes
ENSVATH00508291 166 R>S No 1000Genomes
tmp_4_8868287_T_C 229 D>G No 1000Genomes
tmp_4_8868173_T_C 236 M>V No 1000Genomes
tmp_4_8868144_C_A 245 E>D No 1000Genomes
tmp_4_8868142_T_C 246 K>R No 1000Genomes
ENSVATH14206036 249 R>K No 1000Genomes
tmp_4_8868116_C_G 255 G>R No 1000Genomes
ENSVATH06678074 256 V>F No 1000Genomes
tmp_4_8868085_G_A 265 A>V No 1000Genomes
tmp_4_8867905_C_T 299 E>K No 1000Genomes
tmp_4_8867883_T_C 306 D>G No 1000Genomes
tmp_4_8867785_C_T 339 D>N No 1000Genomes
ENSVATH00508281 387 F>L No 1000Genomes
tmp_4_8867521_A_G 401 I>T No 1000Genomes
tmp_4_8867356_G_A 428 A>V No 1000Genomes
ENSVATH00508278 450 E>D No 1000Genomes
tmp_4_8867290_T_C 450 E>G No 1000Genomes
ENSVATH00508272 479 E>A No 1000Genomes
ENSVATH02844206 563 E>D No 1000Genomes
ENSVATH06678031 609 P>Q No 1000Genomes
tmp_4_8866451_C_T 622 R>K No 1000Genomes
ENSVATH06678028 634 E>D No 1000Genomes
tmp_4_8866314_T_G 642 N>T No 1000Genomes
ENSVATH11796216 665 V>M No 1000Genomes
ENSVATH11796083 773 A>V No 1000Genomes
tmp_4_8865545_C_A 817 K>N No 1000Genomes
ENSVATH11796080 818 K>E No 1000Genomes
tmp_4_8865462_T_G 845 D>A No 1000Genomes
tmp_4_8865366_T_G 849 K>Q No 1000Genomes
tmp_4_8865291_C_T 874 G>S No 1000Genomes
tmp_4_8865252_G_T 887 Q>K No 1000Genomes
ENSVATH14205978 896 Q>* No 1000Genomes
ENSVATH06677997 901 Q>L No 1000Genomes
ENSVATH02844171 905 M>I No 1000Genomes
tmp_4_8865097_C_T 913 A>T No 1000Genomes
tmp_4_8865073_T_C 921 I>V No 1000Genomes
ENSVATH00508239 940 L>F No 1000Genomes
tmp_4_8864842_C_T 960 V>I No 1000Genomes

No associated diseases with O23404

7 regional properties for O23404

Type Name Position InterPro Accession
domain PEP-utilising enzyme, C-terminal 608 - 960 IPR000121
domain Pyruvate phosphate dikinase, AMP/ATP-binding 109 - 142 IPR002192-1
domain Pyruvate phosphate dikinase, AMP/ATP-binding 144 - 381 IPR002192-2
domain Pyruvate phosphate dikinase, AMP/ATP-binding 392 - 445 IPR002192-3
domain PEP-utilising enzyme, mobile domain 512 - 593 IPR008279
active_site PEP-utilising enzyme, active site 540 - 551 IPR018274
conserved_site PEP-utilising enzyme, conserved site 852 - 870 IPR023151

Functions

Description
EC Number 2.7.9.1 Phosphotransferases with paired acceptors
Subcellular Localization
  • Plastid, chloroplast
  • Cytoplasm
  • Isoform 1 is targeted to the chloroplast while isoform 2 is found in the cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
chloroplast stroma The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
kinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
metal ion binding Binding to a metal ion.
pyruvate, phosphate dikinase activity Catalysis of the reaction: ATP + phosphate + pyruvate = AMP + diphosphate + 2 H(+) + phosphoenolpyruvate.

3 GO annotations of biological process

Name Definition
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds.
pyruvate metabolic process The chemical reactions and pathways involving pyruvate, 2-oxopropanoate.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q42368 PPDK2 Pyruvate, phosphate dikinase 2 Zea mays (Maize) PR
P11155 PPDK1 Pyruvate, phosphate dikinase 1, chloroplastic Zea mays (Maize) PR
Q6AVA8 PPDK1 Pyruvate, phosphate dikinase 1, chloroplastic Oryza sativa subsp japonica (Rice) PR
10 20 30 40 50 60
MLYIRKKMTS MIVKTTPELF KGNGVFRTDH LGENRMVSRS NRLGDGSNRF PRTGTIHCQR
70 80 90 100 110 120
LSIAKTGLHR ETKARAILSP VSDPAASIAQ KRVFTFGKGR SEGNKGMKSL LGGKGANLAE
130 140 150 160 170 180
MASIGLSVPP GLTISTEACQ QYQIAGKKLP EGLWEEILEG LSFIERDIGA SLADPSKPLL
190 200 210 220 230 240
LSVRSGAAIS MPGMMDTVLN LGLNDQVVVG LAAKSGERFA YDSFRRFLDM FGDVVMGIPH
250 260 270 280 290 300
AKFEEKLERM KERKGVKNDT DLSAADLKEL VEQYKSVYLE AKGQEFPSDP KKQLELAIEA
310 320 330 340 350 360
VFDSWDSPRA NKYRSINQIT GLKGTAVNIQ CMVFGNMGDT SGTGVLFTRN PSTGEKKLYG
370 380 390 400 410 420
EFLVNAQGED VVAGIRTPED LDTMKRFMPE AYAELVENCN ILERHYKDMM DIEFTVQEER
430 440 450 460 470 480
LWMLQCRAGK RTGKGAVKIA VDMVGEGLVE KSSAIKMVEP QHLDQLLHPQ FHDPSGYREK
490 500 510 520 530 540
VVAKGLPASP GAAVGQVVFT AEEAEAWHSQ GKTVILVRTE TSPDDVGGMH AAEGILTARG
550 560 570 580 590 600
GMTSHAAVVA RGWGKCCIAG CSEIRVDENH KVLLIGDLTI NEGEWISMNG STGEVILGKQ
610 620 630 640 650 660
ALAPPALSPD LETFMSWADA IRRLKVMANA DTPEDAIAAR KNGAQGIGLC RTEHMFFGAD
670 680 690 700 710 720
RIKAVRKMIM AVTTEQRKAS LDILLPYQRS DFEGIFRAMD GLPVTIRLLD PPLHEFLPEG
730 740 750 760 770 780
DLDNIVHELA EETGVKEDEV LSRIEKLSEV NPMLGFRGCR LGISYPELTE MQARAIFEAA
790 800 810 820 830 840
ASMQDQGVTV IPEIMVPLVG TPQELGHQVD VIRKVAKKVF AEKGHTVSYK VGTMIEIPRA
850 860 870 880 890 900
ALIADEIAKE AEFFSFGTND LTQMTFGYSR DDVGKFLPIY LAKGILQHDP FEVLDQQGVG
910 920 930 940 950 960
QLIKMATEKG RAARPSLKVG ICGEHGGDPS SVGFFAEAGL DYVSCSPFRV PIARLAAAQV
VVA