O08721
Gene name |
Unc5a (Unc5h1) |
Protein name |
Netrin receptor UNC5A |
Names |
Protein unc-5 homolog 1 , Protein unc-5 homolog A |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
rno:60629 |
EC number |
|
Protein Class |
|
Descriptions
Autoinhibitory domains (AIDs)
Target domain |
495-895 (ZU5-UPA-DD) |
Relief mechanism |
Ligand binding |
Assay |
|
Target domain |
495-895 (ZU5-UPA-DD) |
Relief mechanism |
Ligand binding |
Assay |
|
Target domain |
495-895 (ZU5-UPA-DD) |
Relief mechanism |
Ligand binding |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O08721
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O08721-F1 | Predicted | AlphaFoldDB |
No variants for O08721
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O08721 | |||||
No associated diseases with O08721
10 regional properties for O08721
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Oxidoreductase FAD/NAD(P)-binding | 213 - 327 | IPR001433 |
| domain | Flavoprotein pyridine nucleotide cytochrome reductase | 116 - 126 | IPR001709-1 |
| domain | Flavoprotein pyridine nucleotide cytochrome reductase | 139 - 146 | IPR001709-2 |
| domain | Flavoprotein pyridine nucleotide cytochrome reductase | 176 - 185 | IPR001709-3 |
| domain | Flavoprotein pyridine nucleotide cytochrome reductase | 212 - 231 | IPR001709-4 |
| domain | Flavoprotein pyridine nucleotide cytochrome reductase | 242 - 251 | IPR001709-5 |
| domain | Flavoprotein pyridine nucleotide cytochrome reductase | 254 - 265 | IPR001709-6 |
| domain | Flavoprotein pyridine nucleotide cytochrome reductase | 290 - 306 | IPR001709-7 |
| domain | Flavoprotein pyridine nucleotide cytochrome reductase | 314 - 322 | IPR001709-8 |
| domain | FAD-binding domain, ferredoxin reductase-type | 81 - 203 | IPR017927 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| membrane raft | Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions. |
| neuron projection membrane | The portion of the plasma membrane surrounding a neuron projection. |
| neuronal cell body membrane | The plasma membrane of a neuron cell body - excludes the plasma membrane of cell projections such as axons and dendrites. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| netrin receptor activity | Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| anterior/posterior axon guidance | The process in which the migration of an axon growth cone is directed to a specific target site along the anterior-posterior body axis in response to a combination of attractive and repulsive cues. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism. |
| apoptotic process | A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. |
| axon guidance | The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. |
| netrin-activated signaling pathway | The series of molecular signals initiated by the binding of a netrin protein to its receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Netrins can act as chemoattractant signals for some cells and chemorepellent signals for others. Netrins also have roles outside of cell and axon guidance. |
| neuron projection development | The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q7T2Z5 | UNC5C | Netrin receptor UNC5C | Gallus gallus (Chicken) | SS |
| Q8IZJ1 | UNC5B | Netrin receptor UNC5B | Homo sapiens (Human) | SS |
| Q6UXZ4 | UNC5D | Netrin receptor UNC5D | Homo sapiens (Human) | SS |
| O95185 | UNC5C | Netrin receptor UNC5C | Homo sapiens (Human) | SS |
| Q6ZN44 | UNC5A | Netrin receptor UNC5A | Homo sapiens (Human) | SS |
| Q8K1S3 | Unc5b | Netrin receptor UNC5B | Mus musculus (Mouse) | SS |
| O08747 | Unc5c | Netrin receptor UNC5C | Mus musculus (Mouse) | SS |
| Q8K1S2 | Unc5d | Netrin receptor UNC5D | Mus musculus (Mouse) | SS |
| Q8K1S4 | Unc5a | Netrin receptor UNC5A | Mus musculus (Mouse) | SS |
| O08722 | Unc5b | Netrin receptor UNC5B | Rattus norvegicus (Rat) | EV |
| F1LW30 | Unc5d | Netrin receptor UNC5D | Rattus norvegicus (Rat) | SS |
| Q761X5 | Unc5c | Netrin receptor UNC5C | Rattus norvegicus (Rat) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEPPGPSTPT | ASAAARADHY | TPGLRPLPKR | RLLYSFALLL | AVLQAVFVPV | TANPAHNRPA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GLQRPEESPS | RGPCLAGQYL | SEGNCKPCRE | GIDYTSHSNH | SLDSCILCTV | CKEDKVVETR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| CNITTNTVCR | CKPGTFEDKD | SPEICQSCSN | CTDGEEELTS | CTPRENRKCV | SKTAWASWHK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LGLWIGLLVP | VVLLIGALLV | WKTGAWRQWL | LCIKRGCERD | PESANSVHSS | LLDRQTSSTT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NDSNHNTEPG | KTQKTGKKLL | VPVNGNDSAD | DLKFIFEYCS | DIVPFDSWNR | LMRQLGLTDN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QIQMVKAETL | VTREALYQML | LKWRHQTGRS | ASINHLLDAL | EAVEERDAME | KIEDYAVKSG |
| 370 | 380 | ||||
| RFTYQNAAAQ | PETGPGGSQC | V |