O12971

PR
Gene name
LFNG
Protein name
Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
Names
O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:395790
EC number
2.4.1.222: Hexosyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

7-115 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O12971

Entry ID Method Resolution Chain Position Source
AF-O12971-F1 Predicted AlphaFoldDB

14 variants for O12971

Variant ID(s) Position Change Description Diseaes Association Provenance
rs734209754 137 D>G No Ensembl
rs732805732 156 H>P No Ensembl
rs735686525 191 V>G No Ensembl
rs736427040 195 V>G No Ensembl
rs739822405 199 S>P No Ensembl
rs735088832 201 Y>S No Ensembl
rs737125488 218 I>T No Ensembl
rs741493187 258 S>R No Ensembl
rs731275162 265 T>P No Ensembl
rs740953849 288 K>E No Ensembl
rs731086046 297 S>P No Ensembl
rs317168316 327 S>P No Ensembl
rs741474630 351 Y>S No Ensembl
rs730916642 361 V>G No Ensembl

No associated diseases with O12971

No regional properties for O12971

Type Name Position InterPro Accession
No domain, repeats, and functional sites for O12971

Functions

Description
EC Number 2.4.1.222 Hexosyltransferases
Subcellular Localization
  • Golgi apparatus membrane ; Single-pass type II membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
integral component of Golgi membrane The component of the Golgi membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

3 GO annotations of molecular function

Name Definition
acetylglucosaminyltransferase activity Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar.
metal ion binding Binding to a metal ion.
O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity Catalysis of the transfer of a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor.

11 GO annotations of biological process

Name Definition
compartment pattern specification The regionalization process in which embryonic segments are divided into compartments that will result in differences in cell differentiation.
marginal zone B cell differentiation The process in which a B cell in the spleen acquires the specialized features of a marginal zone B cell. Marginal zone B cells are localized in a distinct anatomical region of the spleen that represents the major antigen-filtering and scavenging area (by specialized macrophages resident there). It appears that they are preselected to express a BCR repertoire similar to B-1 B cells, biased toward bacterial cell wall constituents and senescent self-components (such as oxidized LDL).
negative regulation of Notch signaling pathway involved in somitogenesis Any process that stops, prevents or reduces the frequency, rate or extent of Notch signaling pathway involved in somitogenesis.
ovarian follicle development The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure.
positive regulation of meiotic cell cycle Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle.
positive regulation of Notch signaling pathway Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway.
positive regulation of protein binding Any process that activates or increases the frequency, rate or extent of protein binding.
regulation of Notch signaling pathway Any process that modulates the frequency, rate or extent of the Notch signaling pathway.
regulation of somitogenesis Any process that modulates the frequency, rate or extent of somitogenesis.
somitogenesis The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
T cell differentiation The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q24342 fng Fringe glycosyltransferase Drosophila melanogaster (Fruit fly) PR
10 20 30 40 50 60
MLKSCGRKLL LSLVGSMFTC LLVLMVEPPG RPGLARGEAG GAQRALQSLG AARAAGQGAP
70 80 90 100 110 120
GLRSFADYFG RLSRARRELP AAPPSPPRPP AEDITPRDVF IAVKTTKKFH KARLELLLDT
130 140 150 160 170 180
WISRNRDMTF IFTDGEDEEL KKQARNVINT NCSAAHSRQA LSCKMAVEYD KFIESGRKWF
190 200 210 220 230 240
CHVDDDNYVN VRTLVKLLSS YPHTQDIYIG KPSLDRPIQA TERISENKMH PVHFWFATGG
250 260 270 280 290 300
AGFCISRGLA LKMSPWASGG HFMSTAEKIR LPDDCTIGYI IESVLGVKLI RSNLFHSHLE
310 320 330 340 350 360
NLHQVPKTEI HKQVTLSYGM FENKRNSIHM KGAFSVEEDP SRFRSVHCLL YPDTPWCPSN
VVY