G5EG14

PR
Gene name
cacn-1 (W03H9.4)
Protein name
Cactin
Names
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_W03H9.4
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-107 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for G5EG14

Entry ID Method Resolution Chain Position Source
AF-G5EG14-F1 Predicted AlphaFoldDB

No variants for G5EG14

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for G5EG14

No associated diseases with G5EG14

5 regional properties for G5EG14

Type Name Position InterPro Accession
domain TolB, N-terminal 24 - 126 IPR007195
repeat WD40-like beta propeller 206 - 235 IPR011659-1
repeat WD40-like beta propeller 247 - 282 IPR011659-2
repeat WD40-like beta propeller 291 - 326 IPR011659-3
repeat WD40-like beta propeller 336 - 368 IPR011659-4

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
spliceosomal complex Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA.

1 GO annotations of molecular function

Name Definition
RNA binding Binding to an RNA molecule or a portion thereof.

6 GO annotations of biological process

Name Definition
gonad development The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones.
mRNA cis splicing, via spliceosome The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript.
positive regulation of cell migration Any process that activates or increases the frequency, rate or extent of cell migration.
regulation of cell migration Any process that modulates the frequency, rate or extent of cell migration.
regulation of gene expression Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
regulation of Wnt signaling pathway Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8WUQ7 CACTIN Cactin Homo sapiens (Human) PR
Q9CS00 Cactin Cactin Mus musculus (Mouse) PR
10 20 30 40 50 60
MGKDSKKHKK ERRRERSPST SDSDEERLQK RLAEQRSLKK DEKRRQKEEM KKNESAEEKR
70 80 90 100 110 120
ARRMEKKMRK DAKRKDADAE DTLIPPELNY TNLNNPFNDT KLTQTFVWGK KLEREGKSGL
130 140 150 160 170 180
TQDEITKQTS QRIRKNLHEA AEFKRIRDSR AAAKEDMEMM KRDADLRAGQ ISDTKEREFQ
190 200 210 220 230 240
MDQIKERTRI RIDQGRAKAI DLLSRYARFA DENPHTAKIP DFELENPMEY LKASCKSVDD
250 260 270 280 290 300
YEDLIEDIKT YREVDGWAKN ETWWMDVTRI AEDEIQKKAA QNRGDVHASV QTEVQNMFKN
310 320 330 340 350 360
KSIDELLKLE DQMDAKIRGN SGNKGYWQDL DDQLKVFIAR KRLREHHGRV LRLQLAIIKE
370 380 390 400 410 420
EQKKEIQQQE SEELLPVAEV PPQVKIQKEE EEEEEEDEDD EKISKKVRRK IDVQTLDDPE
430 440 450 460 470 480
LDEPERERKW RALTGDQLDD VTRELYRIGC YSPTYISADD TMPGIEILDE QADVDNLTER
490 500 510 520 530 540
RNRNRGTLPS SSAASSGAPQ GASSKMMAIA REGMEADESI FGAEEQLAAQ RHLWSDKYRP
550 560 570 580 590 600
RKPTYLNRVQ TGFDWNKYNQ THYDQDNPPP KIVQGYKFNI FYPDLLDMTV APRFGLTSCE
610 620 630 640 650
DPDFAIIRFK AGPPYEDIAF KVVNREWETL HKNGYKCQFQ NGVFQLWFMF KKYRYRR